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Chlorine in PDB 5m44: Complex Structure of Human Protein Kinase CK2 Catalytic Subunit with A Thieno[2,3-D]Pyrimidin Inhibitor Crystallized Under High-Salt Conditions
Enzymatic activity of Complex Structure of Human Protein Kinase CK2 Catalytic Subunit with A Thieno[2,3-D]Pyrimidin Inhibitor Crystallized Under High-Salt Conditions
All present enzymatic activity of Complex Structure of Human Protein Kinase CK2 Catalytic Subunit with A Thieno[2,3-D]Pyrimidin Inhibitor Crystallized Under High-Salt Conditions:
2.7.11.1;
2.7.11.1;
Protein crystallography data
The structure of Complex Structure of Human Protein Kinase CK2 Catalytic Subunit with A Thieno[2,3-D]Pyrimidin Inhibitor Crystallized Under High-Salt Conditions, PDB code: 5m44
was solved by
K.Niefind,
N.Bischoff,
S.M.Yarmoluk,
V.G.Bdzhola,
A.G.Golub,
A.O.Balanda,
A.O.Prykhod'ko,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 27.84 / 2.71 |
| Space group | P 43 21 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 72.061, 72.061, 131.579, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 21.9 / 25.9 |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Complex Structure of Human Protein Kinase CK2 Catalytic Subunit with A Thieno[2,3-D]Pyrimidin Inhibitor Crystallized Under High-Salt Conditions
(pdb code 5m44). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 5 binding sites of Chlorine where determined in the Complex Structure of Human Protein Kinase CK2 Catalytic Subunit with A Thieno[2,3-D]Pyrimidin Inhibitor Crystallized Under High-Salt Conditions, PDB code: 5m44:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5;
In total 5 binding sites of Chlorine where determined in the Complex Structure of Human Protein Kinase CK2 Catalytic Subunit with A Thieno[2,3-D]Pyrimidin Inhibitor Crystallized Under High-Salt Conditions, PDB code: 5m44:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5;
Chlorine binding site 1 out of 5 in 5m44
Go back to
Chlorine Binding Sites List in 5m44
Chlorine binding site 1 out
of 5 in the Complex Structure of Human Protein Kinase CK2 Catalytic Subunit with A Thieno[2,3-D]Pyrimidin Inhibitor Crystallized Under High-Salt Conditions
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Complex Structure of Human Protein Kinase CK2 Catalytic Subunit with A Thieno[2,3-D]Pyrimidin Inhibitor Crystallized Under High-Salt Conditions within 5.0Å range:
|
Chlorine binding site 2 out of 5 in 5m44
Go back to
Chlorine Binding Sites List in 5m44
Chlorine binding site 2 out
of 5 in the Complex Structure of Human Protein Kinase CK2 Catalytic Subunit with A Thieno[2,3-D]Pyrimidin Inhibitor Crystallized Under High-Salt Conditions
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Complex Structure of Human Protein Kinase CK2 Catalytic Subunit with A Thieno[2,3-D]Pyrimidin Inhibitor Crystallized Under High-Salt Conditions within 5.0Å range:
|
Chlorine binding site 3 out of 5 in 5m44
Go back to
Chlorine Binding Sites List in 5m44
Chlorine binding site 3 out
of 5 in the Complex Structure of Human Protein Kinase CK2 Catalytic Subunit with A Thieno[2,3-D]Pyrimidin Inhibitor Crystallized Under High-Salt Conditions
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 3 of Complex Structure of Human Protein Kinase CK2 Catalytic Subunit with A Thieno[2,3-D]Pyrimidin Inhibitor Crystallized Under High-Salt Conditions within 5.0Å range:
|
Chlorine binding site 4 out of 5 in 5m44
Go back to
Chlorine Binding Sites List in 5m44
Chlorine binding site 4 out
of 5 in the Complex Structure of Human Protein Kinase CK2 Catalytic Subunit with A Thieno[2,3-D]Pyrimidin Inhibitor Crystallized Under High-Salt Conditions
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 4 of Complex Structure of Human Protein Kinase CK2 Catalytic Subunit with A Thieno[2,3-D]Pyrimidin Inhibitor Crystallized Under High-Salt Conditions within 5.0Å range:
|
Chlorine binding site 5 out of 5 in 5m44
Go back to
Chlorine Binding Sites List in 5m44
Chlorine binding site 5 out
of 5 in the Complex Structure of Human Protein Kinase CK2 Catalytic Subunit with A Thieno[2,3-D]Pyrimidin Inhibitor Crystallized Under High-Salt Conditions
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 5 of Complex Structure of Human Protein Kinase CK2 Catalytic Subunit with A Thieno[2,3-D]Pyrimidin Inhibitor Crystallized Under High-Salt Conditions within 5.0Å range:
|
Reference:
K.Niefind,
N.Bischoff,
A.G.Golub,
V.G.Bdzhola,
A.O.Balanda,
A.O.Prykhod'ko,
S.M.Yarmoluk.
Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed By Complex Structures with A Flavonol- and A Thieno[2,3-D]Pyrimidine-Based Inhibitor. Pharmaceuticals V. 10 2017.
ISSN: ESSN 1424-8247
PubMed: 28085026
DOI: 10.3390/PH10010009
Page generated: Fri Jul 26 12:25:49 2024
ISSN: ESSN 1424-8247
PubMed: 28085026
DOI: 10.3390/PH10010009
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