Chlorine in PDB 5tpx: Bromodomain From Plasmodium Faciparum GCN5, Complexed with Compound

All present enzymatic activity of Bromodomain From Plasmodium Faciparum GCN5, Complexed with Compound:
2.3.1.48;

The structure of Bromodomain From Plasmodium Faciparum GCN5, Complexed with Compound, PDB code: 5tpx was solved by Y.H.Lin, C.F.D.Hou, M.Moustakim, D.J.Dixon, P.Loppnau, W.Tempel, C.Bountra, A.M.Edwards, C.H.Arrowsmith, R.Hui, P.E.Brennan, J.R.Walker, Structuralgenomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	37.50 / 2.10
Space group	P 4 21 2
Cell size a, b, c (Å), α, β, γ (°)	75.000, 75.000, 49.620, 90.00, 90.00, 90.00
R / Rfree (%)	18.5 / 23.6

The binding sites of Chlorine atom in the Bromodomain From Plasmodium Faciparum GCN5, Complexed with Compound (pdb code 5tpx). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Bromodomain From Plasmodium Faciparum GCN5, Complexed with Compound, PDB code: 5tpx:

Chlorine binding site 1 out of 1 in the Bromodomain From Plasmodium Faciparum GCN5, Complexed with Compound


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Bromodomain From Plasmodium Faciparum GCN5, Complexed with Compound within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1501 b:90.2 occ:1.00 NH2 A:ARG1408 3.9 66.4 1.0 NE A:ARG1408 4.3 64.5 1.0 CZ A:ARG1408 4.6 80.3 1.0 NH2 A:ARG1411 4.6 63.0 1.0

M.Moustakim, P.G.Clark, L.Trulli, A.L.Fuentes De Arriba, M.T.Ehebauer, A.Chaikuad, E.J.Murphy, J.Mendez-Johnson, D.Daniels, C.D.Hou, Y.H.Lin, J.R.Walker, R.Hui, H.Yang, L.Dorrell, C.M.Rogers, O.P.Monteiro, O.Fedorov, K.V.Huber, S.Knapp, J.Heer, D.J.Dixon, P.E.Brennan. Discovery of A Pcaf Bromodomain Chemical Probe. Angew. Chem. Int. Ed. Engl. V. 56 827 2017.
ISSN: ESSN 1521-3773
PubMed: 27966810
DOI: 10.1002/ANIE.201610816