Chlorine in PDB 5wfo: Ligand-Bound Ras:Sos:Ras Complex

The structure of Ligand-Bound Ras:Sos:Ras Complex, PDB code: 5wfo was solved by Q.Sun, J.Phan, M.C.Burns, S.W.Fesik, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.46 / 1.99
Space group	I 4 2 2
Cell size a, b, c (Å), α, β, γ (°)	182.735, 182.735, 177.866, 90.00, 90.00, 90.00
R / Rfree (%)	16.9 / 18.8

The structure of Ligand-Bound Ras:Sos:Ras Complex also contains other interesting chemical elements:

Fluorine	(F)	1 atom
Magnesium	(Mg)	1 atom

The binding sites of Chlorine atom in the Ligand-Bound Ras:Sos:Ras Complex (pdb code 5wfo). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Ligand-Bound Ras:Sos:Ras Complex, PDB code: 5wfo:

Chlorine binding site 1 out of 1 in the Ligand-Bound Ras:Sos:Ras Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Ligand-Bound Ras:Sos:Ras Complex within 5.0Å range: probe atom residue distance (Å) B Occ N:Cl1101 b:32.5 occ:1.00 CL14 N:5UU1101 0.0 32.5 1.0 C11 N:5UU1101 1.7 29.1 1.0 C12 N:5UU1101 2.7 21.1 1.0 C08 N:5UU1101 2.7 28.1 1.0 CG1 N:VAL883 3.6 15.6 1.0 O N:VAL883 3.8 16.6 1.0 C09 N:5UU1101 4.0 30.2 1.0 C04 N:5UU1101 4.0 29.4 1.0 CG2 N:VAL852 4.2 13.2 1.0 CG2 N:THR889 4.4 18.4 1.0 CG1 N:VAL852 4.4 13.5 1.0 C02 N:5UU1101 4.5 31.5 1.0 SD N:MET878 4.5 19.6 1.0 CB N:THR889 4.5 16.1 1.0 CB N:LEU886 4.6 16.7 1.0 O N:LEU886 4.6 19.9 1.0 C N:VAL883 4.6 17.8 1.0 N N:PHE890 4.6 17.9 1.0 CB N:PHE890 4.7 23.0 1.0 CA N:PHE890 4.7 22.8 1.0 CB N:VAL852 4.9 14.2 1.0 CB N:VAL883 5.0 14.3 1.0 CD1 N:LEU886 5.0 15.4 1.0

M.C.Burns, J.E.Howes, Q.Sun, A.J.Little, D.V.Camper, J.R.Abbott, J.Phan, T.Lee, A.G.Waterson, O.W.Rossanese, S.W.Fesik. High-Throughput Screening Identifies Small Molecules That Bind to the Ras:Sos:Ras Complex and Perturb Ras Signaling. Anal. Biochem. V. 548 44 2018.
ISSN: ISSN 1096-0309
PubMed: 29444450
DOI: 10.1016/J.AB.2018.01.025