Chlorine in PDB 5uwx: Crystal Structure of Inosine 5'-Monophosphate Dehydrogenase From Clostridium Perfringens Complexed with Imp and P176

Enzymatic activity of Crystal Structure of Inosine 5'-Monophosphate Dehydrogenase From Clostridium Perfringens Complexed with Imp and P176

All present enzymatic activity of Crystal Structure of Inosine 5'-Monophosphate Dehydrogenase From Clostridium Perfringens Complexed with Imp and P176:
1.1.1.205;

Protein crystallography data

The structure of Crystal Structure of Inosine 5'-Monophosphate Dehydrogenase From Clostridium Perfringens Complexed with Imp and P176, PDB code: 5uwx was solved by N.Maltseva, Y.Kim, R.Mulligan, M.Makowska-Grzyska, M.Gu, D.R.Gollapalli, L.Hedstrom, A.Joachimiak, W.F.Anderson, Center For Structural Genomicsof Infectious Diseases (Csgid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 47.50 / 1.85
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 128.278, 118.943, 96.992, 90.00, 102.88, 90.00
R / Rfree (%) 16.3 / 19.7

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Inosine 5'-Monophosphate Dehydrogenase From Clostridium Perfringens Complexed with Imp and P176 (pdb code 5uwx). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Crystal Structure of Inosine 5'-Monophosphate Dehydrogenase From Clostridium Perfringens Complexed with Imp and P176, PDB code: 5uwx:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in 5uwx

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Chlorine binding site 1 out of 4 in the Crystal Structure of Inosine 5'-Monophosphate Dehydrogenase From Clostridium Perfringens Complexed with Imp and P176


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Inosine 5'-Monophosphate Dehydrogenase From Clostridium Perfringens Complexed with Imp and P176 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl500

b:42.2
occ:0.72
 CL A:8L7500 0.0 42.2 0.7
C20 A:8L7500 1.8 43.9 0.7
C21 A:8L7500 2.8 48.9 0.7
C19 A:8L7500 2.8 42.4 0.7
N34 A:8L7500 3.0 59.0 0.7
O B:GLY439 3.3 35.8 1.0
C B:GLY439 3.3 33.1 1.0
CA B:GLY439 3.6 32.4 1.0
CD2 A:HIS249 3.8 33.4 1.0
N B:TYR440 3.9 30.3 1.0
CD B:PRO25 4.0 48.7 1.0
C22 A:8L7500 4.1 45.6 0.7
C18 A:8L7500 4.1 44.7 0.7
O B:VAL23 4.1 55.1 1.0
CB A:HIS249 4.1 32.9 1.0
CG A:HIS249 4.3 31.4 1.0
C24 A:8L7500 4.3 69.1 0.7
CG B:PRO25 4.3 47.1 1.0
OG B:SER21 4.3 41.7 1.0
CA B:TYR440 4.5 33.0 1.0
C17 A:8L7500 4.6 43.5 0.7
O3 A:8L7500 4.6 73.4 0.7
CB B:SER21 4.8 40.7 1.0
N B:PRO25 4.9 51.8 1.0
N B:GLY439 4.9 31.3 1.0
CA B:LEU24 4.9 60.8 1.0

Chlorine binding site 2 out of 4 in 5uwx

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Chlorine binding site 2 out of 4 in the Crystal Structure of Inosine 5'-Monophosphate Dehydrogenase From Clostridium Perfringens Complexed with Imp and P176


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Inosine 5'-Monophosphate Dehydrogenase From Clostridium Perfringens Complexed with Imp and P176 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl500

b:44.9
occ:1.00
 CL B:8L7500 0.0 44.9 1.0
C20 B:8L7500 1.8 45.6 1.0
C21 B:8L7500 2.8 44.9 1.0
C19 B:8L7500 2.8 40.5 1.0
N34 B:8L7500 3.0 54.4 1.0
CD2 B:HIS249 3.6 26.9 1.0
CB B:HIS249 3.9 28.4 1.0
C22 B:8L7500 4.1 42.2 1.0
C18 B:8L7500 4.1 41.0 1.0
CG B:HIS249 4.1 27.8 1.0
C24 B:8L7500 4.2 70.2 1.0
O3 B:8L7500 4.5 76.8 1.0
C17 B:8L7500 4.6 40.3 1.0
NE2 B:HIS249 4.9 25.5 1.0
C27 B:8L7500 4.9 81.7 1.0

Chlorine binding site 3 out of 4 in 5uwx

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Chlorine binding site 3 out of 4 in the Crystal Structure of Inosine 5'-Monophosphate Dehydrogenase From Clostridium Perfringens Complexed with Imp and P176


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of Inosine 5'-Monophosphate Dehydrogenase From Clostridium Perfringens Complexed with Imp and P176 within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl500

b:56.6
occ:1.00
 CL C:8L7500 0.0 56.6 1.0
C20 C:8L7500 1.8 56.9 1.0
C19 C:8L7500 2.8 53.9 1.0
C21 C:8L7500 2.8 60.0 1.0
N34 C:8L7500 3.1 67.1 1.0
CD2 C:HIS249 3.7 38.1 1.0
CB C:HIS249 4.0 42.6 1.0
C18 C:8L7500 4.1 54.2 1.0
C22 C:8L7500 4.1 55.5 1.0
CG C:HIS249 4.2 37.9 1.0
C24 C:8L7500 4.3 82.1 1.0
O3 C:8L7500 4.6 89.0 1.0
C17 C:8L7500 4.6 52.3 1.0
NE2 C:HIS249 4.9 36.7 1.0

Chlorine binding site 4 out of 4 in 5uwx

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Chlorine binding site 4 out of 4 in the Crystal Structure of Inosine 5'-Monophosphate Dehydrogenase From Clostridium Perfringens Complexed with Imp and P176


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structure of Inosine 5'-Monophosphate Dehydrogenase From Clostridium Perfringens Complexed with Imp and P176 within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl500

b:51.2
occ:0.78
 CL D:8L7500 0.0 51.2 0.8
C20 D:8L7500 1.8 52.6 0.8
C19 D:8L7500 2.7 47.3 0.8
C21 D:8L7500 2.9 54.7 0.8
C24 D:8L7500 3.2 75.0 0.8
N34 D:8L7500 3.4 65.3 0.8
O3 D:8L7500 3.5 78.0 0.8
CD2 D:HIS249 3.6 36.5 1.0
CB D:HIS249 4.0 38.7 1.0
C18 D:8L7500 4.0 46.4 0.8
CG D:HIS249 4.1 35.5 1.0
C22 D:8L7500 4.1 49.8 0.8
C17 D:8L7500 4.6 46.5 0.8
C25 D:8L7500 4.6 75.8 0.8
C27 D:8L7500 4.7 74.4 0.8
NE2 D:HIS249 4.8 35.3 1.0
C29 D:8L7500 4.8 70.0 0.8

Reference:

N.Maltseva, Y.Kim, R.Mulligan, M.Makowska-Grzyska, M.Gu, D.R.Gollapalli, L.Hedstrom, A.Joachimiak, W.F.Anderson, Center For Structural Genomics Of Infectious Diseases(Csgid). Crystal Structure of Inosine 5'-Monophosphate Dehydrogenase From Clostridium Perfringens Complexed with Imp and P176 To Be Published.
Page generated: Sat Dec 12 12:32:36 2020

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