Chlorine in PDB 6bnc: Crystal Structure of the Intrinsic Colistin Resistance Enzyme Icr(Mc) From Moraxella Catarrhalis, Catalytic Domain, THR315ALA Mutant Di- Zinc and Peg Complex

The structure of Crystal Structure of the Intrinsic Colistin Resistance Enzyme Icr(Mc) From Moraxella Catarrhalis, Catalytic Domain, THR315ALA Mutant Di- Zinc and Peg Complex, PDB code: 6bnc was solved by P.J.Stogios, E.Evdokimova, Z.Wawrzak, A.Savchenko, W.F.Anderson, K.J.Satchell, A.Joachimiak, Center For Structural Genomics Ofinfectious Diseases (Csgid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.82 / 1.50
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	74.051, 154.246, 66.392, 90.00, 90.00, 90.00
R / Rfree (%)	13.2 / 15.3

The structure of Crystal Structure of the Intrinsic Colistin Resistance Enzyme Icr(Mc) From Moraxella Catarrhalis, Catalytic Domain, THR315ALA Mutant Di- Zinc and Peg Complex also contains other interesting chemical elements:

Zinc

(Zn)

4 atoms

The binding sites of Chlorine atom in the Crystal Structure of the Intrinsic Colistin Resistance Enzyme Icr(Mc) From Moraxella Catarrhalis, Catalytic Domain, THR315ALA Mutant Di- Zinc and Peg Complex (pdb code 6bnc). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of the Intrinsic Colistin Resistance Enzyme Icr(Mc) From Moraxella Catarrhalis, Catalytic Domain, THR315ALA Mutant Di- Zinc and Peg Complex, PDB code: 6bnc:

Chlorine binding site 1 out of 1 in the Crystal Structure of the Intrinsic Colistin Resistance Enzyme Icr(Mc) From Moraxella Catarrhalis, Catalytic Domain, THR315ALA Mutant Di- Zinc and Peg Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the Intrinsic Colistin Resistance Enzyme Icr(Mc) From Moraxella Catarrhalis, Catalytic Domain, THR315ALA Mutant Di- Zinc and Peg Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl605 b:29.3 occ:0.60 N B:GLN459 2.9 16.6 1.0 N B:ARG458 3.4 24.7 1.0 O B:HOH1175 3.5 53.6 1.0 CB B:GLN459 3.5 19.3 1.0 O B:HOH918 3.7 38.1 1.0 CB B:GLU457 3.8 32.9 1.0 CA B:GLN459 3.8 16.2 1.0 CB B:ARG458 3.8 23.2 1.0 C B:ARG458 3.8 19.8 1.0 CA B:ARG458 3.8 22.4 1.0 C B:GLU457 3.9 25.1 1.0 O B:HOH1163 4.0 46.8 1.0 CA B:GLU457 4.3 30.0 1.0 O B:GLU457 4.7 23.2 1.0 O B:HOH949 4.7 48.1 1.0 O B:HOH1176 4.7 60.1 1.0 CG B:GLU457 4.9 43.0 1.0 CG B:ARG458 4.9 21.2 1.0 OE2 B:GLU457 4.9 70.6 1.0 C B:GLN459 5.0 13.7 1.0 CD B:GLU457 5.0 74.4 1.0

P.J.Stogios, G.Cox, H.L.Zubyk, E.Evdokimova, Z.Wawrzak, G.D.Wright, A.Savchenko. Substrate Recognition By A Colistin Resistance Enzyme From Moraxella Catarrhalis. Acs Chem. Biol. V. 13 1322 2018.
ISSN: ESSN 1554-8937
PubMed: 29631403
DOI: 10.1021/ACSCHEMBIO.8B00116