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Chlorine in PDB 5u7k: PDE2 Catalytic Domain Complexed with InhibitorsEnzymatic activity of PDE2 Catalytic Domain Complexed with Inhibitors
All present enzymatic activity of PDE2 Catalytic Domain Complexed with Inhibitors:
3.1.4.17; Protein crystallography data
The structure of PDE2 Catalytic Domain Complexed with Inhibitors, PDB code: 5u7k
was solved by
J.Pandit,
K.Parris,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5u7k:
The structure of PDE2 Catalytic Domain Complexed with Inhibitors also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the PDE2 Catalytic Domain Complexed with Inhibitors
(pdb code 5u7k). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the PDE2 Catalytic Domain Complexed with Inhibitors, PDB code: 5u7k: Chlorine binding site 1 out of 1 in 5u7kGo back to Chlorine Binding Sites List in 5u7k
Chlorine binding site 1 out
of 1 in the PDE2 Catalytic Domain Complexed with Inhibitors
Mono view Stereo pair view
Reference:
C.J.Helal,
E.P.Arnold,
T.L.Boyden,
C.Chang,
T.A.Chappie,
K.F.Fennell,
M.D.Forman,
M.Hajos,
J.F.Harms,
W.E.Hoffman,
J.M.Humphrey,
Z.Kang,
R.J.Kleiman,
B.L.Kormos,
C.W.Lee,
J.Lu,
N.Maklad,
L.Mcdowell,
S.Mente,
R.E.O'connor,
J.Pandit,
M.Piotrowski,
A.W.Schmidt,
C.J.Schmidt,
H.Ueno,
P.R.Verhoest,
E.X.Yang.
Application of Structure-Based Design and Parallel Chemistry to Identify A Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor. J. Med. Chem. V. 60 5673 2017.
Page generated: Sat Dec 12 12:30:32 2020
ISSN: ISSN 1520-4804 PubMed: 28574706 DOI: 10.1021/ACS.JMEDCHEM.7B00397 |
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