Chlorine in PDB 5wfo: Ligand-Bound Ras:Sos:Ras Complex

Protein crystallography data

The structure of Ligand-Bound Ras:Sos:Ras Complex, PDB code: 5wfo was solved by Q.Sun, J.Phan, M.C.Burns, S.W.Fesik, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 48.46 / 1.99
Space group I 4 2 2
Cell size a, b, c (Å), α, β, γ (°) 182.735, 182.735, 177.866, 90.00, 90.00, 90.00
R / Rfree (%) 16.9 / 18.8

Other elements in 5wfo:

The structure of Ligand-Bound Ras:Sos:Ras Complex also contains other interesting chemical elements:

Fluorine (F) 1 atom
Magnesium (Mg) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Ligand-Bound Ras:Sos:Ras Complex (pdb code 5wfo). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Ligand-Bound Ras:Sos:Ras Complex, PDB code: 5wfo:

Chlorine binding site 1 out of 1 in 5wfo

Go back to Chlorine Binding Sites List in 5wfo
Chlorine binding site 1 out of 1 in the Ligand-Bound Ras:Sos:Ras Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Ligand-Bound Ras:Sos:Ras Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
N:Cl1101

b:32.5
occ:1.00
CL14 N:5UU1101 0.0 32.5 1.0
C11 N:5UU1101 1.7 29.1 1.0
C12 N:5UU1101 2.7 21.1 1.0
C08 N:5UU1101 2.7 28.1 1.0
CG1 N:VAL883 3.6 15.6 1.0
O N:VAL883 3.8 16.6 1.0
C09 N:5UU1101 4.0 30.2 1.0
C04 N:5UU1101 4.0 29.4 1.0
CG2 N:VAL852 4.2 13.2 1.0
CG2 N:THR889 4.4 18.4 1.0
CG1 N:VAL852 4.4 13.5 1.0
C02 N:5UU1101 4.5 31.5 1.0
SD N:MET878 4.5 19.6 1.0
CB N:THR889 4.5 16.1 1.0
CB N:LEU886 4.6 16.7 1.0
O N:LEU886 4.6 19.9 1.0
C N:VAL883 4.6 17.8 1.0
N N:PHE890 4.6 17.9 1.0
CB N:PHE890 4.7 23.0 1.0
CA N:PHE890 4.7 22.8 1.0
CB N:VAL852 4.9 14.2 1.0
CB N:VAL883 5.0 14.3 1.0
CD1 N:LEU886 5.0 15.4 1.0

Reference:

M.C.Burns, J.E.Howes, Q.Sun, A.J.Little, D.V.Camper, J.R.Abbott, J.Phan, T.Lee, A.G.Waterson, O.W.Rossanese, S.W.Fesik. High-Throughput Screening Identifies Small Molecules That Bind to the Ras:Sos:Ras Complex and Perturb Ras Signaling. Anal. Biochem. V. 548 44 2018.
ISSN: ISSN 1096-0309
PubMed: 29444450
DOI: 10.1016/J.AB.2018.01.025
Page generated: Sat Dec 12 12:36:27 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy