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Atomistry » Chlorine » PDB 5luh-5lz8 » 5lxc | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 5luh-5lz8 » 5lxc » |
Chlorine in PDB 5lxc: Crystal Structure of DYRK2 in Complex with Eht 5372 (Compound 1)Enzymatic activity of Crystal Structure of DYRK2 in Complex with Eht 5372 (Compound 1)
All present enzymatic activity of Crystal Structure of DYRK2 in Complex with Eht 5372 (Compound 1):
2.7.12.1; Protein crystallography data
The structure of Crystal Structure of DYRK2 in Complex with Eht 5372 (Compound 1), PDB code: 5lxc
was solved by
A.Chaikuad,
F.Von Delft,
C.H.Arrowsmith,
A.Edwards,
C.Bountra,
T.Besson,
S.Knapp,
Structural Genomics Consortium (Sgc),
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of DYRK2 in Complex with Eht 5372 (Compound 1)
(pdb code 5lxc). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Crystal Structure of DYRK2 in Complex with Eht 5372 (Compound 1), PDB code: 5lxc: Jump to Chlorine binding site number: 1; 2; 3; 4; Chlorine binding site 1 out of 4 in 5lxcGo back to Chlorine Binding Sites List in 5lxc
Chlorine binding site 1 out
of 4 in the Crystal Structure of DYRK2 in Complex with Eht 5372 (Compound 1)
Mono view Stereo pair view
Chlorine binding site 2 out of 4 in 5lxcGo back to Chlorine Binding Sites List in 5lxc
Chlorine binding site 2 out
of 4 in the Crystal Structure of DYRK2 in Complex with Eht 5372 (Compound 1)
Mono view Stereo pair view
Chlorine binding site 3 out of 4 in 5lxcGo back to Chlorine Binding Sites List in 5lxc
Chlorine binding site 3 out
of 4 in the Crystal Structure of DYRK2 in Complex with Eht 5372 (Compound 1)
Mono view Stereo pair view
Chlorine binding site 4 out of 4 in 5lxcGo back to Chlorine Binding Sites List in 5lxc
Chlorine binding site 4 out
of 4 in the Crystal Structure of DYRK2 in Complex with Eht 5372 (Compound 1)
Mono view Stereo pair view
Reference:
A.Chaikuad,
J.Diharce,
M.Schroder,
A.Foucourt,
B.Leblond,
A.S.Casagrande,
L.Desire,
P.Bonnet,
S.Knapp,
T.Besson.
An Unusual Binding Model of the Methyl 9-Anilinothiazolo[5,4-F] Quinazoline-2-Carbimidates (Eht 1610 and Eht 5372) Confers High Selectivity For Dual-Specificity Tyrosine Phosphorylation-Regulated Kinases. J. Med. Chem. V. 59 10315 2016.
Page generated: Sat Dec 12 12:04:35 2020
ISSN: ISSN 1520-4804 PubMed: 27766861 DOI: 10.1021/ACS.JMEDCHEM.6B01083 |
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