Chlorine in PDB 6ale: A V-to-F Substitution in SK2 Channels Causes CA2+ Hypersensitivity and Improves Locomotion in A C. Elegans Als Model

The structure of A V-to-F Substitution in SK2 Channels Causes CA2+ Hypersensitivity and Improves Locomotion in A C. Elegans Als Model, PDB code: 6ale was solved by Y.W.Nam, M.Zhang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	24.19 / 2.50
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	76.653, 66.913, 64.712, 90.00, 92.47, 90.00
R / Rfree (%)	18.8 / 25.5

The structure of A V-to-F Substitution in SK2 Channels Causes CA2+ Hypersensitivity and Improves Locomotion in A C. Elegans Als Model also contains other interesting chemical elements:

Calcium

(Ca)

2 atoms

The binding sites of Chlorine atom in the A V-to-F Substitution in SK2 Channels Causes CA2+ Hypersensitivity and Improves Locomotion in A C. Elegans Als Model (pdb code 6ale). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the A V-to-F Substitution in SK2 Channels Causes CA2+ Hypersensitivity and Improves Locomotion in A C. Elegans Als Model, PDB code: 6ale:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the A V-to-F Substitution in SK2 Channels Causes CA2+ Hypersensitivity and Improves Locomotion in A C. Elegans Als Model


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of A V-to-F Substitution in SK2 Channels Causes CA2+ Hypersensitivity and Improves Locomotion in A C. Elegans Als Model within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl504 b:0.2 occ:1.00 CL1 B:1KP504 0.0 0.2 1.0 C4 B:1KP504 1.8 0.6 1.0 C3 B:1KP504 2.8 0.5 1.0 C5 B:1KP504 2.8 1.0 1.0 SD R:MET71 3.2 78.8 1.0 CL B:1KP504 3.2 0.2 1.0 CE R:MET71 3.5 80.5 1.0 CG R:MET71 3.9 72.4 1.0 CG2 R:VAL55 4.0 61.4 1.0 C2 B:1KP504 4.1 0.2 1.0 C6 B:1KP504 4.2 0.8 1.0 CD1 B:LEU480 4.3 28.5 1.0 CB B:ALA477 4.3 19.8 1.0 O B:ALA477 4.5 23.3 1.0 CA B:ALA477 4.6 24.6 1.0 CG2 B:VAL481 4.6 24.3 1.0 C1 B:1KP504 4.7 0.1 1.0 CB B:LEU480 4.7 23.2 1.0 C B:ALA477 5.0 23.1 1.0 CB R:MET71 5.0 73.5 1.0

Chlorine binding site 2 out of 2 in the A V-to-F Substitution in SK2 Channels Causes CA2+ Hypersensitivity and Improves Locomotion in A C. Elegans Als Model


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of A V-to-F Substitution in SK2 Channels Causes CA2+ Hypersensitivity and Improves Locomotion in A C. Elegans Als Model within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl504 b:0.2 occ:1.00 CL B:1KP504 0.0 0.2 1.0 C5 B:1KP504 1.8 1.0 1.0 C4 B:1KP504 2.8 0.6 1.0 C6 B:1KP504 2.9 0.8 1.0 O R:MET51 3.0 41.9 1.0 CL1 B:1KP504 3.2 0.2 1.0 N1 B:1KP504 3.4 0.8 1.0 CG2 R:VAL55 3.4 61.4 1.0 CB R:GLU54 3.5 50.5 1.0 C R:MET51 3.8 50.7 1.0 CA R:MET51 3.9 51.3 1.0 CG R:MET51 3.9 60.5 1.0 CG R:GLU54 4.1 56.0 1.0 C3 B:1KP504 4.1 0.5 1.0 C1 B:1KP504 4.2 0.1 1.0 CB R:MET51 4.2 49.5 1.0 N R:VAL55 4.3 56.5 1.0 CZ B:PHE410 4.4 67.2 1.0 CB B:ALA477 4.4 19.8 1.0 CA R:GLU54 4.5 54.3 1.0 C R:GLU54 4.5 53.7 1.0 CB R:VAL55 4.5 61.0 1.0 C2 B:1KP504 4.7 0.2 1.0 C7 B:1KP504 4.7 0.6 1.0 CG R:MET71 4.8 72.4 1.0 N R:GLU54 4.9 50.2 1.0 CE1 B:PHE410 4.9 67.6 1.0 CA R:VAL55 5.0 61.4 1.0

Y.W.Nam, M.Zhang. Calcium-Calmodulin Complexed with the Calmodulin Binding Domain From A Mutant Small Conductance Potassium Channel and NS309 To Be Published.