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Chlorine in PDB 5lz9: Fragment-Based Inhibitors of Lipoprotein Associated Phospholipase A2
Enzymatic activity of Fragment-Based Inhibitors of Lipoprotein Associated Phospholipase A2
All present enzymatic activity of Fragment-Based Inhibitors of Lipoprotein Associated Phospholipase A2:
3.1.1.47;
3.1.1.47;
Protein crystallography data
The structure of Fragment-Based Inhibitors of Lipoprotein Associated Phospholipase A2, PDB code: 5lz9
was solved by
A.Woolford,
P.Day,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 44.39 / 2.06 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 100.044, 91.332, 51.357, 90.00, 111.97, 90.00 |
| R / Rfree (%) | 18.3 / 23.3 |
Other elements in 5lz9:
The structure of Fragment-Based Inhibitors of Lipoprotein Associated Phospholipase A2 also contains other interesting chemical elements:
| Fluorine | (F) | 1 atom |
| Sodium | (Na) | 1 atom |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Fragment-Based Inhibitors of Lipoprotein Associated Phospholipase A2
(pdb code 5lz9). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Fragment-Based Inhibitors of Lipoprotein Associated Phospholipase A2, PDB code: 5lz9:
In total only one binding site of Chlorine was determined in the Fragment-Based Inhibitors of Lipoprotein Associated Phospholipase A2, PDB code: 5lz9:
Chlorine binding site 1 out of 1 in 5lz9
Go back to
Chlorine Binding Sites List in 5lz9
Chlorine binding site 1 out
of 1 in the Fragment-Based Inhibitors of Lipoprotein Associated Phospholipase A2
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Fragment-Based Inhibitors of Lipoprotein Associated Phospholipase A2 within 5.0Å range:
|
Reference:
A.J.Woolford,
P.J.Day,
V.Beneton,
V.Berdini,
J.E.Coyle,
Y.Dudit,
P.Grondin,
P.Huet,
L.Y.Lee,
E.S.Manas,
R.L.Mcmenamin,
C.W.Murray,
L.W.Page,
V.K.Patel,
F.Potvain,
S.J.Rich,
Y.Sang,
D.O.Somers,
L.Trottet,
Z.Wan,
X.Zhang.
Fragment-Based Approach to the Development of An Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2). J. Med. Chem. V. 59 10738 2016.
ISSN: ISSN 1520-4804
PubMed: 27933945
DOI: 10.1021/ACS.JMEDCHEM.6B01427
Page generated: Fri Jul 26 12:21:17 2024
ISSN: ISSN 1520-4804
PubMed: 27933945
DOI: 10.1021/ACS.JMEDCHEM.6B01427
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