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Chlorine in PDB 6chq: Phosphopantetheine Adenylyltransferase (Coad) in Complex with 2- Benzyl-N-(3-Chloro-4-Methylphenyl)-5-Methyl-[1,2,4]Triazolo[1,5- A]Pyrimidin-7-AmineEnzymatic activity of Phosphopantetheine Adenylyltransferase (Coad) in Complex with 2- Benzyl-N-(3-Chloro-4-Methylphenyl)-5-Methyl-[1,2,4]Triazolo[1,5- A]Pyrimidin-7-Amine
All present enzymatic activity of Phosphopantetheine Adenylyltransferase (Coad) in Complex with 2- Benzyl-N-(3-Chloro-4-Methylphenyl)-5-Methyl-[1,2,4]Triazolo[1,5- A]Pyrimidin-7-Amine:
2.7.7.3; Protein crystallography data
The structure of Phosphopantetheine Adenylyltransferase (Coad) in Complex with 2- Benzyl-N-(3-Chloro-4-Methylphenyl)-5-Methyl-[1,2,4]Triazolo[1,5- A]Pyrimidin-7-Amine, PDB code: 6chq
was solved by
M.Mamo,
B.A.Appleton,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Phosphopantetheine Adenylyltransferase (Coad) in Complex with 2- Benzyl-N-(3-Chloro-4-Methylphenyl)-5-Methyl-[1,2,4]Triazolo[1,5- A]Pyrimidin-7-Amine
(pdb code 6chq). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Phosphopantetheine Adenylyltransferase (Coad) in Complex with 2- Benzyl-N-(3-Chloro-4-Methylphenyl)-5-Methyl-[1,2,4]Triazolo[1,5- A]Pyrimidin-7-Amine, PDB code: 6chq: Chlorine binding site 1 out of 1 in 6chqGo back to Chlorine Binding Sites List in 6chq
Chlorine binding site 1 out
of 1 in the Phosphopantetheine Adenylyltransferase (Coad) in Complex with 2- Benzyl-N-(3-Chloro-4-Methylphenyl)-5-Methyl-[1,2,4]Triazolo[1,5- A]Pyrimidin-7-Amine
Mono view Stereo pair view
Reference:
C.K.Skepper,
R.J.Moreau,
B.A.Appleton,
B.M.Benton,
J.E.Drumm,
B.Y.Feng,
M.Geng,
C.Hu,
C.Li,
A.Lingel,
Y.Lu,
M.Mamo,
W.Mergo,
M.Mostafavi,
C.M.Rath,
M.Steffek,
K.T.Takeoka,
K.Uehara,
L.Wang,
J.R.Wei,
L.Xie,
W.Xu,
Q.Zhang,
J.De Vicente.
Discovery and Optimization of Phosphopantetheine Adenylyltransferase Inhibitors with Gram-Negative Antibacterial Activity. J. Med. Chem. V. 61 3325 2018.
Page generated: Sat Dec 12 12:49:38 2020
ISSN: ISSN 1520-4804 PubMed: 29551072 DOI: 10.1021/ACS.JMEDCHEM.7B01861 |
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