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Chlorine in PDB 5wal: Identification of An Imidazopyridine Scaffold to Generate Potent and Selective TYK2 Inhibitors That Demonstrate Activity in An in Vivo Psoriasis ModelEnzymatic activity of Identification of An Imidazopyridine Scaffold to Generate Potent and Selective TYK2 Inhibitors That Demonstrate Activity in An in Vivo Psoriasis Model
All present enzymatic activity of Identification of An Imidazopyridine Scaffold to Generate Potent and Selective TYK2 Inhibitors That Demonstrate Activity in An in Vivo Psoriasis Model:
2.7.10.2; Protein crystallography data
The structure of Identification of An Imidazopyridine Scaffold to Generate Potent and Selective TYK2 Inhibitors That Demonstrate Activity in An in Vivo Psoriasis Model, PDB code: 5wal
was solved by
M.H.Ultsch,
S.Magnuson,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Identification of An Imidazopyridine Scaffold to Generate Potent and Selective TYK2 Inhibitors That Demonstrate Activity in An in Vivo Psoriasis Model
(pdb code 5wal). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Identification of An Imidazopyridine Scaffold to Generate Potent and Selective TYK2 Inhibitors That Demonstrate Activity in An in Vivo Psoriasis Model, PDB code: 5wal: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 5walGo back to Chlorine Binding Sites List in 5wal
Chlorine binding site 1 out
of 2 in the Identification of An Imidazopyridine Scaffold to Generate Potent and Selective TYK2 Inhibitors That Demonstrate Activity in An in Vivo Psoriasis Model
Mono view Stereo pair view
Chlorine binding site 2 out of 2 in 5walGo back to Chlorine Binding Sites List in 5wal
Chlorine binding site 2 out
of 2 in the Identification of An Imidazopyridine Scaffold to Generate Potent and Selective TYK2 Inhibitors That Demonstrate Activity in An in Vivo Psoriasis Model
Mono view Stereo pair view
Reference:
J.Liang,
A.Van Abbema,
M.Balazs,
K.Barrett,
L.Berezhkovsky,
W.S.Blair,
C.Chang,
D.Delarosa,
J.Devoss,
J.Driscoll,
C.Eigenbrot,
S.Goodacre,
N.Ghilardi,
C.Macleod,
A.Johnson,
P.Bir Kohli,
Y.Lai,
Z.Lin,
P.Mantik,
K.Menghrajani,
H.Nguyen,
I.Peng,
A.Sambrone,
S.Shia,
J.Smith,
S.Sohn,
V.Tsui,
M.Ultsch,
K.Williams,
L.C.Wu,
W.Yang,
B.Zhang,
S.Magnuson.
Identification of An Imidazopyridine Scaffold to Generate Potent and Selective TYK2 Inhibitors That Demonstrate Activity in An in Vivo Psoriasis Model. Bioorg. Med. Chem. Lett. V. 27 4370 2017.
Page generated: Sat Dec 12 12:36:11 2020
ISSN: ESSN 1464-3405 PubMed: 28830649 DOI: 10.1016/J.BMCL.2017.08.022 |
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