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Chlorine in PDB 5lp1: Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution.
Enzymatic activity of Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution.
All present enzymatic activity of Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution.:
3.1.1.47;
3.1.1.47;
Protein crystallography data
The structure of Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution., PDB code: 5lp1
was solved by
D.Somers,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 20.00 / 1.91 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 100.280, 91.560, 51.650, 90.00, 111.88, 90.00 |
| R / Rfree (%) | 16.2 / 19.2 |
Other elements in 5lp1:
The structure of Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution. also contains other interesting chemical elements:
| Fluorine | (F) | 4 atoms |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution.
(pdb code 5lp1). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution., PDB code: 5lp1:
Jump to Chlorine binding site number: 1; 2;
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution., PDB code: 5lp1:
Jump to Chlorine binding site number: 1; 2;
Chlorine binding site 1 out of 2 in 5lp1
Go back to
Chlorine Binding Sites List in 5lp1
Chlorine binding site 1 out
of 2 in the Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution. within 5.0Å range:
|
Chlorine binding site 2 out of 2 in 5lp1
Go back to
Chlorine Binding Sites List in 5lp1
Chlorine binding site 2 out
of 2 in the Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution. within 5.0Å range:
|
Reference:
N.D.Measom,
K.D.Down,
D.J.Hirst,
C.Jamieson,
E.S.Manas,
V.K.Patel,
D.O.Somers.
Investigation of A Bicyclo[1.1.1]Pentane As A Phenyl Replacement Within An LPPLA2 Inhibitor. Acs Med Chem Lett V. 8 43 2017.
ISSN: ISSN 1948-5875
PubMed: 28105273
DOI: 10.1021/ACSMEDCHEMLETT.6B00281
Page generated: Fri Jul 26 12:04:32 2024
ISSN: ISSN 1948-5875
PubMed: 28105273
DOI: 10.1021/ACSMEDCHEMLETT.6B00281
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