Chlorine in PDB 6b27: Crystal Structure of Human STAC2 Tandem SH3 Domains (296-411) in Complex with A CAV1.1 II-III Loop Peptide

The structure of Crystal Structure of Human STAC2 Tandem SH3 Domains (296-411) in Complex with A CAV1.1 II-III Loop Peptide, PDB code: 6b27 was solved by S.M.Wong King Yuen, F.Van Petegem, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	35.00 / 1.73
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	47.920, 114.650, 144.678, 90.00, 90.00, 90.00
R / Rfree (%)	17.9 / 21.6

The binding sites of Chlorine atom in the Crystal Structure of Human STAC2 Tandem SH3 Domains (296-411) in Complex with A CAV1.1 II-III Loop Peptide (pdb code 6b27). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Human STAC2 Tandem SH3 Domains (296-411) in Complex with A CAV1.1 II-III Loop Peptide, PDB code: 6b27:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of Human STAC2 Tandem SH3 Domains (296-411) in Complex with A CAV1.1 II-III Loop Peptide


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human STAC2 Tandem SH3 Domains (296-411) in Complex with A CAV1.1 II-III Loop Peptide within 5.0Å range: probe atom residue distance (Å) B Occ E:Cl501 b:27.4 occ:1.00 O E:HOH679 2.8 32.8 1.0 NH1 E:ARG337 3.0 21.5 1.0 N E:ALA312 3.3 15.8 1.0 CD E:ARG337 3.7 20.8 1.0 CB E:ALA312 3.9 17.2 1.0 CD1 E:LEU311 3.9 19.1 1.0 CA E:LEU311 4.0 16.8 1.0 O E:ASP310 4.0 20.2 1.0 C E:LEU311 4.1 17.7 1.0 CZ E:ARG337 4.1 18.0 1.0 CA E:ALA312 4.2 15.9 1.0 NE E:ARG337 4.4 20.0 1.0 CG E:ARG337 4.5 21.1 1.0 CB E:ARG337 4.5 20.9 1.0 O E:ALA312 4.7 18.9 1.0 CG E:LEU311 4.8 19.1 1.0 C E:ASP310 4.9 16.9 1.0 CB E:LEU311 4.9 18.6 1.0 N E:LEU311 4.9 17.4 1.0 C E:ALA312 5.0 17.1 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of Human STAC2 Tandem SH3 Domains (296-411) in Complex with A CAV1.1 II-III Loop Peptide


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Human STAC2 Tandem SH3 Domains (296-411) in Complex with A CAV1.1 II-III Loop Peptide within 5.0Å range: probe atom residue distance (Å) B Occ E:Cl502 b:41.4 occ:1.00 N E:GLU375 2.9 17.6 1.0 O E:HOH613 3.1 39.0 1.0 CB E:GLU375 3.5 21.9 1.0 CB E:PRO361 3.8 20.0 1.0 CA E:LYS374 3.8 16.7 1.0 C E:LYS374 3.8 16.9 1.0 CA E:GLU375 3.8 20.5 1.0 CB E:LYS374 4.0 17.4 1.0 CG E:PRO361 4.1 20.9 1.0 O E:GLU375 4.6 18.2 1.0 CD E:PRO361 4.7 19.3 1.0 C E:GLU375 4.7 17.6 1.0 OE1 E:GLU375 4.9 38.3 1.0 O E:LYS374 4.9 17.4 1.0 O E:HOH639 5.0 33.4 1.0 CA E:PRO361 5.0 16.4 1.0

S.M.Wong King Yuen, M.Campiglio, C.C.Tung, B.E.Flucher, F.Van Petegem. Structural Insights Into Binding of Stac Proteins to Voltage-Gated Calcium Channels. Proc. Natl. Acad. Sci. V. 114 E9520 2017U.S.A..
ISSN: ESSN 1091-6490
PubMed: 29078335
DOI: 10.1073/PNAS.1708852114