Chlorine in PDB 5twl: Structure of Maternal Embryonic Leucine Zipper Kinase

All present enzymatic activity of Structure of Maternal Embryonic Leucine Zipper Kinase:
2.7.10.2; 2.7.11.1;

The structure of Structure of Maternal Embryonic Leucine Zipper Kinase, PDB code: 5twl was solved by H.-S.Seo, H.-T.Huang, N.S.Gray, S.Dhe-Paganon, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	38.77 / 2.42
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	57.520, 68.300, 104.950, 90.00, 90.00, 90.00
R / Rfree (%)	19.6 / 24.9

The binding sites of Chlorine atom in the Structure of Maternal Embryonic Leucine Zipper Kinase (pdb code 5twl). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Structure of Maternal Embryonic Leucine Zipper Kinase, PDB code: 5twl:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Structure of Maternal Embryonic Leucine Zipper Kinase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of Maternal Embryonic Leucine Zipper Kinase within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl4000 b:65.8 occ:1.00 CL A:H914000 0.0 65.8 1.0 C22 A:H914000 1.7 59.5 1.0 C21 A:H914000 2.7 55.3 1.0 C23 A:H914000 2.7 58.3 1.0 O1 A:H914000 2.9 54.4 1.0 CE A:LYS40 3.5 54.3 1.0 NZ A:LYS40 3.5 51.8 1.0 CD A:LYS40 3.6 52.3 1.0 C20 A:H914000 4.0 56.0 1.0 C24 A:H914000 4.0 62.7 1.0 C4 A:H914000 4.3 40.7 1.0 C25 A:H914000 4.5 60.3 1.0 CG A:LYS40 4.5 48.8 1.0 CG2 A:VAL25 4.6 51.0 1.0 C5 A:H914000 4.8 40.4 1.0

Chlorine binding site 2 out of 2 in the Structure of Maternal Embryonic Leucine Zipper Kinase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structure of Maternal Embryonic Leucine Zipper Kinase within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl4000 b:66.9 occ:1.00 CL1 A:H914000 0.0 66.9 1.0 C24 A:H914000 1.7 62.7 1.0 C25 A:H914000 2.7 60.3 1.0 C23 A:H914000 2.7 58.3 1.0 O1 A:H914000 3.0 54.4 1.0 OE1 A:GLU57 3.1 66.3 1.0 N A:ASP150 3.5 49.1 1.0 CD1 A:LEU61 3.8 48.3 1.0 CD2 A:LEU86 3.9 33.3 1.0 C20 A:H914000 4.0 56.0 1.0 C22 A:H914000 4.0 59.5 1.0 CB A:ILE149 4.0 43.9 1.0 CD A:GLU57 4.1 64.6 1.0 CA A:ILE149 4.1 40.9 1.0 CD1 A:LEU86 4.3 41.0 1.0 C A:ILE149 4.3 43.4 1.0 CA A:ASP150 4.3 53.6 1.0 C21 A:H914000 4.5 55.3 1.0 CB A:CYS70 4.6 45.5 1.0 CG2 A:ILE149 4.6 38.1 1.0 CG A:LEU86 4.7 38.8 1.0 SG A:CYS70 4.7 45.3 1.0 CG A:LEU61 4.7 43.5 1.0 OE2 A:GLU57 4.8 65.9 1.0 CD2 A:LEU61 4.8 38.3 1.0 CG A:GLU57 4.9 57.8 1.0 CE A:MET84 5.0 51.2 1.0 N A:PHE151 5.0 52.8 1.0

H.T.Huang, H.S.Seo, T.Zhang, Y.Wang, B.Jiang, Q.Li, D.L.Buckley, B.Nabet, J.M.Roberts, J.Paulk, S.Dastjerdi, G.E.Winter, H.Mclauchlan, J.Moran, J.E.Bradner, M.J.Eck, S.Dhe-Paganon, J.J.Zhao, N.S.Gray. Melk Is Not Necessary For the Proliferation of Basal-Like Breast Cancer Cells. Elife V. 6 2017.
ISSN: ESSN 2050-084X
PubMed: 28926338
DOI: 10.7554/ELIFE.26693