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Chlorine in PDB 5vcr: Alpha-1,6-Mannosyl-Glycoprotein 2-Beta-N-Acetylglucosaminyltransferase with Bound Uranium Dioxide

Enzymatic activity of Alpha-1,6-Mannosyl-Glycoprotein 2-Beta-N-Acetylglucosaminyltransferase with Bound Uranium Dioxide

All present enzymatic activity of Alpha-1,6-Mannosyl-Glycoprotein 2-Beta-N-Acetylglucosaminyltransferase with Bound Uranium Dioxide:
2.4.1.143;

Protein crystallography data

The structure of Alpha-1,6-Mannosyl-Glycoprotein 2-Beta-N-Acetylglucosaminyltransferase with Bound Uranium Dioxide, PDB code: 5vcr was solved by J.H.Sanders, R.Kadirvelraj, Z.A.Wood, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 56.40 / 1.99
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 105.670, 105.670, 171.950, 90.00, 90.00, 90.00
R / Rfree (%) 17.7 / 20.8

Other elements in 5vcr:

The structure of Alpha-1,6-Mannosyl-Glycoprotein 2-Beta-N-Acetylglucosaminyltransferase with Bound Uranium Dioxide also contains other interesting chemical elements:

Uranium (U) 4 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Alpha-1,6-Mannosyl-Glycoprotein 2-Beta-N-Acetylglucosaminyltransferase with Bound Uranium Dioxide (pdb code 5vcr). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Alpha-1,6-Mannosyl-Glycoprotein 2-Beta-N-Acetylglucosaminyltransferase with Bound Uranium Dioxide, PDB code: 5vcr:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in 5vcr

Go back to Chlorine Binding Sites List in 5vcr
Chlorine binding site 1 out of 2 in the Alpha-1,6-Mannosyl-Glycoprotein 2-Beta-N-Acetylglucosaminyltransferase with Bound Uranium Dioxide


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Alpha-1,6-Mannosyl-Glycoprotein 2-Beta-N-Acetylglucosaminyltransferase with Bound Uranium Dioxide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl504

b:51.9
occ:0.50
U A:IUM501 3.5 46.3 0.8
OD2 A:ASP261 3.5 47.0 1.0
NE2 A:HIS374 3.7 58.4 1.0
O2 A:IUM501 3.9 0.8 0.8
O1 A:IUM501 3.9 0.1 0.8
CE1 A:HIS374 4.2 57.9 1.0
NH1 A:ARG127 4.2 55.5 1.0
CG A:ASP261 4.7 40.1 1.0
NH2 A:ARG127 4.9 59.0 1.0
CD2 A:HIS374 4.9 50.9 1.0
CZ A:ARG127 5.0 63.6 1.0

Chlorine binding site 2 out of 2 in 5vcr

Go back to Chlorine Binding Sites List in 5vcr
Chlorine binding site 2 out of 2 in the Alpha-1,6-Mannosyl-Glycoprotein 2-Beta-N-Acetylglucosaminyltransferase with Bound Uranium Dioxide


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Alpha-1,6-Mannosyl-Glycoprotein 2-Beta-N-Acetylglucosaminyltransferase with Bound Uranium Dioxide within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl504

b:60.0
occ:0.40
O2 B:IUM502 2.8 48.6 0.4
U B:IUM502 3.8 25.1 0.4
O1 B:IUM502 4.4 40.0 0.4
NE2 B:HIS374 4.5 56.9 1.0
OD2 B:ASP261 4.6 39.9 1.0
NH1 B:ARG127 4.8 61.7 1.0

Reference:

R.Kadirvelraj, J.Y.Yang, J.H.Sanders, L.Liu, A.Ramiah, P.K.Prabhakar, G.J.Boons, Z.A.Wood, K.W.Moremen. Humann-Acetylglucosaminyltransferase II Substrate Recognition Uses A Modular Architecture That Includes A Convergent Exosite. Proc. Natl. Acad. Sci. V. 115 4637 2018U.S.A..
ISSN: ESSN 1091-6490
PubMed: 29666272
DOI: 10.1073/PNAS.1716988115
Page generated: Wed Oct 28 13:06:19 2020

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