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Chlorine in PDB 5lvo: Human PDK1 Kinase Domain in Complex with Allosteric Compound PSE10 Bound to the Pif-Pocket
Enzymatic activity of Human PDK1 Kinase Domain in Complex with Allosteric Compound PSE10 Bound to the Pif-Pocket
All present enzymatic activity of Human PDK1 Kinase Domain in Complex with Allosteric Compound PSE10 Bound to the Pif-Pocket:
2.7.11.1;
2.7.11.1;
Protein crystallography data
The structure of Human PDK1 Kinase Domain in Complex with Allosteric Compound PSE10 Bound to the Pif-Pocket, PDB code: 5lvo
was solved by
J.O.Schulze,
G.Saladino,
K.Busschots,
S.Neimanis,
E.Suess,
D.Odadzic,
S.Zeuzem,
V.Hindie,
A.K.Herbrand,
M.N.Lisa,
P.M.Alzari,
F.L.Gervasio,
R.M.Biondi,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 72.54 / 1.09 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 148.220, 44.420, 47.870, 90.00, 101.81, 90.00 |
| R / Rfree (%) | 13.5 / 15.7 |
Other elements in 5lvo:
The structure of Human PDK1 Kinase Domain in Complex with Allosteric Compound PSE10 Bound to the Pif-Pocket also contains other interesting chemical elements:
| Fluorine | (F) | 1 atom |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Human PDK1 Kinase Domain in Complex with Allosteric Compound PSE10 Bound to the Pif-Pocket
(pdb code 5lvo). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Human PDK1 Kinase Domain in Complex with Allosteric Compound PSE10 Bound to the Pif-Pocket, PDB code: 5lvo:
Jump to Chlorine binding site number: 1; 2; 3;
In total 3 binding sites of Chlorine where determined in the Human PDK1 Kinase Domain in Complex with Allosteric Compound PSE10 Bound to the Pif-Pocket, PDB code: 5lvo:
Jump to Chlorine binding site number: 1; 2; 3;
Chlorine binding site 1 out of 3 in 5lvo
Go back to
Chlorine Binding Sites List in 5lvo
Chlorine binding site 1 out
of 3 in the Human PDK1 Kinase Domain in Complex with Allosteric Compound PSE10 Bound to the Pif-Pocket
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Human PDK1 Kinase Domain in Complex with Allosteric Compound PSE10 Bound to the Pif-Pocket within 5.0Å range:
|
Chlorine binding site 2 out of 3 in 5lvo
Go back to
Chlorine Binding Sites List in 5lvo
Chlorine binding site 2 out
of 3 in the Human PDK1 Kinase Domain in Complex with Allosteric Compound PSE10 Bound to the Pif-Pocket
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Human PDK1 Kinase Domain in Complex with Allosteric Compound PSE10 Bound to the Pif-Pocket within 5.0Å range:
|
Chlorine binding site 3 out of 3 in 5lvo
Go back to
Chlorine Binding Sites List in 5lvo
Chlorine binding site 3 out
of 3 in the Human PDK1 Kinase Domain in Complex with Allosteric Compound PSE10 Bound to the Pif-Pocket
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 3 of Human PDK1 Kinase Domain in Complex with Allosteric Compound PSE10 Bound to the Pif-Pocket within 5.0Å range:
|
Reference:
J.O.Schulze,
G.Saladino,
K.Busschots,
S.Neimanis,
E.Su,
D.Odadzic,
S.Zeuzem,
V.Hindie,
A.K.Herbrand,
M.N.Lisa,
P.M.Alzari,
F.L.Gervasio,
R.M.Biondi.
Bidirectional Allosteric Communication Between the Atp-Binding Site and the Regulatory Pif Pocket in PDK1 Protein Kinase. Cell Chem Biol V. 23 1193 2016.
ISSN: ESSN 2451-9456
PubMed: 27693059
DOI: 10.1016/J.CHEMBIOL.2016.06.017
Page generated: Fri Jul 26 12:16:16 2024
ISSN: ESSN 2451-9456
PubMed: 27693059
DOI: 10.1016/J.CHEMBIOL.2016.06.017
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