Chlorine in PDB 6arx: Crystal Structure of An Insecticide-Resistant Acetylcholinesterase Mutant From the Malaria Vector Anopheles Gambiae in the Ligand-Free State

Enzymatic activity of Crystal Structure of An Insecticide-Resistant Acetylcholinesterase Mutant From the Malaria Vector Anopheles Gambiae in the Ligand-Free State

All present enzymatic activity of Crystal Structure of An Insecticide-Resistant Acetylcholinesterase Mutant From the Malaria Vector Anopheles Gambiae in the Ligand-Free State:
3.1.1.7;

Protein crystallography data

The structure of Crystal Structure of An Insecticide-Resistant Acetylcholinesterase Mutant From the Malaria Vector Anopheles Gambiae in the Ligand-Free State, PDB code: 6arx was solved by J.Cheung, A.Mahmood, R.Kalathur, L.Lixuan, P.R.Carlier, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 49.10 / 2.30
Space group P 61
Cell size a, b, c (Å), α, β, γ (°) 149.599, 149.599, 225.857, 90.00, 90.00, 120.00
R / Rfree (%) 17.8 / 20.3

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of An Insecticide-Resistant Acetylcholinesterase Mutant From the Malaria Vector Anopheles Gambiae in the Ligand-Free State (pdb code 6arx). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of An Insecticide-Resistant Acetylcholinesterase Mutant From the Malaria Vector Anopheles Gambiae in the Ligand-Free State, PDB code: 6arx:

Chlorine binding site 1 out of 1 in 6arx

Go back to Chlorine Binding Sites List in 6arx
Chlorine binding site 1 out of 1 in the Crystal Structure of An Insecticide-Resistant Acetylcholinesterase Mutant From the Malaria Vector Anopheles Gambiae in the Ligand-Free State


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of An Insecticide-Resistant Acetylcholinesterase Mutant From the Malaria Vector Anopheles Gambiae in the Ligand-Free State within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1005

b:57.7
occ:1.00
NH1 A:ARG376 3.2 47.8 1.0
NH2 A:ARG376 3.5 44.5 1.0
CA A:ARG472 3.7 49.2 1.0
CZ A:ARG376 3.8 57.0 1.0
CB A:ARG472 3.8 49.0 1.0
C A:ARG472 4.0 50.5 1.0
CG A:ARG472 4.0 52.8 1.0
N A:PHE473 4.1 43.8 1.0
CD A:ARG472 4.7 49.5 1.0
O A:ARG472 4.7 47.2 1.0
O A:PHE473 4.9 51.1 1.0
O A:GLY471 4.9 45.7 1.0
CA A:PHE473 4.9 46.4 1.0
N A:ARG472 5.0 40.7 1.0

Reference:

J.Cheung, A.Mahmood, R.Kalathur, L.Liu, P.R.Carlier. Structure of the G119S Mutant Acetylcholinesterase of the Malaria Vector Anopheles Gambiae Reveals Basis of Insecticide Resistance. Structure V. 26 130 2018.
ISSN: ISSN 1878-4186
PubMed: 29276037
DOI: 10.1016/J.STR.2017.11.021
Page generated: Sat Dec 12 12:44:26 2020

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