Chlorine in PDB 5lb6: Hif Prolyl Hydroxylase 2 (PHD2/EGLN1) R371H Variant in Complex with Mn(II) and N-[(1-Chloro-4-Hydroxyisoquinolin-3-Yl)Carbonyl]Glycine (IOX3/UN9)

Enzymatic activity of Hif Prolyl Hydroxylase 2 (PHD2/EGLN1) R371H Variant in Complex with Mn(II) and N-[(1-Chloro-4-Hydroxyisoquinolin-3-Yl)Carbonyl]Glycine (IOX3/UN9)

All present enzymatic activity of Hif Prolyl Hydroxylase 2 (PHD2/EGLN1) R371H Variant in Complex with Mn(II) and N-[(1-Chloro-4-Hydroxyisoquinolin-3-Yl)Carbonyl]Glycine (IOX3/UN9):
1.14.11.29;

Protein crystallography data

The structure of Hif Prolyl Hydroxylase 2 (PHD2/EGLN1) R371H Variant in Complex with Mn(II) and N-[(1-Chloro-4-Hydroxyisoquinolin-3-Yl)Carbonyl]Glycine (IOX3/UN9), PDB code: 5lb6 was solved by R.Chowdhury, C.J.Schofield, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	36.39 / 1.70
*Space group*	P 6₃
*Cell size a, b, c (Å), α, β, γ (°)*	111.159, 111.159, 40.380, 90.00, 90.00, 120.00
*R / R_free (%)*	14.5 / 16.8

Other elements in 5lb6:

Manganese

(Mn)

1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Hif Prolyl Hydroxylase 2 (PHD2/EGLN1) R371H Variant in Complex with Mn(II) and N-[(1-Chloro-4-Hydroxyisoquinolin-3-Yl)Carbonyl]Glycine (IOX3/UN9) (pdb code 5lb6). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Hif Prolyl Hydroxylase 2 (PHD2/EGLN1) R371H Variant in Complex with Mn(II) and N-[(1-Chloro-4-Hydroxyisoquinolin-3-Yl)Carbonyl]Glycine (IOX3/UN9), PDB code: 5lb6:

Chlorine binding site 1 out of 1 in 5lb6

Go back to

Chlorine Binding Sites List in 5lb6

Chlorine binding site 1 out of 1 in the Hif Prolyl Hydroxylase 2 (PHD2/EGLN1) R371H Variant in Complex with Mn(II) and N-[(1-Chloro-4-Hydroxyisoquinolin-3-Yl)Carbonyl]Glycine (IOX3/UN9)

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Hif Prolyl Hydroxylase 2 (PHD2/EGLN1) R371H Variant in Complex with Mn(II) and N-[(1-Chloro-4-Hydroxyisoquinolin-3-Yl)Carbonyl]Glycine (IOX3/UN9) within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Cl502 b:17.1 occ:1.00	CL1	A:UN9502	0.0	17.1	1.0
	C7	A:UN9502	1.8	13.7	1.0
	N8	A:UN9502	2.6	14.8	1.0
	H1	A:UN9502	2.6	21.9	1.0
	C2	A:UN9502	2.8	17.0	1.0
	C1	A:UN9502	3.1	18.2	1.0
	O	A:HOH706	3.2	39.9	1.0
	OD1	A:ASP315	3.4	14.2	1.0
	MN	A:MN501	3.5	13.1	1.0
	HZ2	A:TRP389	3.5	16.5	1.0
	HD2	A:HIS313	3.5	17.9	1.0
	NE2	A:HIS313	3.6	12.4	1.0
	CD2	A:HIS313	3.7	14.9	1.0
	HA	A:ASP315	3.9	18.1	1.0
	C9	A:UN9502	3.9	13.4	1.0
	C3	A:UN9502	4.0	14.6	1.0
	OH	A:TYR310	4.1	20.3	1.0
	O	A:HOH655	4.1	28.4	1.0
	O	A:HOH710	4.2	39.3	1.0
	CG	A:ASP315	4.2	15.3	1.0
	CZ2	A:TRP389	4.3	13.8	1.0
	O	A:HOH623	4.3	14.5	1.0
	HH	A:TYR310	4.3	24.3	1.0
	HH2	A:TRP389	4.4	20.3	1.0
	C10	A:UN9502	4.5	13.8	1.0
	CZ	A:TYR310	4.5	17.5	1.0
	C6	A:UN9502	4.5	15.2	1.0
	HE1	A:TYR310	4.6	20.5	1.0
	CE1	A:HIS313	4.6	14.4	1.0
	CE1	A:TYR310	4.7	17.1	1.0
	HH12	A:ARG322	4.7	30.1	1.0
	CH2	A:TRP389	4.7	16.9	1.0
	CA	A:ASP315	4.8	15.0	1.0
	HE1	A:MET299	4.8	18.0	1.0
	CG	A:HIS313	4.9	15.3	1.0
	OD2	A:ASP315	4.9	14.4	1.0
	C12	A:UN9502	4.9	12.2	1.0
	O13	A:UN9502	4.9	14.2	1.0
	CB	A:ASP315	4.9	15.6	1.0
	H6	A:UN9502	5.0	18.3	1.0
	HB3	A:ASP315	5.0	18.7	1.0

Reference:

R.Chowdhury, I.K.Leung, Y.M.Tian, M.I.Abboud, W.Ge, C.Domene, F.X.Cantrelle, I.Landrieu, A.P.Hardy, C.W.Pugh, P.J.Ratcliffe, T.D.Claridge, C.J.Schofield. Structural Basis For Oxygen Degradation Domain Selectivity of the Hif Prolyl Hydroxylases. Nat Commun V. 7 12673 2016.
ISSN: ESSN 2041-1723
PubMed: 27561929
DOI: 10.1038/NCOMMS12673

Page generated: Fri Jul 26 11:17:58 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0

	© Copyright 2008-2020 by atomistry.com
Home \| Site Map \| Copyright \| Contact us \| Privacy