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Chlorine in PDB 5u6b: Structure of the Axl Kinase Domain in Complex with A Macrocyclic Inhibitor
Enzymatic activity of Structure of the Axl Kinase Domain in Complex with A Macrocyclic Inhibitor
All present enzymatic activity of Structure of the Axl Kinase Domain in Complex with A Macrocyclic Inhibitor:
2.7.10.1;
2.7.10.1;
Protein crystallography data
The structure of Structure of the Axl Kinase Domain in Complex with A Macrocyclic Inhibitor, PDB code: 5u6b
was solved by
K.S.Gajiwala,
N.Grodsky,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 59.81 / 2.84 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 81.680, 100.704, 81.921, 90.00, 93.97, 90.00 |
| R / Rfree (%) | 21.1 / 23.9 |
Other elements in 5u6b:
The structure of Structure of the Axl Kinase Domain in Complex with A Macrocyclic Inhibitor also contains other interesting chemical elements:
| Fluorine | (F) | 4 atoms |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Structure of the Axl Kinase Domain in Complex with A Macrocyclic Inhibitor
(pdb code 5u6b). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Structure of the Axl Kinase Domain in Complex with A Macrocyclic Inhibitor, PDB code: 5u6b:
Jump to Chlorine binding site number: 1; 2; 3; 4;
In total 4 binding sites of Chlorine where determined in the Structure of the Axl Kinase Domain in Complex with A Macrocyclic Inhibitor, PDB code: 5u6b:
Jump to Chlorine binding site number: 1; 2; 3; 4;
Chlorine binding site 1 out of 4 in 5u6b
Go back to
Chlorine Binding Sites List in 5u6b
Chlorine binding site 1 out
of 4 in the Structure of the Axl Kinase Domain in Complex with A Macrocyclic Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Structure of the Axl Kinase Domain in Complex with A Macrocyclic Inhibitor within 5.0Å range:
|
Chlorine binding site 2 out of 4 in 5u6b
Go back to
Chlorine Binding Sites List in 5u6b
Chlorine binding site 2 out
of 4 in the Structure of the Axl Kinase Domain in Complex with A Macrocyclic Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Structure of the Axl Kinase Domain in Complex with A Macrocyclic Inhibitor within 5.0Å range:
|
Chlorine binding site 3 out of 4 in 5u6b
Go back to
Chlorine Binding Sites List in 5u6b
Chlorine binding site 3 out
of 4 in the Structure of the Axl Kinase Domain in Complex with A Macrocyclic Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 3 of Structure of the Axl Kinase Domain in Complex with A Macrocyclic Inhibitor within 5.0Å range:
|
Chlorine binding site 4 out of 4 in 5u6b
Go back to
Chlorine Binding Sites List in 5u6b
Chlorine binding site 4 out
of 4 in the Structure of the Axl Kinase Domain in Complex with A Macrocyclic Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 4 of Structure of the Axl Kinase Domain in Complex with A Macrocyclic Inhibitor within 5.0Å range:
|
Reference:
K.S.Gajiwala,
N.Grodsky,
B.Bolanos,
J.Feng,
R.Ferre,
S.Timofeevski,
M.Xu,
B.W.Murray,
T.W.Johnson,
A.Stewart.
The Axl Kinase Domain in Complex with A Macrocyclic Inhibitor Offers First Structural Insights Into An Active Tam Receptor Kinase. J. Biol. Chem. V. 292 15705 2017.
ISSN: ESSN 1083-351X
PubMed: 28724631
DOI: 10.1074/JBC.M116.771485
Page generated: Sat Jul 12 09:14:58 2025
ISSN: ESSN 1083-351X
PubMed: 28724631
DOI: 10.1074/JBC.M116.771485
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