Chlorine in PDB 5mzf: Crystal Structure of Dog MTH1 Protein

The structure of Crystal Structure of Dog MTH1 Protein, PDB code: 5mzf was solved by M.Narwal, A.-S.Jemth, T.Helleday, P.Stenmark, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.40 / 2.00
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	56.459, 67.353, 93.256, 90.00, 90.28, 90.00
R / Rfree (%)	19 / 23.4

The binding sites of Chlorine atom in the Crystal Structure of Dog MTH1 Protein (pdb code 5mzf). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Dog MTH1 Protein, PDB code: 5mzf:

Chlorine binding site 1 out of 1 in the Crystal Structure of Dog MTH1 Protein


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Dog MTH1 Protein within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl204 b:15.0 occ:1.00 O B:HOH371 2.7 35.4 1.0 N B:GLY76 3.1 11.5 1.0 N B:GLY141 3.2 14.5 1.0 CA B:GLY76 3.5 12.1 1.0 CB B:PHE74 3.7 10.2 1.0 N B:VAL75 3.8 11.5 1.0 CA B:GLY141 3.8 15.4 1.0 C B:PHE74 4.0 10.7 1.0 CD2 B:PHE74 4.0 10.2 1.0 CA B:PHE74 4.1 10.3 1.0 C B:GLY76 4.2 12.7 1.0 O B:PHE139 4.2 10.1 1.0 C B:GLN140 4.2 14.0 1.0 C B:VAL75 4.2 11.9 1.0 CA B:GLN140 4.3 13.2 0.4 CA B:GLN140 4.3 13.8 0.6 CG B:PHE74 4.3 10.2 1.0 N B:GLU77 4.4 13.3 1.0 CA B:VAL75 4.5 11.8 1.0 CG B:GLU77 4.5 16.0 1.0 O B:PHE74 4.6 10.9 1.0 C B:GLY141 4.7 16.2 1.0 C B:PHE139 4.8 11.3 1.0 O B:GLY141 4.8 17.1 1.0 CB B:VAL75 4.9 12.8 1.0 NE2 B:GLN140 4.9 13.8 0.4 N B:GLN140 4.9 13.0 1.0 O B:GLY76 4.9 13.3 1.0

M.Narwal, A.S.Jemth, R.Gustafsson, I.Almlof, U.Warpman Berglund, T.Helleday, P.Stenmark. Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity. Biochemistry V. 57 593 2018.
ISSN: ISSN 1520-4995
PubMed: 29281266
DOI: 10.1021/ACS.BIOCHEM.7B01163