Chlorine in PDB 5uz8: Crystal Structure of Mouse Cadherin-23 EC22-24

The structure of Crystal Structure of Mouse Cadherin-23 EC22-24, PDB code: 5uz8 was solved by A.Patel, A.Jaiganesh, M.Sotomayor, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 1.85
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	89.537, 57.208, 114.667, 90.00, 112.55, 90.00
R / Rfree (%)	17.1 / 18.8

The structure of Crystal Structure of Mouse Cadherin-23 EC22-24 also contains other interesting chemical elements:

Calcium

(Ca)

7 atoms

The binding sites of Chlorine atom in the Crystal Structure of Mouse Cadherin-23 EC22-24 (pdb code 5uz8). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Crystal Structure of Mouse Cadherin-23 EC22-24, PDB code: 5uz8:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in the Crystal Structure of Mouse Cadherin-23 EC22-24


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Mouse Cadherin-23 EC22-24 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl2601 b:16.8 occ:1.00 ND2 A:ASN2428 3.3 16.2 1.0 ND2 A:ASN2430 3.4 15.2 1.0 OD1 A:ASN2428 4.1 14.4 1.0 CG A:ASN2428 4.2 14.8 1.0 O A:HOH3110 4.4 25.6 1.0 O A:HOH3130 4.5 21.2 1.0 CG A:ASN2430 4.5 14.9 1.0 CB A:ASN2430 4.8 14.2 1.0

Chlorine binding site 2 out of 3 in the Crystal Structure of Mouse Cadherin-23 EC22-24


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Mouse Cadherin-23 EC22-24 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl2602 b:24.6 occ:1.00 O A:HOH3149 2.7 48.1 1.0 O A:HOH3200 3.0 42.5 1.0 O A:HOH3234 3.2 35.9 1.0 N A:PHE2389 3.2 15.9 1.0 CA A:VAL2388 3.8 16.1 1.0 CB A:VAL2388 3.9 16.7 1.0 CD2 A:PHE2389 4.0 20.9 1.0 C A:VAL2388 4.0 15.8 1.0 CB A:PHE2389 4.0 17.4 1.0 CD1 A:ILE2392 4.1 16.1 1.0 CA A:PHE2389 4.1 16.1 1.0 CB A:ILE2392 4.2 16.2 1.0 CG1 A:ILE2392 4.3 16.5 1.0 CG1 A:VAL2388 4.4 17.5 1.0 O A:PHE2389 4.4 15.3 1.0 O A:HOH2728 4.5 42.7 1.0 CG A:PHE2389 4.5 19.4 1.0 O A:HOH2909 4.6 42.2 1.0 C A:PHE2389 4.8 15.4 1.0 CA A:ILE2392 4.8 17.2 1.0

Chlorine binding site 3 out of 3 in the Crystal Structure of Mouse Cadherin-23 EC22-24


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of Mouse Cadherin-23 EC22-24 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl2603 b:19.5 occ:1.00 O A:HOH2746 3.2 25.2 1.0 NH1 A:ARG2475 3.3 17.6 1.0 CB A:HIS2447 3.6 14.3 1.0 O A:ASP2446 3.7 15.1 1.0 CD A:ARG2475 3.8 16.4 1.0 CG A:HIS2447 3.9 14.8 1.0 ND1 A:HIS2447 3.9 15.6 1.0 CG A:ARG2475 4.0 15.5 1.0 CB A:ARG2475 4.1 15.0 1.0 CZ A:ARG2475 4.3 17.9 1.0 CG A:ASP2446 4.3 18.9 1.0 C A:ASP2446 4.4 15.2 1.0 OD1 A:ASP2446 4.4 19.1 1.0 O A:HOH2738 4.5 38.9 1.0 NE A:ARG2475 4.5 17.3 1.0 OD2 A:ASP2446 4.5 20.9 1.0 O A:HOH3162 4.5 33.6 1.0 CA A:ARG2475 4.6 14.5 1.0 CA A:HIS2447 4.7 13.8 1.0 CE1 A:HIS2447 4.8 16.6 1.0 CD2 A:HIS2447 4.8 15.8 1.0 N A:HIS2447 4.8 14.3 1.0 CB A:ASP2446 4.8 16.9 1.0 O A:HOH2998 4.8 17.1 1.0

A.Jaiganesh, P.De-La-Torre, A.A.Patel, D.J.Termine, F.Velez-Cortes, C.Chen, M.Sotomayor. Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness. Structure V. 26 1210 2018.
ISSN: ISSN 1878-4186
PubMed: 30033219
DOI: 10.1016/J.STR.2018.06.003