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Chlorine in PDB 5t0l: Crystal Structure of Toxoplasma Gondii Ts-Dhfr Complexed with Nadph, Dump, Pddf and 5-(4-(3,4-Dichlorophenyl)Piperazin-1-Yl)Pyrimidine-2, 4-Diamine (Trc-15)Enzymatic activity of Crystal Structure of Toxoplasma Gondii Ts-Dhfr Complexed with Nadph, Dump, Pddf and 5-(4-(3,4-Dichlorophenyl)Piperazin-1-Yl)Pyrimidine-2, 4-Diamine (Trc-15)
All present enzymatic activity of Crystal Structure of Toxoplasma Gondii Ts-Dhfr Complexed with Nadph, Dump, Pddf and 5-(4-(3,4-Dichlorophenyl)Piperazin-1-Yl)Pyrimidine-2, 4-Diamine (Trc-15):
1.5.1.3; 2.1.1.45; Protein crystallography data
The structure of Crystal Structure of Toxoplasma Gondii Ts-Dhfr Complexed with Nadph, Dump, Pddf and 5-(4-(3,4-Dichlorophenyl)Piperazin-1-Yl)Pyrimidine-2, 4-Diamine (Trc-15), PDB code: 5t0l
was solved by
S.B.Thomas,
Z.Chen,
H.Lu,
Y.Li,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Toxoplasma Gondii Ts-Dhfr Complexed with Nadph, Dump, Pddf and 5-(4-(3,4-Dichlorophenyl)Piperazin-1-Yl)Pyrimidine-2, 4-Diamine (Trc-15)
(pdb code 5t0l). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Crystal Structure of Toxoplasma Gondii Ts-Dhfr Complexed with Nadph, Dump, Pddf and 5-(4-(3,4-Dichlorophenyl)Piperazin-1-Yl)Pyrimidine-2, 4-Diamine (Trc-15), PDB code: 5t0l: Jump to Chlorine binding site number: 1; 2; 3; 4; Chlorine binding site 1 out of 4 in 5t0lGo back to Chlorine Binding Sites List in 5t0l
Chlorine binding site 1 out
of 4 in the Crystal Structure of Toxoplasma Gondii Ts-Dhfr Complexed with Nadph, Dump, Pddf and 5-(4-(3,4-Dichlorophenyl)Piperazin-1-Yl)Pyrimidine-2, 4-Diamine (Trc-15)
Mono view Stereo pair view
Chlorine binding site 2 out of 4 in 5t0lGo back to Chlorine Binding Sites List in 5t0l
Chlorine binding site 2 out
of 4 in the Crystal Structure of Toxoplasma Gondii Ts-Dhfr Complexed with Nadph, Dump, Pddf and 5-(4-(3,4-Dichlorophenyl)Piperazin-1-Yl)Pyrimidine-2, 4-Diamine (Trc-15)
Mono view Stereo pair view
Chlorine binding site 3 out of 4 in 5t0lGo back to Chlorine Binding Sites List in 5t0l
Chlorine binding site 3 out
of 4 in the Crystal Structure of Toxoplasma Gondii Ts-Dhfr Complexed with Nadph, Dump, Pddf and 5-(4-(3,4-Dichlorophenyl)Piperazin-1-Yl)Pyrimidine-2, 4-Diamine (Trc-15)
Mono view Stereo pair view
Chlorine binding site 4 out of 4 in 5t0lGo back to Chlorine Binding Sites List in 5t0l
Chlorine binding site 4 out
of 4 in the Crystal Structure of Toxoplasma Gondii Ts-Dhfr Complexed with Nadph, Dump, Pddf and 5-(4-(3,4-Dichlorophenyl)Piperazin-1-Yl)Pyrimidine-2, 4-Diamine (Trc-15)
Mono view Stereo pair view
Reference:
M.E.Welsch,
J.Zhou,
Y.Gao,
Y.Yan,
G.Porter,
G.Agnihotri,
Y.Li,
H.Lu,
Z.Chen,
S.B.Thomas.
Discovery of Potent and Selective Leads Against Toxoplasma Gondii Dihydrofolate Reductase Via Structure-Based Design. Acs Med Chem Lett V. 7 1124 2016.
Page generated: Sat Dec 12 12:27:27 2020
ISSN: ISSN 1948-5875 PubMed: 27994750 DOI: 10.1021/ACSMEDCHEMLETT.6B00328 |
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