Chlorine in PDB 5z30: The Crystal Structure of the Nucleosome Containing A Cancer-Associated Histone H2A.Z R80C Mutant

The structure of The Crystal Structure of the Nucleosome Containing A Cancer-Associated Histone H2A.Z R80C Mutant, PDB code: 5z30 was solved by N.Horikoshi, Y.Arimura, H.Kurumizaka, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.70 / 2.45
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	99.399, 108.332, 170.902, 90.00, 90.00, 90.00
R / Rfree (%)	20.2 / 24.4

The structure of The Crystal Structure of the Nucleosome Containing A Cancer-Associated Histone H2A.Z R80C Mutant also contains other interesting chemical elements:

Manganese

(Mn)

11 atoms

The binding sites of Chlorine atom in the The Crystal Structure of the Nucleosome Containing A Cancer-Associated Histone H2A.Z R80C Mutant (pdb code 5z30). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the The Crystal Structure of the Nucleosome Containing A Cancer-Associated Histone H2A.Z R80C Mutant, PDB code: 5z30:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the The Crystal Structure of the Nucleosome Containing A Cancer-Associated Histone H2A.Z R80C Mutant


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of The Crystal Structure of the Nucleosome Containing A Cancer-Associated Histone H2A.Z R80C Mutant within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl301 b:59.1 occ:1.00 N A:LYS122 3.3 49.3 1.0 CD A:PRO121 3.4 47.8 1.0 N A:PRO121 3.6 51.5 1.0 CB A:PRO121 3.7 50.0 1.0 CG A:LYS122 3.7 50.5 1.0 CG A:PRO121 3.9 48.4 1.0 CB A:MET120 3.9 49.2 1.0 CB A:LYS122 3.9 43.1 1.0 CA A:PRO121 4.0 45.2 1.0 C A:PRO121 4.0 49.1 1.0 CA A:LYS122 4.2 47.2 1.0 CD A:LYS122 4.2 54.4 1.0 C A:MET120 4.3 50.4 1.0 CE A:LYS122 4.3 62.6 1.0 CA A:MET120 4.6 47.8 1.0 CG A:MET120 4.9 49.9 1.0

Chlorine binding site 2 out of 2 in the The Crystal Structure of the Nucleosome Containing A Cancer-Associated Histone H2A.Z R80C Mutant


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of The Crystal Structure of the Nucleosome Containing A Cancer-Associated Histone H2A.Z R80C Mutant within 5.0Å range: probe atom residue distance (Å) B Occ E:Cl302 b:59.9 occ:1.00 N E:LYS122 3.0 38.0 1.0 CG E:LYS122 3.4 38.9 1.0 CB E:LYS122 3.5 33.8 1.0 CD E:PRO121 3.5 41.0 1.0 N E:PRO121 3.6 43.0 1.0 CB E:PRO121 3.7 44.6 1.0 CA E:LYS122 3.8 43.7 1.0 CB E:MET120 3.8 42.7 1.0 C E:PRO121 3.9 38.7 1.0 CD E:LYS122 3.9 42.7 1.0 CA E:PRO121 4.0 42.4 1.0 CG E:PRO121 4.0 44.0 1.0 C E:MET120 4.2 40.7 1.0 CE E:LYS122 4.2 59.9 1.0 CA E:MET120 4.6 41.3 1.0 CG E:MET120 4.9 40.2 1.0 SD E:MET120 4.9 55.4 1.0 O E:MET120 4.9 40.6 1.0

Y.Arimura, M.Ikura, R.Fujita, M.Noda, W.Kobayashi, N.Horikoshi, J.Sun, L.Shi, M.Kusakabe, M.Harata, Y.Ohkawa, S.Tashiro, H.Kimura, T.Ikura, H.Kurumizaka. Cancer-Associated Mutations of Histones H2B, H3.1 and H2A.Z.1 Affect the Structure and Stability of the Nucleosome. Nucleic Acids Res. V. 46 10007 2018.
ISSN: ESSN 1362-4962
PubMed: 30053102
DOI: 10.1093/NAR/GKY661