Chlorine in PDB 5tvp: SUMO2 Bound to Mouse TDP2 Catalytic Domain with A 5'-Phosphorylated Dna Ternary Complex

The structure of SUMO2 Bound to Mouse TDP2 Catalytic Domain with A 5'-Phosphorylated Dna Ternary Complex, PDB code: 5tvp was solved by M.J.Schellenberg, R.S.Williams, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.27 / 2.40
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	106.547, 113.772, 125.434, 90.00, 91.52, 90.00
R / Rfree (%)	19.1 / 23.3

The binding sites of Chlorine atom in the SUMO2 Bound to Mouse TDP2 Catalytic Domain with A 5'-Phosphorylated Dna Ternary Complex (pdb code 5tvp). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the SUMO2 Bound to Mouse TDP2 Catalytic Domain with A 5'-Phosphorylated Dna Ternary Complex, PDB code: 5tvp:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in the SUMO2 Bound to Mouse TDP2 Catalytic Domain with A 5'-Phosphorylated Dna Ternary Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of SUMO2 Bound to Mouse TDP2 Catalytic Domain with A 5'-Phosphorylated Dna Ternary Complex within 5.0Å range: probe atom residue distance (Å) B Occ E:Cl402 b:49.2 occ:1.00 O K:HOH506 3.3 26.7 1.0 N E:LYS349 3.9 35.6 1.0 O E:HOH575 3.9 42.6 1.0 O E:LEU347 4.1 38.9 1.0 CB E:LYS349 4.2 39.7 1.0 CD2 K:LEU347 4.2 31.9 1.0 O E:HOH601 4.4 46.1 1.0 CD1 K:LEU344 4.4 32.3 1.0 O K:HOH540 4.4 34.9 1.0 CA E:GLU348 4.5 30.5 1.0 CA E:LYS349 4.7 34.3 1.0 C E:GLU348 4.7 31.3 1.0 CD1 K:LEU347 4.8 36.3 1.0

Chlorine binding site 2 out of 3 in the SUMO2 Bound to Mouse TDP2 Catalytic Domain with A 5'-Phosphorylated Dna Ternary Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of SUMO2 Bound to Mouse TDP2 Catalytic Domain with A 5'-Phosphorylated Dna Ternary Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl403 b:61.2 occ:1.00 N B:LYS349 3.8 32.5 1.0 O B:LEU347 4.1 31.1 1.0 O B:HOH588 4.1 39.3 1.0 CA B:GLU348 4.2 31.7 1.0 CB B:LYS349 4.3 41.2 1.0 O B:HOH508 4.4 23.8 1.0 O B:HOH581 4.5 56.9 1.0 C B:GLU348 4.6 34.6 1.0 CA B:LYS349 4.7 32.4 1.0 CG B:GLU348 4.8 33.5 1.0 C B:LEU347 5.0 30.5 1.0

Chlorine binding site 3 out of 3 in the SUMO2 Bound to Mouse TDP2 Catalytic Domain with A 5'-Phosphorylated Dna Ternary Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of SUMO2 Bound to Mouse TDP2 Catalytic Domain with A 5'-Phosphorylated Dna Ternary Complex within 5.0Å range: probe atom residue distance (Å) B Occ M:Cl402 b:56.3 occ:1.00 N M:LYS349 3.6 45.0 1.0 O M:LEU347 3.8 37.5 1.0 O M:HOH501 4.0 29.0 1.0 CB M:LYS349 4.1 46.6 1.0 CA M:GLU348 4.2 38.2 1.0 C M:GLU348 4.4 38.7 1.0 CA M:LYS349 4.5 47.4 1.0 C M:LEU347 4.8 37.5 1.0 CG M:GLU348 4.9 40.0 1.0 N M:GLU348 5.0 37.8 1.0

M.J.Schellenberg, J.A.Lieberman, A.Herrero-Ruiz, L.R.Butler, J.G.Williams, A.M.Munoz-Cabello, G.A.Mueller, R.E.London, F.Cortes-Ledesma, R.S.Williams. Zatt (ZNF451)-Mediated Resolution of Topoisomerase 2 Dna-Protein Cross-Links. Science V. 357 1412 2017.
ISSN: ESSN 1095-9203
PubMed: 28912134
DOI: 10.1126/SCIENCE.AAM6468