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Atomistry » Chlorine » PDB 5mgd-5mli » 5ml0 » |
Chlorine in PDB 5ml0: Bromodomain of Mouse Pcaf with (R)-4-Chloro-2-Methyl-5-((1- Methylpiperidin-3-Yl)Amino)Pyridazin-3(2H)-OneEnzymatic activity of Bromodomain of Mouse Pcaf with (R)-4-Chloro-2-Methyl-5-((1- Methylpiperidin-3-Yl)Amino)Pyridazin-3(2H)-One
All present enzymatic activity of Bromodomain of Mouse Pcaf with (R)-4-Chloro-2-Methyl-5-((1- Methylpiperidin-3-Yl)Amino)Pyridazin-3(2H)-One:
2.3.1.48; Protein crystallography data
The structure of Bromodomain of Mouse Pcaf with (R)-4-Chloro-2-Methyl-5-((1- Methylpiperidin-3-Yl)Amino)Pyridazin-3(2H)-One, PDB code: 5ml0
was solved by
C.-W.Chung,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Bromodomain of Mouse Pcaf with (R)-4-Chloro-2-Methyl-5-((1- Methylpiperidin-3-Yl)Amino)Pyridazin-3(2H)-One
(pdb code 5ml0). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Bromodomain of Mouse Pcaf with (R)-4-Chloro-2-Methyl-5-((1- Methylpiperidin-3-Yl)Amino)Pyridazin-3(2H)-One, PDB code: 5ml0: Chlorine binding site 1 out of 1 in 5ml0Go back to Chlorine Binding Sites List in 5ml0
Chlorine binding site 1 out
of 1 in the Bromodomain of Mouse Pcaf with (R)-4-Chloro-2-Methyl-5-((1- Methylpiperidin-3-Yl)Amino)Pyridazin-3(2H)-One
Mono view Stereo pair view
Reference:
P.G.Humphreys,
P.Bamborough,
C.W.Chung,
P.D.Craggs,
L.Gordon,
P.Grandi,
T.G.Hayhow,
J.Hussain,
K.L.Jones,
M.Lindon,
A.M.Michon,
J.F.Renaux,
C.J.Suckling,
D.F.Tough,
R.K.Prinjha.
Discovery of A Potent, Cell Penetrant, and Selective P300/Cbp-Associated Factor (Pcaf)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe. J. Med. Chem. V. 60 695 2017.
Page generated: Sat Dec 12 12:06:36 2020
ISSN: ISSN 1520-4804 PubMed: 28002667 DOI: 10.1021/ACS.JMEDCHEM.6B01566 |
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