Chlorine in PDB 5vxz: High-Affinity Axl Decoy Receptor

All present enzymatic activity of High-Affinity Axl Decoy Receptor:
2.7.10.1;

The structure of High-Affinity Axl Decoy Receptor, PDB code: 5vxz was solved by I.I.Mathrews, S.Kapur, M.S.Kariolis, J.R.Cochran, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	38.61 / 2.30
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	77.220, 80.470, 249.650, 90.00, 90.00, 90.00
R / Rfree (%)	19.8 / 24.7

The structure of High-Affinity Axl Decoy Receptor also contains other interesting chemical elements:

Calcium

(Ca)

2 atoms

The binding sites of Chlorine atom in the High-Affinity Axl Decoy Receptor (pdb code 5vxz). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the High-Affinity Axl Decoy Receptor, PDB code: 5vxz:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in the High-Affinity Axl Decoy Receptor


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of High-Affinity Axl Decoy Receptor within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl704 b:0.2 occ:1.00 N A:VAL292 3.6 82.0 1.0 CB A:SER291 3.8 76.6 1.0 CG2 A:VAL292 4.0 93.3 1.0 CA A:SER291 4.0 74.9 1.0 N A:LYS293 4.0 80.4 1.0 C A:SER291 4.2 76.6 1.0 CB A:LYS293 4.4 84.2 1.0 CA A:VAL292 4.6 82.4 1.0 OG A:SER291 4.6 78.8 1.0 CG A:LYS293 4.8 88.3 1.0 CA A:LYS293 4.8 78.6 1.0 CB A:VAL292 4.8 88.3 1.0 C A:VAL292 4.9 79.2 1.0 CD A:LYS293 4.9 90.7 1.0

Chlorine binding site 2 out of 3 in the High-Affinity Axl Decoy Receptor


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of High-Affinity Axl Decoy Receptor within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl704 b:57.7 occ:0.50 CL B:CL704 0.0 57.7 0.5 CL B:CL704 2.1 65.2 0.5 O B:HOH892 3.4 48.9 1.0 CB B:SER291 3.8 50.4 1.0 N B:VAL292 3.9 47.4 1.0 N B:LYS293 3.9 44.8 1.0 CA B:SER291 3.9 48.2 1.0 C B:SER291 4.1 47.3 1.0 CB B:LYS293 4.2 46.7 1.0 CG2 B:VAL292 4.2 60.9 1.0 OG B:SER291 4.2 58.2 1.0 CG B:LYS293 4.5 52.9 1.0 CA B:LYS293 4.6 43.5 1.0 CA B:VAL292 4.7 48.7 1.0 C B:VAL292 4.8 45.4 1.0 CD B:LYS293 5.0 57.6 1.0

Chlorine binding site 3 out of 3 in the High-Affinity Axl Decoy Receptor


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of High-Affinity Axl Decoy Receptor within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl704 b:65.2 occ:0.50 CL B:CL704 0.0 65.2 0.5 CL B:CL704 2.1 57.7 0.5 O B:HOH892 3.3 48.9 1.0 N B:VAL292 3.3 47.4 1.0 CG2 B:VAL292 3.5 60.9 1.0 CA B:SER291 3.6 48.2 1.0 C B:SER291 4.0 47.3 1.0 O B:LYS290 4.1 46.9 1.0 CB B:SER291 4.3 50.4 1.0 CA B:VAL292 4.3 48.7 1.0 CB B:VAL292 4.3 56.8 1.0 N B:LYS293 4.6 44.8 1.0 OG B:SER291 4.6 58.2 1.0 CG1 B:VAL292 4.6 56.2 1.0 N B:SER291 4.7 46.3 1.0 C B:LYS290 4.8 47.0 1.0

M.S.Kariolis, Y.R.Miao, A.Diep, S.E.Nash, M.M.Olcina, D.Jiang, D.S.Jones, S.Kapur, I.I.Mathews, A.C.Koong, E.B.Rankin, J.R.Cochran, A.J.Giaccia. Inhibition of the GAS6/Axl Pathway Augments the Efficacy of Chemotherapies. J. Clin. Invest. V. 127 183 2017.
ISSN: ISSN 1558-8238
PubMed: 27893463
DOI: 10.1172/JCI85610