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Chlorine in PDB 5xs2: CDK8-Cycc in Complex with Compound 17:3-Chloro-4-(4-Pyridyl)-1H- Pyrrole-2-CarboxamideEnzymatic activity of CDK8-Cycc in Complex with Compound 17:3-Chloro-4-(4-Pyridyl)-1H- Pyrrole-2-Carboxamide
All present enzymatic activity of CDK8-Cycc in Complex with Compound 17:3-Chloro-4-(4-Pyridyl)-1H- Pyrrole-2-Carboxamide:
2.7.11.22; 2.7.11.23; Protein crystallography data
The structure of CDK8-Cycc in Complex with Compound 17:3-Chloro-4-(4-Pyridyl)-1H- Pyrrole-2-Carboxamide, PDB code: 5xs2
was solved by
Z.Zhou,
Z.Xu,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the CDK8-Cycc in Complex with Compound 17:3-Chloro-4-(4-Pyridyl)-1H- Pyrrole-2-Carboxamide
(pdb code 5xs2). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the CDK8-Cycc in Complex with Compound 17:3-Chloro-4-(4-Pyridyl)-1H- Pyrrole-2-Carboxamide, PDB code: 5xs2: Chlorine binding site 1 out of 1 in 5xs2Go back to Chlorine Binding Sites List in 5xs2
Chlorine binding site 1 out
of 1 in the CDK8-Cycc in Complex with Compound 17:3-Chloro-4-(4-Pyridyl)-1H- Pyrrole-2-Carboxamide
Mono view Stereo pair view
Reference:
X.Han,
M.Jiang,
C.Zhou,
Z.Zhou,
Z.Xu,
L.Wang,
A.V.Mayweg,
R.Niu,
T.G.Jin,
S.Yang.
Discovery of Potent and Selective CDK8 Inhibitors Through Fbdd Approach Bioorg. Med. Chem. Lett. V. 27 4488 2017.
Page generated: Sat Dec 12 12:39:34 2020
ISSN: ESSN 1464-3405 PubMed: 28802632 DOI: 10.1016/J.BMCL.2017.07.080 |
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