Chlorine in PDB 5z5o: Structure of Pycnonodysostosis Disease Related I249T Mutant of Human Cathepsin K

Enzymatic activity of Structure of Pycnonodysostosis Disease Related I249T Mutant of Human Cathepsin K

All present enzymatic activity of Structure of Pycnonodysostosis Disease Related I249T Mutant of Human Cathepsin K:
3.4.22.38;

Protein crystallography data

The structure of Structure of Pycnonodysostosis Disease Related I249T Mutant of Human Cathepsin K, PDB code: 5z5o was solved by S.Biswas, S.Roy, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 52.22 / 1.92
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 50.100, 67.270, 82.870, 90.00, 91.83, 90.00
R / Rfree (%) 16.2 / 20.4

Other elements in 5z5o:

The structure of Structure of Pycnonodysostosis Disease Related I249T Mutant of Human Cathepsin K also contains other interesting chemical elements:

Sodium (Na) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Structure of Pycnonodysostosis Disease Related I249T Mutant of Human Cathepsin K (pdb code 5z5o). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Structure of Pycnonodysostosis Disease Related I249T Mutant of Human Cathepsin K, PDB code: 5z5o:

Chlorine binding site 1 out of 1 in 5z5o

Go back to Chlorine Binding Sites List in 5z5o
Chlorine binding site 1 out of 1 in the Structure of Pycnonodysostosis Disease Related I249T Mutant of Human Cathepsin K


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of Pycnonodysostosis Disease Related I249T Mutant of Human Cathepsin K within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl428

b:84.2
occ:1.00
 N A:LEU144 3.1 32.8 1.0
NZ A:LYS143 3.1 0.3 1.0
CD A:LYS143 3.5 0.4 1.0
CA A:LYS143 3.7 44.4 1.0
O A:HOH526 3.8 39.7 1.0
CB A:LEU144 3.8 36.2 1.0
CE A:LYS143 3.8 0.3 1.0
C A:LYS143 3.9 43.8 1.0
O A:GLY142 3.9 46.5 1.0
CA A:LEU144 4.0 37.0 1.0
O A:LEU144 4.0 41.2 1.0
CG A:LYS143 4.1 0.4 1.0
C A:LEU144 4.4 32.2 1.0
NZ A:LYS138 4.5 40.2 1.0
CB A:LYS143 4.5 49.3 1.0
N A:LYS143 4.7 35.4 1.0
C A:GLY142 4.8 48.8 1.0

Reference:

S.Roy, S.Das Chakraborty, S.Biswas. Not All Pycnodysostosis-Related Mutants of Human Cathepsin K Are Inactive - Crystal Structure and Biochemical Studies of An Active Mutant I249T. Febs J. V. 285 4265 2018.
ISSN: ISSN 1742-4658
PubMed: 30199612
DOI: 10.1111/FEBS.14655
Page generated: Sat Dec 12 12:41:48 2020

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