Chlorine in PDB 5td9: Structure of Human Enolase 2

Enzymatic activity of Structure of Human Enolase 2

All present enzymatic activity of Structure of Human Enolase 2:
4.2.1.11;

Protein crystallography data

The structure of Structure of Human Enolase 2, PDB code: 5td9 was solved by P.G.Leonard, F.L.Muller, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 43.51 / 2.32
Space group P 2 21 21
Cell size a, b, c (Å), α, β, γ (°) 68.319, 112.868, 119.922, 90.00, 90.00, 90.00
R / Rfree (%) 20 / 24.5

Other elements in 5td9:

The structure of Structure of Human Enolase 2 also contains other interesting chemical elements:

Magnesium (Mg) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Structure of Human Enolase 2 (pdb code 5td9). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Structure of Human Enolase 2, PDB code: 5td9:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in 5td9

Go back to Chlorine Binding Sites List in 5td9
Chlorine binding site 1 out of 2 in the Structure of Human Enolase 2


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of Human Enolase 2 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl502

b:66.3
occ:1.00
OG A:SER373 3.5 62.0 1.0
NZ A:LYS343 3.6 49.4 1.0
NE A:ARG372 3.8 45.0 1.0
NH2 A:ARG372 3.8 49.9 1.0
N A:SER373 3.9 38.8 1.0
CB A:SER373 4.2 47.4 1.0
CZ A:ARG372 4.3 49.5 1.0
O A:HOH633 4.4 54.4 1.0
CE A:LYS343 4.5 46.6 1.0
O A:HOH638 4.6 47.8 1.0
O A:HOH636 4.6 62.2 1.0
CA A:ARG372 4.7 40.3 1.0
CA A:SER373 4.7 43.3 1.0
C A:ARG372 4.8 35.0 1.0
CD A:ARG372 4.9 37.7 1.0
CB A:ARG372 5.0 35.0 1.0

Chlorine binding site 2 out of 2 in 5td9

Go back to Chlorine Binding Sites List in 5td9
Chlorine binding site 2 out of 2 in the Structure of Human Enolase 2


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structure of Human Enolase 2 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl502

b:83.6
occ:1.00
NE B:ARG372 3.3 46.2 1.0
N B:SER373 3.4 34.8 1.0
NH2 B:ARG372 3.6 48.3 1.0
OG B:SER373 3.8 49.9 1.0
NZ B:LYS343 3.8 36.2 1.0
CZ B:ARG372 3.9 49.9 1.0
CB B:SER373 3.9 37.1 1.0
CA B:ARG372 4.1 31.1 1.0
C B:ARG372 4.2 33.3 1.0
CA B:SER373 4.3 37.4 1.0
CD B:ARG372 4.4 38.8 1.0
CB B:ARG372 4.4 29.5 1.0
O B:HOH638 4.5 38.0 1.0
CE B:LYS343 4.8 30.5 1.0

Reference:

Y.H.Lin, N.Satani, N.Hammoudi, F.Felini, P.G.Leonard, D.Maxwell, Z.Peng, T.M.Link, G.R.Lee, A.Bosajou, D.Sun, J.R.Marszalek, Y.T.Sun, J.Mcmurray, P.J.Mandal, R.Zielinski, W.Priebe, M.E.Difrancesco, B.Czako, Y.A.Wang, W.Bornmann, R.A.Depinho, F.L.Muller. Pomhex, A Cell-Permeable Enolase Inhibitor For Collateral Lethality Targeting of ENO1-Deleted Glioblastoma To Be Published.
Page generated: Sat Dec 12 12:28:11 2020

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