Chlorine in PDB 5zto: Crystal Structure of Egfr 696-1022 T790M/C797S in Complex with D3003

All present enzymatic activity of Crystal Structure of Egfr 696-1022 T790M/C797S in Complex with D3003:
2.7.10.1;

The structure of Crystal Structure of Egfr 696-1022 T790M/C797S in Complex with D3003, PDB code: 5zto was solved by S.J.Zhu, C.H.Yun, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.03 / 2.65
Space group	I 2 3
Cell size a, b, c (Å), α, β, γ (°)	148.731, 148.731, 148.731, 90.00, 90.00, 90.00
R / Rfree (%)	23.1 / 27.2

The binding sites of Chlorine atom in the Crystal Structure of Egfr 696-1022 T790M/C797S in Complex with D3003 (pdb code 5zto). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Egfr 696-1022 T790M/C797S in Complex with D3003, PDB code: 5zto:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of Egfr 696-1022 T790M/C797S in Complex with D3003


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Egfr 696-1022 T790M/C797S in Complex with D3003 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1101 b:66.7 occ:1.00 CL1 A:9JO1101 0.0 66.7 1.0 CBF A:9JO1101 1.8 60.3 1.0 CAI A:9JO1101 2.7 63.7 1.0 CBK A:9JO1101 2.8 56.2 1.0 NBQ A:9JO1101 3.0 55.2 1.0 CAX A:9JO1101 3.2 53.4 1.0 O A:ALA743 3.5 49.6 1.0 CB A:ALA743 3.7 49.0 1.0 C A:ALA743 3.7 56.2 1.0 CG1 A:VAL726 3.8 62.4 1.0 CB A:MET790 3.8 60.6 1.0 CB A:LYS745 3.8 61.1 1.0 CBD A:9JO1101 3.8 53.7 1.0 CG A:MET790 3.8 67.0 1.0 N A:LYS745 3.9 58.4 1.0 CAG A:9JO1101 4.0 70.4 1.0 CAJ A:9JO1101 4.0 59.4 1.0 N A:ILE744 4.1 60.5 1.0 O A:LEU788 4.1 57.7 1.0 OAE A:9JO1101 4.2 59.8 1.0 C5 A:9JO1101 4.3 49.3 1.0 C A:ILE744 4.3 59.9 1.0 CA A:ALA743 4.4 52.7 1.0 CA A:LYS745 4.4 64.4 1.0 CA A:ILE744 4.5 56.3 1.0 N A:MET790 4.5 57.4 1.0 CAH A:9JO1101 4.5 66.6 1.0 NBR A:9JO1101 4.7 51.9 1.0 CA A:MET790 4.8 60.7 1.0 C4 A:9JO1101 4.8 49.5 1.0 CG A:LYS745 4.9 63.5 1.0 C A:LEU788 4.9 60.1 1.0 CD A:LYS745 5.0 59.0 1.0 SD A:MET790 5.0 88.8 1.0 O A:ILE744 5.0 63.8 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of Egfr 696-1022 T790M/C797S in Complex with D3003


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Egfr 696-1022 T790M/C797S in Complex with D3003 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1102 b:0.7 occ:1.00 N A:ILE878 3.2 81.7 1.0 CG A:LYS879 3.2 75.6 1.0 N A:LYS879 3.3 77.7 1.0 CA A:PRO877 3.3 86.5 1.0 C A:PRO877 3.3 82.7 1.0 CB A:LYS879 3.6 72.7 1.0 N A:PRO877 3.8 87.7 1.0 CG2 A:ILE878 3.9 80.1 1.0 CZ3 A:TRP880 4.0 49.4 1.0 CA A:LYS879 4.1 79.4 1.0 CE3 A:TRP880 4.2 54.9 1.0 CA A:ILE878 4.2 84.0 1.0 O A:PRO877 4.2 81.9 1.0 C A:ILE878 4.2 79.7 1.0 CD A:LYS879 4.4 78.6 1.0 CB A:PRO877 4.7 81.7 1.0 CB A:ILE878 4.7 87.6 1.0 CE A:LYS879 4.9 78.2 1.0

S.J.Zhu, C.H.Yun. Crystal Structure of Egfr 696-1022 T790M/C797S in Complex with D3003 To Be Published.