Chlorine in PDB 5x28: Crystal Structure of Egfr 696-1022 L858R in Complex with Sklb(6)

All present enzymatic activity of Crystal Structure of Egfr 696-1022 L858R in Complex with Sklb(6):
2.7.10.1;

The structure of Crystal Structure of Egfr 696-1022 L858R in Complex with Sklb(6), PDB code: 5x28 was solved by C.H.Yun, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	31.02 / 2.95
Space group	I 2 3
Cell size a, b, c (Å), α, β, γ (°)	145.513, 145.513, 145.513, 90.00, 90.00, 90.00
R / Rfree (%)	20.9 / 25

The binding sites of Chlorine atom in the Crystal Structure of Egfr 696-1022 L858R in Complex with Sklb(6) (pdb code 5x28). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Egfr 696-1022 L858R in Complex with Sklb(6), PDB code: 5x28:

Chlorine binding site 1 out of 1 in the Crystal Structure of Egfr 696-1022 L858R in Complex with Sklb(6)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Egfr 696-1022 L858R in Complex with Sklb(6) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1102 b:82.4 occ:1.00 N A:ILE878 3.5 82.4 1.0 CA A:PRO877 3.8 85.5 1.0 N A:LYS879 3.9 76.1 1.0 C A:PRO877 4.0 83.3 1.0 CZ3 A:TRP880 4.0 64.3 1.0 CD A:LYS879 4.1 76.7 1.0 O A:VAL876 4.1 87.5 1.0 CG A:LYS879 4.3 72.0 1.0 CB A:LYS879 4.3 72.1 1.0 CE3 A:TRP880 4.4 61.8 1.0 CA A:ILE878 4.5 83.8 1.0 CB A:ILE878 4.6 84.3 1.0 CB A:PRO877 4.7 76.4 1.0 C A:ILE878 4.7 76.7 1.0 CE A:LYS879 4.7 76.5 1.0 CA A:LYS879 4.8 70.5 1.0 N A:PRO877 4.9 90.2 1.0 C A:VAL876 4.9 86.5 1.0

S.J.Zhu, P.Zhao, J.Yang, R.Ma, X.E.Yan, S.Y.Yang, J.W.Yang, C.H.Yun. Structural Insights Into Drug Development Strategy Targeting Egfr T790M/C797S. Oncotarget V. 9 13652 2018.
ISSN: ESSN 1949-2553
PubMed: 29568384
DOI: 10.18632/ONCOTARGET.24113