Chlorine in PDB 5uab: Met Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of An Hgf Antibody

All present enzymatic activity of Met Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of An Hgf Antibody:
2.7.10.1;

The structure of Met Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of An Hgf Antibody, PDB code: 5uab was solved by I.D.Hoffman, J.D.Lawson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	25.00 / 1.90
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	42.333, 47.167, 159.821, 90.00, 90.00, 90.00
R / Rfree (%)	19.5 / 22.9

The binding sites of Chlorine atom in the Met Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of An Hgf Antibody (pdb code 5uab). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Met Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of An Hgf Antibody, PDB code: 5uab:

Chlorine binding site 1 out of 1 in the Met Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of An Hgf Antibody


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Met Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of An Hgf Antibody within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1403 b:27.5 occ:1.00 O A:HOH1562 3.1 28.3 1.0 N A:HIS1348 3.3 34.7 1.0 N A:GLY1346 3.3 32.5 1.0 N A:GLU1347 3.3 36.8 1.0 CA A:GLY1346 3.3 34.2 1.0 N A:LYS1179 3.4 26.1 1.0 C A:GLY1346 3.6 35.9 1.0 N A:VAL1178 3.7 25.3 1.0 CB A:HIS1348 3.8 35.1 1.0 CB A:VAL1178 3.8 26.3 1.0 CB A:LYS1179 3.8 28.0 1.0 CD2 A:PHE1344 3.9 26.9 1.0 O A:HIS1348 3.9 30.9 1.0 CB A:THR1177 3.9 27.1 1.0 CB A:PHE1344 4.0 26.1 1.0 CA A:HIS1348 4.0 34.4 1.0 CA A:VAL1178 4.1 25.4 1.0 CA A:LYS1179 4.2 26.5 1.0 CD2 A:HIS1348 4.2 39.7 1.0 C A:VAL1178 4.2 24.9 1.0 OG1 A:THR1177 4.2 24.8 1.0 C A:GLU1347 4.3 36.8 1.0 CG A:PHE1344 4.3 26.4 1.0 CG A:HIS1348 4.3 38.2 1.0 C A:HIS1348 4.3 32.9 1.0 CA A:GLU1347 4.3 39.4 1.0 N A:ILE1345 4.5 30.3 1.0 C A:ILE1345 4.5 33.3 1.0 C A:THR1177 4.6 25.1 1.0 CG2 A:VAL1178 4.6 27.0 1.0 O A:GLY1346 4.7 37.3 1.0 CG2 A:THR1177 4.7 28.2 1.0 CA A:THR1177 4.8 26.1 1.0 CG1 A:VAL1178 4.8 25.7 1.0 CE2 A:PHE1344 4.9 26.7 1.0 CA A:PHE1344 4.9 27.9 1.0 C A:PHE1344 5.0 29.2 1.0

P.J.Farrell, J.Matuszkiewicz, D.Balakrishna, S.Pandya, M.S.Hixon, R.Kamran, S.Chu, J.D.Lawson, K.Okada, A.Hori, A.Mizutani, H.Iwata, R.De Jong, B.Hibner, P.Vincent. Met Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of An Hgf Antibody. Mol. Cancer Ther. V. 16 1269 2017.
ISSN: ESSN 1538-8514
PubMed: 28341789
DOI: 10.1158/1535-7163.MCT-16-0771