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Chlorine in PDB 5vqt: Crystal Structure of Hiv-1 Reverse Transcriptase in Complex with 2- Chloro-N-(6-Cyano-3-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl) Ethoxy)Phenoxy)-4-Methylnaphthalen-1-Yl)-N-Methylacetamide (JLJ686), A Non-Nucleoside InhibitorEnzymatic activity of Crystal Structure of Hiv-1 Reverse Transcriptase in Complex with 2- Chloro-N-(6-Cyano-3-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl) Ethoxy)Phenoxy)-4-Methylnaphthalen-1-Yl)-N-Methylacetamide (JLJ686), A Non-Nucleoside Inhibitor
All present enzymatic activity of Crystal Structure of Hiv-1 Reverse Transcriptase in Complex with 2- Chloro-N-(6-Cyano-3-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl) Ethoxy)Phenoxy)-4-Methylnaphthalen-1-Yl)-N-Methylacetamide (JLJ686), A Non-Nucleoside Inhibitor:
2.7.7.49; 2.7.7.7; 3.1.26.13; Protein crystallography data
The structure of Crystal Structure of Hiv-1 Reverse Transcriptase in Complex with 2- Chloro-N-(6-Cyano-3-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl) Ethoxy)Phenoxy)-4-Methylnaphthalen-1-Yl)-N-Methylacetamide (JLJ686), A Non-Nucleoside Inhibitor, PDB code: 5vqt
was solved by
A.H.Chan,
D.J.Czyzyk,
K.S.Anderson,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Hiv-1 Reverse Transcriptase in Complex with 2- Chloro-N-(6-Cyano-3-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl) Ethoxy)Phenoxy)-4-Methylnaphthalen-1-Yl)-N-Methylacetamide (JLJ686), A Non-Nucleoside Inhibitor
(pdb code 5vqt). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Hiv-1 Reverse Transcriptase in Complex with 2- Chloro-N-(6-Cyano-3-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl) Ethoxy)Phenoxy)-4-Methylnaphthalen-1-Yl)-N-Methylacetamide (JLJ686), A Non-Nucleoside Inhibitor, PDB code: 5vqt: Chlorine binding site 1 out of 1 in 5vqtGo back to Chlorine Binding Sites List in 5vqt
Chlorine binding site 1 out
of 1 in the Crystal Structure of Hiv-1 Reverse Transcriptase in Complex with 2- Chloro-N-(6-Cyano-3-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl) Ethoxy)Phenoxy)-4-Methylnaphthalen-1-Yl)-N-Methylacetamide (JLJ686), A Non-Nucleoside Inhibitor
Mono view Stereo pair view
Reference:
A.H.Chan,
W.G.Lee,
K.A.Spasov,
J.A.Cisneros,
S.N.Kudalkar,
Z.O.Petrova,
A.B.Buckingham,
K.S.Anderson,
W.L.Jorgensen.
Covalent Inhibitors For Eradication of Drug-Resistant Hiv-1 Reverse Transcriptase: From Design to Protein Crystallography. Proc. Natl. Acad. Sci. V. 114 9725 2017U.S.A..
Page generated: Sat Dec 12 12:34:58 2020
ISSN: ESSN 1091-6490 PubMed: 28827354 DOI: 10.1073/PNAS.1711463114 |
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