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Chlorine in PDB 5ter: Crystal Structure of Hiv-1 Reverse Transcriptase in Complex with 5- Chloro-7-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl)Ethoxy) Phenoxy)-8-Methyl-2-Naphthonitrile (JLJ651), A Non-Nucleoside InhibitorEnzymatic activity of Crystal Structure of Hiv-1 Reverse Transcriptase in Complex with 5- Chloro-7-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl)Ethoxy) Phenoxy)-8-Methyl-2-Naphthonitrile (JLJ651), A Non-Nucleoside Inhibitor
All present enzymatic activity of Crystal Structure of Hiv-1 Reverse Transcriptase in Complex with 5- Chloro-7-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl)Ethoxy) Phenoxy)-8-Methyl-2-Naphthonitrile (JLJ651), A Non-Nucleoside Inhibitor:
2.7.7.49; 2.7.7.7; 3.1.13.2; 3.1.26.13; 3.4.23.16; Protein crystallography data
The structure of Crystal Structure of Hiv-1 Reverse Transcriptase in Complex with 5- Chloro-7-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl)Ethoxy) Phenoxy)-8-Methyl-2-Naphthonitrile (JLJ651), A Non-Nucleoside Inhibitor, PDB code: 5ter
was solved by
A.H.Chan,
K.S.Anderson,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5ter:
The structure of Crystal Structure of Hiv-1 Reverse Transcriptase in Complex with 5- Chloro-7-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl)Ethoxy) Phenoxy)-8-Methyl-2-Naphthonitrile (JLJ651), A Non-Nucleoside Inhibitor also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Hiv-1 Reverse Transcriptase in Complex with 5- Chloro-7-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl)Ethoxy) Phenoxy)-8-Methyl-2-Naphthonitrile (JLJ651), A Non-Nucleoside Inhibitor
(pdb code 5ter). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Hiv-1 Reverse Transcriptase in Complex with 5- Chloro-7-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl)Ethoxy) Phenoxy)-8-Methyl-2-Naphthonitrile (JLJ651), A Non-Nucleoside Inhibitor, PDB code: 5ter: Chlorine binding site 1 out of 1 in 5terGo back to Chlorine Binding Sites List in 5ter
Chlorine binding site 1 out
of 1 in the Crystal Structure of Hiv-1 Reverse Transcriptase in Complex with 5- Chloro-7-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl)Ethoxy) Phenoxy)-8-Methyl-2-Naphthonitrile (JLJ651), A Non-Nucleoside Inhibitor
Mono view Stereo pair view
Reference:
W.G.Lee,
A.H.Chan,
K.A.Spasov,
K.S.Anderson,
W.L.Jorgensen.
Design, Conformation, and Crystallography of 2-Naphthyl Phenyl Ethers As Potent Anti-Hiv Agents. Acs Med Chem Lett V. 7 1156 2016.
Page generated: Sat Dec 12 12:28:20 2020
ISSN: ISSN 1948-5875 PubMed: 27994756 DOI: 10.1021/ACSMEDCHEMLETT.6B00390 |
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