Chlorine in PDB 6b5v: Structure of TRPV5 in Complex with Econazole

The structure of Structure of TRPV5 in Complex with Econazole also contains other interesting chemical elements:

Calcium

(Ca)

1 atom

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 12;

Binding sites:

The binding sites of Chlorine atom in the Structure of TRPV5 in Complex with Econazole (pdb code 6b5v). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 12 binding sites of Chlorine where determined in the Structure of TRPV5 in Complex with Econazole, PDB code: 6b5v:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Chlorine binding site 1 out of 12 in the Structure of TRPV5 in Complex with Econazole


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of TRPV5 in Complex with Econazole within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1001 b:30.0 occ:1.00 CL2 A:ECL1001 0.0 30.0 1.0 C11 A:ECL1001 1.8 30.0 1.0 C13 A:ECL1001 2.7 30.0 1.0 H13 A:ECL1001 2.8 30.0 1.0 C9 A:ECL1001 2.9 30.0 1.0 H9 A:ECL1001 3.0 30.0 1.0 CE1 A:PHE456 3.4 0.7 1.0 CZ A:PHE456 3.9 0.7 1.0 C10 A:ECL1001 4.1 30.0 1.0 C2 A:ECL1001 4.1 30.0 1.0 CD1 A:PHE456 4.6 0.7 1.0 C1 A:ECL1001 4.6 30.0 1.0 H10 A:ECL1001 4.8 30.0 1.0 H2 A:ECL1001 4.8 30.0 1.0

Chlorine binding site 2 out of 12 in the Structure of TRPV5 in Complex with Econazole


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structure of TRPV5 in Complex with Econazole within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1001 b:30.0 occ:1.00 CL4 A:ECL1001 0.0 30.0 1.0 C14 A:ECL1001 1.8 30.0 1.0 C5 A:ECL1001 2.7 30.0 1.0 H5 A:ECL1001 2.8 30.0 1.0 C15 A:ECL1001 2.9 30.0 1.0 H15 A:ECL1001 3.0 30.0 1.0 CE1 A:PHE425 3.4 0.8 1.0 CZ A:PHE425 3.4 0.8 1.0 CD1 A:ILE482 3.6 0.3 1.0 C16 A:ECL1001 4.1 30.0 1.0 C21 A:ECL1001 4.1 30.0 1.0 CB A:GLN483 4.4 0.1 1.0 CG A:GLN483 4.5 0.1 1.0 CD1 A:PHE425 4.6 0.8 1.0 CE2 A:PHE425 4.6 0.8 1.0 C17 A:ECL1001 4.6 30.0 1.0 CA A:GLN483 4.7 0.1 1.0 H21 A:ECL1001 4.8 30.0 1.0 N A:GLN483 5.0 0.1 1.0

Chlorine binding site 3 out of 12 in the Structure of TRPV5 in Complex with Econazole


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Structure of TRPV5 in Complex with Econazole within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1001 b:30.0 occ:1.00 CL8 A:ECL1001 0.0 30.0 1.0 C16 A:ECL1001 1.8 30.0 1.0 H8A A:ECL1001 2.6 30.0 1.0 C15 A:ECL1001 2.7 30.0 1.0 H15 A:ECL1001 2.7 30.0 1.0 O20 A:ECL1001 2.7 30.0 1.0 C8 A:ECL1001 2.9 30.0 1.0 C17 A:ECL1001 2.9 30.0 1.0 H8 A:ECL1001 2.9 30.0 1.0 C20 A:ECL1001 3.3 30.0 1.0 H20 A:ECL1001 3.7 30.0 1.0 SG A:CYS463 3.9 0.8 1.0 C14 A:ECL1001 4.1 30.0 1.0 C21 A:ECL1001 4.1 30.0 1.0 CD1 C:ILE565 4.4 0.7 1.0 C1 A:ECL1001 4.4 30.0 1.0 C19 A:ECL1001 4.6 30.0 1.0 C5 A:ECL1001 4.6 30.0 1.0 H19A A:ECL1001 4.8 30.0 1.0 H19 A:ECL1001 4.8 30.0 1.0 H21 A:ECL1001 4.9 30.0 1.0 H2 A:ECL1001 4.9 30.0 1.0

Chlorine binding site 4 out of 12 in the Structure of TRPV5 in Complex with Econazole


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Structure of TRPV5 in Complex with Econazole within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1001 b:30.0 occ:1.00 CL2 B:ECL1001 0.0 30.0 1.0 C11 B:ECL1001 1.8 30.0 1.0 C13 B:ECL1001 2.7 30.0 1.0 H13 B:ECL1001 2.8 30.0 1.0 C9 B:ECL1001 2.9 30.0 1.0 H9 B:ECL1001 3.0 30.0 1.0 CE1 B:PHE456 3.4 0.7 1.0 CZ B:PHE456 3.9 0.7 1.0 C10 B:ECL1001 4.1 30.0 1.0 C2 B:ECL1001 4.1 30.0 1.0 CD1 B:PHE456 4.6 0.7 1.0 C1 B:ECL1001 4.6 30.0 1.0 H10 B:ECL1001 4.8 30.0 1.0 H2 B:ECL1001 4.8 30.0 1.0

Chlorine binding site 5 out of 12 in the Structure of TRPV5 in Complex with Econazole


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Structure of TRPV5 in Complex with Econazole within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1001 b:30.0 occ:1.00 CL4 B:ECL1001 0.0 30.0 1.0 C14 B:ECL1001 1.8 30.0 1.0 C5 B:ECL1001 2.7 30.0 1.0 H5 B:ECL1001 2.8 30.0 1.0 C15 B:ECL1001 2.9 30.0 1.0 H15 B:ECL1001 3.0 30.0 1.0 CE1 B:PHE425 3.4 0.8 1.0 CZ B:PHE425 3.5 0.8 1.0 CD1 B:ILE482 3.6 0.3 1.0 C16 B:ECL1001 4.1 30.0 1.0 C21 B:ECL1001 4.1 30.0 1.0 CB B:GLN483 4.4 0.1 1.0 CG B:GLN483 4.5 0.1 1.0 CD1 B:PHE425 4.6 0.8 1.0 CE2 B:PHE425 4.6 0.8 1.0 C17 B:ECL1001 4.6 30.0 1.0 CA B:GLN483 4.7 0.1 1.0 H21 B:ECL1001 4.8 30.0 1.0 N B:GLN483 5.0 0.1 1.0

Chlorine binding site 6 out of 12 in the Structure of TRPV5 in Complex with Econazole


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Structure of TRPV5 in Complex with Econazole within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1001 b:30.0 occ:1.00 CL8 B:ECL1001 0.0 30.0 1.0 C16 B:ECL1001 1.8 30.0 1.0 H8A B:ECL1001 2.6 30.0 1.0 C15 B:ECL1001 2.7 30.0 1.0 H15 B:ECL1001 2.7 30.0 1.0 O20 B:ECL1001 2.7 30.0 1.0 C8 B:ECL1001 2.9 30.0 1.0 C17 B:ECL1001 2.9 30.0 1.0 H8 B:ECL1001 2.9 30.0 1.0 C20 B:ECL1001 3.3 30.0 1.0 H20 B:ECL1001 3.7 30.0 1.0 SG B:CYS463 3.9 0.8 1.0 C14 B:ECL1001 4.1 30.0 1.0 C21 B:ECL1001 4.1 30.0 1.0 C1 B:ECL1001 4.4 30.0 1.0 CD1 A:ILE565 4.5 0.7 1.0 C19 B:ECL1001 4.6 30.0 1.0 C5 B:ECL1001 4.6 30.0 1.0 H19A B:ECL1001 4.8 30.0 1.0 H19 B:ECL1001 4.8 30.0 1.0 H21 B:ECL1001 4.9 30.0 1.0 H2 B:ECL1001 4.9 30.0 1.0

Chlorine binding site 7 out of 12 in the Structure of TRPV5 in Complex with Econazole


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 7 of Structure of TRPV5 in Complex with Econazole within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl1001 b:30.0 occ:1.00 CL2 D:ECL1001 0.0 30.0 1.0 C11 D:ECL1001 1.8 30.0 1.0 C13 D:ECL1001 2.7 30.0 1.0 H13 D:ECL1001 2.8 30.0 1.0 C9 D:ECL1001 2.9 30.0 1.0 H9 D:ECL1001 3.0 30.0 1.0 CE1 D:PHE456 3.4 0.7 1.0 CZ D:PHE456 3.9 0.7 1.0 C10 D:ECL1001 4.1 30.0 1.0 C2 D:ECL1001 4.1 30.0 1.0 CD1 D:PHE456 4.6 0.7 1.0 C1 D:ECL1001 4.6 30.0 1.0 H10 D:ECL1001 4.8 30.0 1.0 H2 D:ECL1001 4.8 30.0 1.0

Chlorine binding site 8 out of 12 in the Structure of TRPV5 in Complex with Econazole


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 8 of Structure of TRPV5 in Complex with Econazole within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl1001 b:30.0 occ:1.00 CL4 D:ECL1001 0.0 30.0 1.0 C14 D:ECL1001 1.8 30.0 1.0 C5 D:ECL1001 2.7 30.0 1.0 H5 D:ECL1001 2.8 30.0 1.0 C15 D:ECL1001 2.9 30.0 1.0 H15 D:ECL1001 3.0 30.0 1.0 CE1 D:PHE425 3.4 0.8 1.0 CZ D:PHE425 3.4 0.8 1.0 CD1 D:ILE482 3.6 0.3 1.0 C16 D:ECL1001 4.1 30.0 1.0 C21 D:ECL1001 4.1 30.0 1.0 CB D:GLN483 4.4 0.1 1.0 CG D:GLN483 4.5 0.1 1.0 CD1 D:PHE425 4.6 0.8 1.0 CE2 D:PHE425 4.6 0.8 1.0 C17 D:ECL1001 4.6 30.0 1.0 CA D:GLN483 4.7 0.1 1.0 H21 D:ECL1001 4.8 30.0 1.0 N D:GLN483 5.0 0.1 1.0

Chlorine binding site 9 out of 12 in the Structure of TRPV5 in Complex with Econazole


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 9 of Structure of TRPV5 in Complex with Econazole within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl1001 b:30.0 occ:1.00 CL8 D:ECL1001 0.0 30.0 1.0 C16 D:ECL1001 1.8 30.0 1.0 H8A D:ECL1001 2.6 30.0 1.0 C15 D:ECL1001 2.7 30.0 1.0 H15 D:ECL1001 2.7 30.0 1.0 O20 D:ECL1001 2.7 30.0 1.0 C8 D:ECL1001 2.9 30.0 1.0 C17 D:ECL1001 2.9 30.0 1.0 H8 D:ECL1001 2.9 30.0 1.0 C20 D:ECL1001 3.3 30.0 1.0 H20 D:ECL1001 3.7 30.0 1.0 SG D:CYS463 3.9 0.8 1.0 C14 D:ECL1001 4.1 30.0 1.0 C21 D:ECL1001 4.1 30.0 1.0 CD1 B:ILE565 4.4 0.7 1.0 C1 D:ECL1001 4.4 30.0 1.0 C19 D:ECL1001 4.6 30.0 1.0 C5 D:ECL1001 4.6 30.0 1.0 H19A D:ECL1001 4.8 30.0 1.0 H19 D:ECL1001 4.8 30.0 1.0 H21 D:ECL1001 4.9 30.0 1.0 H2 D:ECL1001 4.9 30.0 1.0

Chlorine binding site 10 out of 12 in the Structure of TRPV5 in Complex with Econazole


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 10 of Structure of TRPV5 in Complex with Econazole within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl1001 b:30.0 occ:1.00 CL2 C:ECL1001 0.0 30.0 1.0 C11 C:ECL1001 1.8 30.0 1.0 C13 C:ECL1001 2.7 30.0 1.0 H13 C:ECL1001 2.8 30.0 1.0 C9 C:ECL1001 2.9 30.0 1.0 H9 C:ECL1001 3.0 30.0 1.0 CE1 C:PHE456 3.4 0.7 1.0 CZ C:PHE456 3.9 0.7 1.0 C10 C:ECL1001 4.1 30.0 1.0 C2 C:ECL1001 4.1 30.0 1.0 CD1 C:PHE456 4.6 0.7 1.0 C1 C:ECL1001 4.6 30.0 1.0 H10 C:ECL1001 4.8 30.0 1.0 H2 C:ECL1001 4.8 30.0 1.0

T.E.T.Hughes, D.T.Lodowski, K.W.Huynh, A.Yazici, J.Del Rosario, A.Kapoor, S.Basak, A.Samanta, X.Han, S.Chakrapani, Z.H.Zhou, M.Filizola, T.Rohacs, S.Han, V.Y.Moiseenkova-Bell. Structural Basis of TRPV5 Channel Inhibition By Econazole Revealed By Cryo-Em. Nat. Struct. Mol. Biol. V. 25 53 2018.
ISSN: ESSN 1545-9985
PubMed: 29323279
DOI: 10.1038/S41594-017-0009-1