Chlorine in PDB 5vry: Human Dna Polymerase Beta 8-Oxog:Dc Extension with Dttp After 20 S

Enzymatic activity of Human Dna Polymerase Beta 8-Oxog:Dc Extension with Dttp After 20 S

All present enzymatic activity of Human Dna Polymerase Beta 8-Oxog:Dc Extension with Dttp After 20 S:
2.7.7.7;

Protein crystallography data

The structure of Human Dna Polymerase Beta 8-Oxog:Dc Extension with Dttp After 20 S, PDB code: 5vry was solved by A.J.Reed, Z.Suo, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	48.62 / 1.90
*Space group*	P 1 2₁ 1
*Cell size a, b, c (Å), α, β, γ (°)*	50.900, 80.100, 55.600, 90.00, 107.20, 90.00
*R / R_free (%)*	20.3 / 24.4

Other elements in 5vry:

The structure of Human Dna Polymerase Beta 8-Oxog:Dc Extension with Dttp After 20 S also contains other interesting chemical elements:

Magnesium

(Mg)

6 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Human Dna Polymerase Beta 8-Oxog:Dc Extension with Dttp After 20 S (pdb code 5vry). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Human Dna Polymerase Beta 8-Oxog:Dc Extension with Dttp After 20 S, PDB code: 5vry:

Chlorine binding site 1 out of 1 in 5vry

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Chlorine Binding Sites List in 5vry

Chlorine binding site 1 out of 1 in the Human Dna Polymerase Beta 8-Oxog:Dc Extension with Dttp After 20 S

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human Dna Polymerase Beta 8-Oxog:Dc Extension with Dttp After 20 S within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Cl402 b:58.6 occ:1.00	O	A:HOH597	3.2	36.7	1.0
	O	A:HOH517	3.5	21.7	1.0
	OE1	A:GLU232	3.6	35.3	1.0
	CG2	A:THR205	3.9	43.0	1.0
	O	A:GLU232	4.0	23.1	1.0
	CB	A:GLU232	4.1	27.1	1.0
	CD2	A:LEU259	4.3	19.7	1.0
	OG1	A:THR205	4.4	41.1	1.0
	CE1	A:PHE200	4.4	23.4	1.0
	CG2	A:THR233	4.5	21.8	1.0
	CD1	A:PHE200	4.6	23.5	1.0
	CD	A:GLU232	4.6	32.1	1.0
	C	A:GLU232	4.6	23.5	1.0
	CZ	A:PHE200	4.7	23.3	1.0
	O	A:HOH518	4.7	42.1	1.0
	CG	A:GLU232	4.8	29.8	1.0
	O	A:HOH718	4.8	52.8	1.0
	CB	A:THR205	4.8	42.6	1.0
	CA	A:GLU232	4.9	25.0	1.0
	CG	A:PHE200	5.0	23.1	1.0

Reference:

A.J.Reed, Z.Suo. Time-Dependent Extension From An 8-Oxoguanine Lesion By Human Dna Polymerase Beta. J. Am. Chem. Soc. V. 139 9684 2017.
ISSN: ESSN 1520-5126
PubMed: 28682600
DOI: 10.1021/JACS.7B05048

Page generated: Fri Jul 26 19:01:02 2024

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