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Atomistry » Chlorine » PDB 5nkc-5nru » 5nn0 » |
Chlorine in PDB 5nn0: Crystal Structure of Hubche with N-((1-(2,3-Dihydro-1H-Inden-2-Yl) Piperidin-3-Yl)Methyl)-N-(2-(Dimethylamino)Ethyl)-2-Naphthamide.Enzymatic activity of Crystal Structure of Hubche with N-((1-(2,3-Dihydro-1H-Inden-2-Yl) Piperidin-3-Yl)Methyl)-N-(2-(Dimethylamino)Ethyl)-2-Naphthamide.
All present enzymatic activity of Crystal Structure of Hubche with N-((1-(2,3-Dihydro-1H-Inden-2-Yl) Piperidin-3-Yl)Methyl)-N-(2-(Dimethylamino)Ethyl)-2-Naphthamide.:
3.1.1.8; Protein crystallography data
The structure of Crystal Structure of Hubche with N-((1-(2,3-Dihydro-1H-Inden-2-Yl) Piperidin-3-Yl)Methyl)-N-(2-(Dimethylamino)Ethyl)-2-Naphthamide., PDB code: 5nn0
was solved by
N.Coquelle,
B.Brus,
J.P.Colletier,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Hubche with N-((1-(2,3-Dihydro-1H-Inden-2-Yl) Piperidin-3-Yl)Methyl)-N-(2-(Dimethylamino)Ethyl)-2-Naphthamide.
(pdb code 5nn0). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Crystal Structure of Hubche with N-((1-(2,3-Dihydro-1H-Inden-2-Yl) Piperidin-3-Yl)Methyl)-N-(2-(Dimethylamino)Ethyl)-2-Naphthamide., PDB code: 5nn0: Jump to Chlorine binding site number: 1; 2; 3; Chlorine binding site 1 out of 3 in 5nn0Go back to Chlorine Binding Sites List in 5nn0
Chlorine binding site 1 out
of 3 in the Crystal Structure of Hubche with N-((1-(2,3-Dihydro-1H-Inden-2-Yl) Piperidin-3-Yl)Methyl)-N-(2-(Dimethylamino)Ethyl)-2-Naphthamide.
Mono view Stereo pair view
Chlorine binding site 2 out of 3 in 5nn0Go back to Chlorine Binding Sites List in 5nn0
Chlorine binding site 2 out
of 3 in the Crystal Structure of Hubche with N-((1-(2,3-Dihydro-1H-Inden-2-Yl) Piperidin-3-Yl)Methyl)-N-(2-(Dimethylamino)Ethyl)-2-Naphthamide.
Mono view Stereo pair view
Chlorine binding site 3 out of 3 in 5nn0Go back to Chlorine Binding Sites List in 5nn0
Chlorine binding site 3 out
of 3 in the Crystal Structure of Hubche with N-((1-(2,3-Dihydro-1H-Inden-2-Yl) Piperidin-3-Yl)Methyl)-N-(2-(Dimethylamino)Ethyl)-2-Naphthamide.
Mono view Stereo pair view
Reference:
U.Kosak,
B.Brus,
D.Knez,
S.Zakelj,
J.Trontelj,
A.Pislar,
R.Sink,
M.Jukic,
M.Zivin,
A.Podkowa,
F.Nachon,
X.Brazzolotto,
J.Stojan,
J.Kos,
N.Coquelle,
K.Salat,
J.P.Colletier,
S.Gobec.
The Magic of Crystal Structure-Based Inhibitor Optimization: Development of A Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity. J. Med. Chem. V. 61 119 2018.
Page generated: Sat Dec 12 12:10:07 2020
ISSN: ISSN 1520-4804 PubMed: 29227101 DOI: 10.1021/ACS.JMEDCHEM.7B01086 |
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