Chlorine in PDB 6bor: Human APE1 Substrate Complex with An G/G Mismatch Adjacent the Thf

All present enzymatic activity of Human APE1 Substrate Complex with An G/G Mismatch Adjacent the Thf:
4.2.99.18;

The structure of Human APE1 Substrate Complex with An G/G Mismatch Adjacent the Thf, PDB code: 6bor was solved by B.D.Freudenthal, A.M.Whitaker, M.S.Fairlamb, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	24.81 / 1.84
Space group	P 1
Cell size a, b, c (Å), α, β, γ (°)	44.408, 60.204, 73.014, 82.94, 80.29, 89.10
R / Rfree (%)	17 / 20.9

The binding sites of Chlorine atom in the Human APE1 Substrate Complex with An G/G Mismatch Adjacent the Thf (pdb code 6bor). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Human APE1 Substrate Complex with An G/G Mismatch Adjacent the Thf, PDB code: 6bor:

Chlorine binding site 1 out of 1 in the Human APE1 Substrate Complex with An G/G Mismatch Adjacent the Thf


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human APE1 Substrate Complex with An G/G Mismatch Adjacent the Thf within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl404 b:16.1 occ:1.00 O P:HOH130 3.2 19.2 1.0 O A:HOH636 3.2 23.4 1.0 N A:SER129 3.3 12.1 1.0 NE2 A:GLN96 3.3 12.8 1.0 OH A:TYR171 3.4 21.8 1.0 C5' P:DG10 3.7 17.2 1.0 CE A:LYS98 3.7 18.6 1.0 CA A:TYR128 3.8 16.1 1.0 CG A:GLN96 3.8 13.0 1.0 CB A:TYR128 3.8 17.2 1.0 CD1 A:TYR128 3.8 17.7 1.0 C A:TYR128 4.0 14.4 1.0 CD A:GLN96 4.1 15.2 1.0 CA A:SER129 4.1 13.7 0.1 CZ A:TYR171 4.2 16.4 1.0 CA A:SER129 4.2 13.0 0.8 CE2 A:TYR171 4.2 13.3 1.0 C4' P:DG10 4.2 16.3 1.0 CG A:TYR128 4.3 20.7 1.0 O3' P:DG9 4.6 20.3 1.0 CG A:LYS98 4.7 14.6 1.0 NZ A:LYS98 4.7 19.2 1.0 O4' P:DG10 4.8 17.4 1.0 OP1 P:DG10 4.8 21.0 1.0 OG A:SER129 4.8 15.6 0.8 CD A:LYS98 4.8 14.4 1.0 O5' P:DG10 4.9 18.8 1.0 CE1 A:TYR128 4.9 17.9 1.0 O A:GLY127 5.0 17.0 1.0

M.S.Fairlamb, A.M.Whitaker, B.D.Freudenthal. Apurinic/Apyrimidinic (Ap) Endonuclease 1 Processing of Ap Sites with 5' Mismatches. Acta Crystallogr D Struct V. 74 760 2018BIOL.
ISSN: ISSN 2059-7983
PubMed: 30082511
DOI: 10.1107/S2059798318003340