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Chlorine in PDB 6b8j: Co-Structure of Human Glycogen Synthase Kinase Beta with A Selective (5-Imidazol-2-Yl-4-Phenylpyrimidin-2-Yl)[2-(2-Pyridylamino) Ethyl]Amine Inhibitor
Enzymatic activity of Co-Structure of Human Glycogen Synthase Kinase Beta with A Selective (5-Imidazol-2-Yl-4-Phenylpyrimidin-2-Yl)[2-(2-Pyridylamino) Ethyl]Amine Inhibitor
All present enzymatic activity of Co-Structure of Human Glycogen Synthase Kinase Beta with A Selective (5-Imidazol-2-Yl-4-Phenylpyrimidin-2-Yl)[2-(2-Pyridylamino) Ethyl]Amine Inhibitor:
2.7.11.1; 2.7.11.26;
2.7.11.1; 2.7.11.26;
Protein crystallography data
The structure of Co-Structure of Human Glycogen Synthase Kinase Beta with A Selective (5-Imidazol-2-Yl-4-Phenylpyrimidin-2-Yl)[2-(2-Pyridylamino) Ethyl]Amine Inhibitor, PDB code: 6b8j
was solved by
D.E.Bussiere,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 25.00 / 2.60 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 56.747, 65.070, 57.336, 90.00, 100.53, 90.00 |
| R / Rfree (%) | 21.2 / 24.7 |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Co-Structure of Human Glycogen Synthase Kinase Beta with A Selective (5-Imidazol-2-Yl-4-Phenylpyrimidin-2-Yl)[2-(2-Pyridylamino) Ethyl]Amine Inhibitor
(pdb code 6b8j). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Co-Structure of Human Glycogen Synthase Kinase Beta with A Selective (5-Imidazol-2-Yl-4-Phenylpyrimidin-2-Yl)[2-(2-Pyridylamino) Ethyl]Amine Inhibitor, PDB code: 6b8j:
Jump to Chlorine binding site number: 1; 2;
In total 2 binding sites of Chlorine where determined in the Co-Structure of Human Glycogen Synthase Kinase Beta with A Selective (5-Imidazol-2-Yl-4-Phenylpyrimidin-2-Yl)[2-(2-Pyridylamino) Ethyl]Amine Inhibitor, PDB code: 6b8j:
Jump to Chlorine binding site number: 1; 2;
Chlorine binding site 1 out of 2 in 6b8j
Go back to
Chlorine Binding Sites List in 6b8j
Chlorine binding site 1 out
of 2 in the Co-Structure of Human Glycogen Synthase Kinase Beta with A Selective (5-Imidazol-2-Yl-4-Phenylpyrimidin-2-Yl)[2-(2-Pyridylamino) Ethyl]Amine Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Co-Structure of Human Glycogen Synthase Kinase Beta with A Selective (5-Imidazol-2-Yl-4-Phenylpyrimidin-2-Yl)[2-(2-Pyridylamino) Ethyl]Amine Inhibitor within 5.0Å range:
|
Chlorine binding site 2 out of 2 in 6b8j
Go back to
Chlorine Binding Sites List in 6b8j
Chlorine binding site 2 out
of 2 in the Co-Structure of Human Glycogen Synthase Kinase Beta with A Selective (5-Imidazol-2-Yl-4-Phenylpyrimidin-2-Yl)[2-(2-Pyridylamino) Ethyl]Amine Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Co-Structure of Human Glycogen Synthase Kinase Beta with A Selective (5-Imidazol-2-Yl-4-Phenylpyrimidin-2-Yl)[2-(2-Pyridylamino) Ethyl]Amine Inhibitor within 5.0Å range:
|
Reference:
A.S.Wagman,
R.S.Boyce,
S.P.Brown,
E.Fang,
D.Goff,
J.M.Jansen,
V.P.Le,
B.H.Levine,
S.C.Ng,
Z.J.Ni,
J.M.Nuss,
K.B.Pfister,
S.Ramurthy,
P.A.Renhowe,
D.B.Ring,
W.Shu,
S.Subramanian,
X.A.Zhou,
C.M.Shafer,
S.D.Harrison,
K.W.Johnson,
D.E.Bussiere.
Synthesis, Binding Mode, and Antihyperglycemic Activity of Potent and Selective (5-Imidazol-2-Yl-4-Phenylpyrimidin-2-Yl)[2-(2-Pyridylamino) Ethyl]Amine Inhibitors of Glycogen Synthase Kinase 3. J. Med. Chem. V. 60 8482 2017.
ISSN: ISSN 1520-4804
PubMed: 29016121
DOI: 10.1021/ACS.JMEDCHEM.7B00922
Page generated: Sat Jul 12 11:46:43 2025
ISSN: ISSN 1520-4804
PubMed: 29016121
DOI: 10.1021/ACS.JMEDCHEM.7B00922
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