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Chlorine in PDB 5wal: Identification of An Imidazopyridine Scaffold to Generate Potent and Selective TYK2 Inhibitors That Demonstrate Activity in An in Vivo Psoriasis Model
Enzymatic activity of Identification of An Imidazopyridine Scaffold to Generate Potent and Selective TYK2 Inhibitors That Demonstrate Activity in An in Vivo Psoriasis Model
All present enzymatic activity of Identification of An Imidazopyridine Scaffold to Generate Potent and Selective TYK2 Inhibitors That Demonstrate Activity in An in Vivo Psoriasis Model:
2.7.10.2;
2.7.10.2;
Protein crystallography data
The structure of Identification of An Imidazopyridine Scaffold to Generate Potent and Selective TYK2 Inhibitors That Demonstrate Activity in An in Vivo Psoriasis Model, PDB code: 5wal
was solved by
M.H.Ultsch,
S.Magnuson,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 60.93 / 2.45 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 36.097, 74.301, 106.444, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 18.2 / 24.3 |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Identification of An Imidazopyridine Scaffold to Generate Potent and Selective TYK2 Inhibitors That Demonstrate Activity in An in Vivo Psoriasis Model
(pdb code 5wal). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Identification of An Imidazopyridine Scaffold to Generate Potent and Selective TYK2 Inhibitors That Demonstrate Activity in An in Vivo Psoriasis Model, PDB code: 5wal:
Jump to Chlorine binding site number: 1; 2;
In total 2 binding sites of Chlorine where determined in the Identification of An Imidazopyridine Scaffold to Generate Potent and Selective TYK2 Inhibitors That Demonstrate Activity in An in Vivo Psoriasis Model, PDB code: 5wal:
Jump to Chlorine binding site number: 1; 2;
Chlorine binding site 1 out of 2 in 5wal
Go back to
Chlorine Binding Sites List in 5wal
Chlorine binding site 1 out
of 2 in the Identification of An Imidazopyridine Scaffold to Generate Potent and Selective TYK2 Inhibitors That Demonstrate Activity in An in Vivo Psoriasis Model
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Identification of An Imidazopyridine Scaffold to Generate Potent and Selective TYK2 Inhibitors That Demonstrate Activity in An in Vivo Psoriasis Model within 5.0Å range:
|
Chlorine binding site 2 out of 2 in 5wal
Go back to
Chlorine Binding Sites List in 5wal
Chlorine binding site 2 out
of 2 in the Identification of An Imidazopyridine Scaffold to Generate Potent and Selective TYK2 Inhibitors That Demonstrate Activity in An in Vivo Psoriasis Model
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Identification of An Imidazopyridine Scaffold to Generate Potent and Selective TYK2 Inhibitors That Demonstrate Activity in An in Vivo Psoriasis Model within 5.0Å range:
|
Reference:
J.Liang,
A.Van Abbema,
M.Balazs,
K.Barrett,
L.Berezhkovsky,
W.S.Blair,
C.Chang,
D.Delarosa,
J.Devoss,
J.Driscoll,
C.Eigenbrot,
S.Goodacre,
N.Ghilardi,
C.Macleod,
A.Johnson,
P.Bir Kohli,
Y.Lai,
Z.Lin,
P.Mantik,
K.Menghrajani,
H.Nguyen,
I.Peng,
A.Sambrone,
S.Shia,
J.Smith,
S.Sohn,
V.Tsui,
M.Ultsch,
K.Williams,
L.C.Wu,
W.Yang,
B.Zhang,
S.Magnuson.
Identification of An Imidazopyridine Scaffold to Generate Potent and Selective TYK2 Inhibitors That Demonstrate Activity in An in Vivo Psoriasis Model. Bioorg. Med. Chem. Lett. V. 27 4370 2017.
ISSN: ESSN 1464-3405
PubMed: 28830649
DOI: 10.1016/J.BMCL.2017.08.022
Page generated: Fri Jul 26 19:16:53 2024
ISSN: ESSN 1464-3405
PubMed: 28830649
DOI: 10.1016/J.BMCL.2017.08.022
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