Chlorine in PDB 5td9: Structure of Human Enolase 2

All present enzymatic activity of Structure of Human Enolase 2:
4.2.1.11;

The structure of Structure of Human Enolase 2, PDB code: 5td9 was solved by P.G.Leonard, F.L.Muller, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.51 / 2.32
Space group	P 2 21 21
Cell size a, b, c (Å), α, β, γ (°)	68.319, 112.868, 119.922, 90.00, 90.00, 90.00
R / Rfree (%)	20 / 24.5

The structure of Structure of Human Enolase 2 also contains other interesting chemical elements:

Magnesium

(Mg)

2 atoms

The binding sites of Chlorine atom in the Structure of Human Enolase 2 (pdb code 5td9). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Structure of Human Enolase 2, PDB code: 5td9:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Structure of Human Enolase 2


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of Human Enolase 2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl502 b:66.3 occ:1.00 OG A:SER373 3.5 62.0 1.0 NZ A:LYS343 3.6 49.4 1.0 NE A:ARG372 3.8 45.0 1.0 NH2 A:ARG372 3.8 49.9 1.0 N A:SER373 3.9 38.8 1.0 CB A:SER373 4.2 47.4 1.0 CZ A:ARG372 4.3 49.5 1.0 O A:HOH633 4.4 54.4 1.0 CE A:LYS343 4.5 46.6 1.0 O A:HOH638 4.6 47.8 1.0 O A:HOH636 4.6 62.2 1.0 CA A:ARG372 4.7 40.3 1.0 CA A:SER373 4.7 43.3 1.0 C A:ARG372 4.8 35.0 1.0 CD A:ARG372 4.9 37.7 1.0 CB A:ARG372 5.0 35.0 1.0

Chlorine binding site 2 out of 2 in the Structure of Human Enolase 2


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structure of Human Enolase 2 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl502 b:83.6 occ:1.00 NE B:ARG372 3.3 46.2 1.0 N B:SER373 3.4 34.8 1.0 NH2 B:ARG372 3.6 48.3 1.0 OG B:SER373 3.8 49.9 1.0 NZ B:LYS343 3.8 36.2 1.0 CZ B:ARG372 3.9 49.9 1.0 CB B:SER373 3.9 37.1 1.0 CA B:ARG372 4.1 31.1 1.0 C B:ARG372 4.2 33.3 1.0 CA B:SER373 4.3 37.4 1.0 CD B:ARG372 4.4 38.8 1.0 CB B:ARG372 4.4 29.5 1.0 O B:HOH638 4.5 38.0 1.0 CE B:LYS343 4.8 30.5 1.0

Y.H.Lin, N.Satani, N.Hammoudi, F.Felini, P.G.Leonard, D.Maxwell, Z.Peng, T.M.Link, G.R.Lee, A.Bosajou, D.Sun, J.R.Marszalek, Y.T.Sun, J.Mcmurray, P.J.Mandal, R.Zielinski, W.Priebe, M.E.Difrancesco, B.Czako, Y.A.Wang, W.Bornmann, R.A.Depinho, F.L.Muller. Pomhex, A Cell-Permeable Enolase Inhibitor For Collateral Lethality Targeting of ENO1-Deleted Glioblastoma To Be Published.