Atomistry » Chlorine » PDB 5mzc-5n6s » 5n26
Atomistry »
  Chlorine »
    PDB 5mzc-5n6s »
      5n26 »

Chlorine in PDB 5n26: X-Ray Structure of Human Heavy Chain Ferritin in Complex with Cisplatin

Enzymatic activity of X-Ray Structure of Human Heavy Chain Ferritin in Complex with Cisplatin

All present enzymatic activity of X-Ray Structure of Human Heavy Chain Ferritin in Complex with Cisplatin:
1.16.3.1;

Protein crystallography data

The structure of X-Ray Structure of Human Heavy Chain Ferritin in Complex with Cisplatin, PDB code: 5n26 was solved by G.Ferraro, A.Merlino, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 105.69 / 2.05
Space group F 4 3 2
Cell size a, b, c (Å), α, β, γ (°) 183.069, 183.069, 183.069, 90.00, 90.00, 90.00
R / Rfree (%) 16.3 / 20.6

Other elements in 5n26:

The structure of X-Ray Structure of Human Heavy Chain Ferritin in Complex with Cisplatin also contains other interesting chemical elements:

Magnesium (Mg) 5 atoms
Platinum (Pt) 7 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the X-Ray Structure of Human Heavy Chain Ferritin in Complex with Cisplatin (pdb code 5n26). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 8 binding sites of Chlorine where determined in the X-Ray Structure of Human Heavy Chain Ferritin in Complex with Cisplatin, PDB code: 5n26:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Chlorine binding site 1 out of 8 in 5n26

Go back to Chlorine Binding Sites List in 5n26
Chlorine binding site 1 out of 8 in the X-Ray Structure of Human Heavy Chain Ferritin in Complex with Cisplatin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of X-Ray Structure of Human Heavy Chain Ferritin in Complex with Cisplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl203

b:38.1
occ:0.40
 CL1 A:CPT203 0.0 38.1 0.4
PT1 A:CPT203 2.3 47.7 0.4
O A:HOH446 3.1 42.7 1.0
PT1 A:73M202 3.2 55.9 0.4
OD2 A:ASP89 3.3 66.8 1.0
O A:HOH468 3.7 35.8 1.0
CZ3 A:TRP93 3.8 31.4 1.0
CB A:ASP89 3.9 48.7 1.0
SG A:CYS102 4.0 37.7 1.0
CH2 A:TRP93 4.0 32.5 1.0
CG A:ASP89 4.1 57.0 1.0
CB A:CYS102 4.1 24.7 1.0
PT1 A:CPT204 4.4 56.2 0.2
ND1 A:HIS105 4.6 38.3 0.5
CL1 A:CPT204 4.8 33.1 0.2
PT1 A:CPT203 4.9 50.9 0.2

Chlorine binding site 2 out of 8 in 5n26

Go back to Chlorine Binding Sites List in 5n26
Chlorine binding site 2 out of 8 in the X-Ray Structure of Human Heavy Chain Ferritin in Complex with Cisplatin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of X-Ray Structure of Human Heavy Chain Ferritin in Complex with Cisplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl204

b:33.1
occ:0.25
 CL1 A:CPT204 0.0 33.1 0.2
PT1 A:CPT204 2.3 56.2 0.2
PT1 A:CPT203 2.8 47.7 0.4
SG A:CYS90 3.1 20.8 0.5
CB A:CYS90 3.4 34.1 0.5
ND2 A:ASN98 3.5 20.0 1.0
SG A:CYS90 3.6 42.5 0.5
CB A:CYS90 3.8 29.1 0.5
SG A:CYS102 3.9 37.7 1.0
CE3 A:TRP93 3.9 26.8 1.0
CZ3 A:TRP93 4.1 31.4 1.0
O A:ASP92 4.2 33.5 1.0
CG A:ASN98 4.5 21.0 1.0
OE2 A:GLU94 4.6 64.3 1.0
OD1 A:ASN98 4.7 26.5 1.0
CA A:TRP93 4.8 27.5 1.0
CL1 A:CPT203 4.8 38.1 0.4
CD2 A:TRP93 4.8 23.2 1.0
CA A:CYS90 4.9 40.1 0.5

Chlorine binding site 3 out of 8 in 5n26

Go back to Chlorine Binding Sites List in 5n26
Chlorine binding site 3 out of 8 in the X-Ray Structure of Human Heavy Chain Ferritin in Complex with Cisplatin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of X-Ray Structure of Human Heavy Chain Ferritin in Complex with Cisplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl205

b:16.6
occ:0.25
 NE2 A:HIS173 3.1 28.8 1.0
CE1 A:HIS173 3.7 33.4 1.0
CD2 A:LEU169 4.0 12.9 1.0
CD2 A:HIS173 4.3 27.9 1.0
ND1 A:HIS173 4.9 31.9 1.0

Chlorine binding site 4 out of 8 in 5n26

Go back to Chlorine Binding Sites List in 5n26
Chlorine binding site 4 out of 8 in the X-Ray Structure of Human Heavy Chain Ferritin in Complex with Cisplatin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of X-Ray Structure of Human Heavy Chain Ferritin in Complex with Cisplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl206

b:24.3
occ:1.00
 N A:TYR12 3.2 12.6 1.0
O A:HOH477 3.3 45.1 1.0
O A:TYR12 3.4 12.9 1.0
N A:ASN11 3.4 17.2 1.0
CG A:ARG9 3.7 16.0 1.0
O A:HOH439 3.7 24.1 1.0
CD A:ARG9 3.7 17.1 1.0
NE A:ARG9 3.7 17.3 1.0
C A:GLN10 3.9 16.9 1.0
C A:TYR12 4.0 13.1 1.0
CA A:GLN10 4.0 16.5 1.0
CA A:ASN11 4.1 14.9 1.0
CA A:TYR12 4.1 12.8 1.0
N A:GLN10 4.1 16.2 1.0
C A:ASN11 4.1 13.2 1.0
C A:ARG9 4.4 16.8 1.0
CB A:TYR12 4.4 12.3 1.0
CB A:ARG9 4.5 16.1 1.0
O A:ARG9 4.6 14.5 1.0
O A:GLN10 4.8 16.1 1.0
CZ A:ARG9 5.0 17.9 1.0

Chlorine binding site 5 out of 8 in 5n26

Go back to Chlorine Binding Sites List in 5n26
Chlorine binding site 5 out of 8 in the X-Ray Structure of Human Heavy Chain Ferritin in Complex with Cisplatin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of X-Ray Structure of Human Heavy Chain Ferritin in Complex with Cisplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl207

b:27.3
occ:1.00
 ND2 A:ASN139 3.3 16.2 1.0
CD A:LYS143 3.8 21.8 1.0
OD1 A:ASN139 4.1 14.8 1.0
CG A:ASN139 4.1 18.0 1.0
CG A:LYS143 4.2 18.2 1.0

Chlorine binding site 6 out of 8 in 5n26

Go back to Chlorine Binding Sites List in 5n26
Chlorine binding site 6 out of 8 in the X-Ray Structure of Human Heavy Chain Ferritin in Complex with Cisplatin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of X-Ray Structure of Human Heavy Chain Ferritin in Complex with Cisplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl208

b:32.1
occ:1.00
 N A:GLN14 3.1 16.0 1.0
CG A:GLN14 3.5 31.5 1.0
CA A:HIS13 3.7 15.6 1.0
O A:HOH490 3.7 45.5 1.0
CD2 A:HIS13 3.8 19.1 1.0
CG A:HIS13 3.8 17.3 1.0
C A:HIS13 3.8 16.4 1.0
ND1 A:HIS13 3.8 18.5 1.0
CB A:GLN14 3.9 23.4 1.0
O A:HOH477 3.9 45.1 1.0
NE2 A:HIS13 3.9 17.7 1.0
CE1 A:HIS13 3.9 18.2 1.0
CA A:GLN14 4.1 18.1 1.0
CD A:GLN14 4.1 39.5 1.0
CB A:HIS13 4.4 16.6 1.0
O A:TYR12 4.5 12.9 1.0
OE1 A:GLN14 4.5 43.3 1.0
NE2 A:GLN14 4.7 47.5 1.0
N A:HIS13 4.9 15.1 1.0

Chlorine binding site 7 out of 8 in 5n26

Go back to Chlorine Binding Sites List in 5n26
Chlorine binding site 7 out of 8 in the X-Ray Structure of Human Heavy Chain Ferritin in Complex with Cisplatin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 7 of X-Ray Structure of Human Heavy Chain Ferritin in Complex with Cisplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl209

b:22.4
occ:0.20
 CE1 A:HIS173 3.9 33.4 1.0
ND1 A:HIS173 4.3 31.9 1.0

Chlorine binding site 8 out of 8 in 5n26

Go back to Chlorine Binding Sites List in 5n26
Chlorine binding site 8 out of 8 in the X-Ray Structure of Human Heavy Chain Ferritin in Complex with Cisplatin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 8 of X-Ray Structure of Human Heavy Chain Ferritin in Complex with Cisplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl210

b:28.8
occ:1.00
 NE2 A:GLN83 2.9 36.0 1.0
N A:ASP84 3.1 13.2 1.0
OD1 A:ASP84 3.5 12.8 1.0
CG A:ASP84 3.6 13.3 1.0
CB A:GLN83 3.6 20.4 1.0
CA A:GLN83 3.7 17.4 1.0
CB A:ASP84 3.9 12.9 1.0
C A:GLN83 3.9 15.4 1.0
OD2 A:ASP84 3.9 13.5 1.0
CD A:GLN83 4.0 35.7 1.0
CA A:ASP84 4.1 13.2 1.0
CG A:GLN83 4.3 26.2 1.0
O A:HOH338 4.4 18.1 1.0
O A:HOH318 4.6 19.5 0.5
O A:HOH371 4.7 16.1 1.0

Reference:

G.Ferraro, S.Ciambellotti, L.Messori, A.Merlino. Cisplatin Binding Sites in Human H-Chain Ferritin. Inorg Chem V. 56 9064 2017.
ISSN: ISSN 1520-510X
PubMed: 28737381
DOI: 10.1021/ACS.INORGCHEM.7B01072
Page generated: Fri Jul 26 13:10:38 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy