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Chlorine in PDB 5sda: Crystal Structure of Dihydrofolate Reductase From Homo Sapiens Bound to Nadp and Sddc Inhibitor Sddc-774

Enzymatic activity of Crystal Structure of Dihydrofolate Reductase From Homo Sapiens Bound to Nadp and Sddc Inhibitor Sddc-774

All present enzymatic activity of Crystal Structure of Dihydrofolate Reductase From Homo Sapiens Bound to Nadp and Sddc Inhibitor Sddc-774:
1.5.1.3;

Protein crystallography data

The structure of Crystal Structure of Dihydrofolate Reductase From Homo Sapiens Bound to Nadp and Sddc Inhibitor Sddc-774, PDB code: 5sda was solved by Seattle Structural Genomics Center For Infectious Disease (Ssgcid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 49.34 / 2.45
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 74.3, 74.3, 143.63, 90, 90, 90
R / Rfree (%) 16.1 / 20.5

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Dihydrofolate Reductase From Homo Sapiens Bound to Nadp and Sddc Inhibitor Sddc-774 (pdb code 5sda). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Dihydrofolate Reductase From Homo Sapiens Bound to Nadp and Sddc Inhibitor Sddc-774, PDB code: 5sda:

Chlorine binding site 1 out of 1 in 5sda

Go back to Chlorine Binding Sites List in 5sda
Chlorine binding site 1 out of 1 in the Crystal Structure of Dihydrofolate Reductase From Homo Sapiens Bound to Nadp and Sddc Inhibitor Sddc-774


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Dihydrofolate Reductase From Homo Sapiens Bound to Nadp and Sddc Inhibitor Sddc-774 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl206

b:55.7
occ:1.00
 NH2 A:ARG138 3.1 25.8 1.0
NH1 A:ARG138 3.4 25.1 1.0
CE A:MET15 3.5 27.4 0.5
N A:ILE152 3.6 43.1 1.0
CZ A:ARG138 3.7 27.6 1.0
CG A:GLU151 3.9 73.0 1.0
CG1 A:ILE152 4.1 31.8 1.0
SD A:MET15 4.1 33.6 0.5
CB A:ILE152 4.1 34.2 1.0
CA A:GLU151 4.2 57.1 1.0
CD1 A:ILE152 4.3 33.7 1.0
C A:GLU151 4.4 47.9 1.0
CA A:ILE152 4.5 39.7 1.0
CB A:GLU151 4.6 68.5 1.0
O A:ILE152 5.0 42.7 1.0
NE A:ARG138 5.0 29.8 1.0

Reference:

S.J.Mayclin, J.W.Fairman, D.M.Dranow, D.G.Conrady, D.Fox Iii, C.M.Lukacs, D.D.Lorimer, P.S.Horanyi, T.E.Edwards, J.Abendroth. Crystal Structure of Dihydrofolate Reductase From Homo Sapiens Bound to Nadp and Sddc Inhibitor Sddc-774 To Be Published.
Page generated: Fri Jul 26 16:42:40 2024

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