Atomistry » Chlorine » PDB 6axw-6b4f » 6b1u
Atomistry »
  Chlorine »
    PDB 6axw-6b4f »
      6b1u »

Chlorine in PDB 6b1u: Structure of Full-Length Human Ampk (A2B1G1) in Complex with A Small Molecule Activator SC4

Enzymatic activity of Structure of Full-Length Human Ampk (A2B1G1) in Complex with A Small Molecule Activator SC4

All present enzymatic activity of Structure of Full-Length Human Ampk (A2B1G1) in Complex with A Small Molecule Activator SC4:
2.7.11.1; 2.7.11.27; 2.7.11.31;

Protein crystallography data

The structure of Structure of Full-Length Human Ampk (A2B1G1) in Complex with A Small Molecule Activator SC4, PDB code: 6b1u was solved by K.R.W.Ngoei, C.G.Langendorf, N.X.Y.Ling, A.Hoque, S.Johnson, M.C.Camerino, S.R.Walker, Y.E.Bozikis, T.A.Dite, A.J.Ovens, W.J.Smiles, R.Jacobs, H.Huang, M.W.Parker, J.W.Scott, M.H.Rider, B.E.Kemp, R.C.Foitzik, J.B.Baell, J.S.Oakhill, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 48.64 / 2.77
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 75.827, 133.897, 141.725, 90.00, 92.74, 90.00
R / Rfree (%) 19.4 / 22.6

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Structure of Full-Length Human Ampk (A2B1G1) in Complex with A Small Molecule Activator SC4 (pdb code 6b1u). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Structure of Full-Length Human Ampk (A2B1G1) in Complex with A Small Molecule Activator SC4, PDB code: 6b1u:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in 6b1u

Go back to Chlorine Binding Sites List in 6b1u
Chlorine binding site 1 out of 3 in the Structure of Full-Length Human Ampk (A2B1G1) in Complex with A Small Molecule Activator SC4


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of Full-Length Human Ampk (A2B1G1) in Complex with A Small Molecule Activator SC4 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl602

b:63.6
occ:0.50
CL1 A:CG7602 0.0 63.6 0.5
CL1 A:CG7602 0.3 57.6 0.5
CAY A:CG7602 1.7 62.2 0.5
CAY A:CG7602 1.8 56.2 0.5
CBF A:CG7602 2.7 60.7 0.5
CAQ A:CG7602 2.7 62.3 0.5
CBF A:CG7602 2.8 54.6 0.5
CAQ A:CG7602 2.8 56.1 0.5
CAN A:CG7602 2.9 57.6 0.5
CBB A:CG7602 3.0 52.7 0.5
CBB A:CG7602 3.0 58.6 0.5
CAN A:CG7602 3.0 51.9 0.5
CG1 B:VAL113 3.5 64.4 1.0
CG1 B:VAL81 3.9 66.8 1.0
CBG A:CG7602 3.9 62.4 0.5
NAS A:CG7602 3.9 61.3 0.5
CAO A:CG7602 4.0 51.8 0.5
CAL A:CG7602 4.0 56.9 0.5
CAL A:CG7602 4.0 51.2 0.5
CD1 B:ILE115 4.0 76.5 1.0
NAS A:CG7602 4.0 55.1 0.5
CBG A:CG7602 4.1 56.0 0.5
CAO A:CG7602 4.1 57.6 0.5
CZ A:PHE90 4.1 57.3 1.0
CE2 A:PHE90 4.2 58.1 1.0
CG1 A:VAL11 4.3 67.6 1.0
CG2 B:VAL113 4.3 64.1 1.0
CBH A:CG7602 4.4 62.2 0.5
CB B:VAL113 4.5 64.6 1.0
CG1 B:ILE115 4.5 70.1 1.0
CBH A:CG7602 4.5 55.8 0.5
CG2 B:VAL81 4.6 67.6 1.0
CD1 A:LEU18 4.7 53.1 1.0
CAM A:CG7602 4.8 51.1 0.5
CBA A:CG7602 4.8 50.9 0.5
CBA A:CG7602 4.9 56.4 0.5
CAM A:CG7602 4.9 56.8 0.5
CB B:VAL81 5.0 67.7 1.0
CD1 A:ILE46 5.0 56.0 1.0

Chlorine binding site 2 out of 3 in 6b1u

Go back to Chlorine Binding Sites List in 6b1u
Chlorine binding site 2 out of 3 in the Structure of Full-Length Human Ampk (A2B1G1) in Complex with A Small Molecule Activator SC4


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structure of Full-Length Human Ampk (A2B1G1) in Complex with A Small Molecule Activator SC4 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl602

b:57.6
occ:0.50
CL1 A:CG7602 0.0 57.6 0.5
CL1 A:CG7602 0.3 63.6 0.5
CAY A:CG7602 1.6 62.2 0.5
CAY A:CG7602 1.7 56.2 0.5
CAQ A:CG7602 2.6 62.3 0.5
CBF A:CG7602 2.7 60.7 0.5
CBF A:CG7602 2.7 54.6 0.5
CAQ A:CG7602 2.7 56.1 0.5
CAN A:CG7602 2.9 57.6 0.5
CAN A:CG7602 2.9 51.9 0.5
CBB A:CG7602 3.0 52.7 0.5
CBB A:CG7602 3.0 58.6 0.5
CBG A:CG7602 3.8 62.4 0.5
CG1 B:VAL113 3.8 64.4 1.0
NAS A:CG7602 3.9 61.3 0.5
CZ A:PHE90 3.9 57.3 1.0
CE2 A:PHE90 3.9 58.1 1.0
CBG A:CG7602 3.9 56.0 0.5
NAS A:CG7602 3.9 55.1 0.5
CAL A:CG7602 4.0 51.2 0.5
CAL A:CG7602 4.0 56.9 0.5
CD1 B:ILE115 4.0 76.5 1.0
CG1 B:VAL81 4.1 66.8 1.0
CAO A:CG7602 4.1 51.8 0.5
CAO A:CG7602 4.2 57.6 0.5
CBH A:CG7602 4.3 62.2 0.5
CG1 A:VAL11 4.4 67.6 1.0
CBH A:CG7602 4.4 55.8 0.5
CG2 B:VAL113 4.5 64.1 1.0
CD1 A:LEU18 4.5 53.1 1.0
CG1 B:ILE115 4.6 70.1 1.0
CG2 B:VAL81 4.7 67.6 1.0
CD1 A:ILE46 4.7 56.0 1.0
CB B:VAL113 4.7 64.6 1.0
CBA A:CG7602 4.9 50.9 0.5
CAM A:CG7602 4.9 51.1 0.5
CBA A:CG7602 4.9 56.4 0.5
NAR A:CG7602 5.0 62.7 0.5

Chlorine binding site 3 out of 3 in 6b1u

Go back to Chlorine Binding Sites List in 6b1u
Chlorine binding site 3 out of 3 in the Structure of Full-Length Human Ampk (A2B1G1) in Complex with A Small Molecule Activator SC4


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Structure of Full-Length Human Ampk (A2B1G1) in Complex with A Small Molecule Activator SC4 within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl602

b:48.7
occ:1.00
CL1 C:CG7602 0.0 48.7 1.0
CAY C:CG7602 1.7 45.8 1.0
CBF C:CG7602 2.7 44.2 1.0
CAQ C:CG7602 2.7 44.7 1.0
CAO C:CG7602 2.9 43.0 1.0
CBB C:CG7602 3.0 42.8 1.0
CG1 D:VAL113 3.8 44.5 1.0
CG1 D:VAL81 3.9 43.0 1.0
CBG C:CG7602 3.9 45.6 1.0
NAS C:CG7602 3.9 44.9 1.0
CAM C:CG7602 4.0 43.3 1.0
CZ C:PHE90 4.0 47.2 1.0
CAN C:CG7602 4.1 41.7 1.0
CD1 D:ILE115 4.1 53.7 1.0
CG2 D:VAL113 4.1 45.1 1.0
CE2 C:PHE90 4.2 48.1 1.0
CG2 D:VAL81 4.4 43.6 1.0
CBH C:CG7602 4.4 45.9 1.0
CB D:VAL113 4.5 44.8 1.0
CG1 D:ILE115 4.6 47.1 1.0
CD1 C:LEU18 4.6 44.6 1.0
CG1 C:VAL11 4.7 59.3 1.0
CB D:VAL81 4.8 43.6 1.0
CD1 C:ILE46 4.8 52.3 1.0
CBA C:CG7602 4.9 43.0 1.0
CAL C:CG7602 4.9 41.5 1.0

Reference:

K.R.W.Ngoei, C.G.Langendorf, N.X.Y.Ling, A.Hoque, S.Varghese, M.A.Camerino, S.R.Walker, Y.E.Bozikis, T.A.Dite, A.J.Ovens, W.J.Smiles, R.Jacobs, H.Huang, M.W.Parker, J.W.Scott, M.H.Rider, R.C.Foitzik, B.E.Kemp, J.B.Baell, J.S.Oakhill. Structural Determinants For Small-Molecule Activation of Skeletal Muscle Ampk Alpha 2 Beta 2 Gamma 1 By the Glucose Importagog SC4. Cell Chem Biol V. 25 728 2018.
ISSN: ESSN 2451-9448
PubMed: 29657085
DOI: 10.1016/J.CHEMBIOL.2018.03.008
Page generated: Fri Jul 26 22:25:08 2024

Last articles

Cl in 2W0U
Cl in 2VYX
Cl in 2W0R
Cl in 2W0D
Cl in 2VX3
Cl in 2VZ5
Cl in 2VYO
Cl in 2VYA
Cl in 2VY3
Cl in 2VY0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy