Chlorine in PDB 5zk7: Stapled-Peptides Tailored Against Initiation of Translation

The structure of Stapled-Peptides Tailored Against Initiation of Translation, PDB code: 5zk7 was solved by D.Lama, A.Liberator, Y.Frosi, J.Nakhle, N.Tsomia, T.Bashir, D.P.Lane, C.J.Brown, C.S.Verma, S.Auvin, F.Ciesielski, M.Uhring, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.89 / 2.12
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	57.350, 68.170, 111.010, 90.00, 90.00, 90.00
R / Rfree (%)	21.6 / 27

The structure of Stapled-Peptides Tailored Against Initiation of Translation also contains other interesting chemical elements:

Iodine

(I)

5 atoms

The binding sites of Chlorine atom in the Stapled-Peptides Tailored Against Initiation of Translation (pdb code 5zk7). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Stapled-Peptides Tailored Against Initiation of Translation, PDB code: 5zk7:

Chlorine binding site 1 out of 1 in the Stapled-Peptides Tailored Against Initiation of Translation


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Stapled-Peptides Tailored Against Initiation of Translation within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1005 b:43.1 occ:1.00 NH2 A:ARG128 3.3 49.3 1.0 NE C:ARG12 3.4 48.1 1.0 CG A:ARG128 3.5 40.6 1.0 O A:LEU187 3.6 34.5 1.0 NH2 C:ARG12 3.7 49.0 1.0 CZ C:ARG12 4.0 47.7 1.0 CD A:ARG128 4.0 43.4 1.0 O A:ARG186 4.2 31.6 1.0 C A:LEU187 4.2 34.3 1.0 CG A:GLU132 4.2 28.7 1.0 CZ A:ARG128 4.3 48.0 1.0 CB A:GLU132 4.3 27.9 1.0 O A:ARG128 4.3 30.3 1.0 CD C:ARG12 4.3 46.4 1.0 CA A:LEU187 4.4 33.8 1.0 CD1 A:PHE129 4.4 30.1 1.0 N C:NH213 4.5 36.0 1.0 OE2 A:GLU132 4.5 29.7 1.0 NE A:ARG128 4.5 45.9 1.0 CB C:ARG12 4.6 41.6 1.0 CE1 A:PHE129 4.7 30.7 1.0 CD A:GLU132 4.7 29.6 1.0 C A:ARG128 4.7 30.9 1.0 CB A:ARG128 4.8 36.5 1.0

D.Lama, A.M.Liberatore, Y.Frosi, J.Nakhle, N.Tsomaia, T.Bashir, D.P.Lane, C.J.Brown, C.S.Verma, S.Auvin. Structural Insights Reveal A Recognition Feature For Tailoring Hydrocarbon Stapled-Peptides Against the Eukaryotic Translation Initiation Factor 4E Protein. Chem Sci V. 10 2489 2019.
ISSN: ISSN 2041-6520
PubMed: 30881679
DOI: 10.1039/C8SC03759K