Chlorine in PDB 6ck2: Insulin Analog Containing A YB26W Mutation

The structure of Insulin Analog Containing A YB26W Mutation, PDB code: 6ck2 was solved by N.K.Rege, V.C.Yee, M.A.Weiss, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	33.03 / 2.25
Space group	H 3
Cell size a, b, c (Å), α, β, γ (°)	79.755, 79.755, 37.610, 90.00, 90.00, 120.00
R / Rfree (%)	20.7 / 24.7

The structure of Insulin Analog Containing A YB26W Mutation also contains other interesting chemical elements:

Zinc

(Zn)

2 atoms

The binding sites of Chlorine atom in the Insulin Analog Containing A YB26W Mutation (pdb code 6ck2). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Insulin Analog Containing A YB26W Mutation, PDB code: 6ck2:

Chlorine binding site 1 out of 1 in the Insulin Analog Containing A YB26W Mutation


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Insulin Analog Containing A YB26W Mutation within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl102 b:13.2 occ:0.33 ZN D:ZN101 2.3 17.5 0.3 NE2 D:HIS10 3.6 14.5 1.0 CB D:LEU6 3.9 20.5 1.0 CD1 D:LEU6 4.1 20.7 1.0 CD2 D:HIS10 4.1 14.2 1.0 CG D:LEU6 4.6 20.5 1.0 CE1 D:HIS10 4.7 15.5 1.0

N.K.Rege, N.P.Wickramasinghe, A.N.Tustan, N.F.B.Phillips, V.C.Yee, F.Ismail-Beigi, M.A.Weiss. Structure-Based Stabilization of Insulin As A Therapeutic Protein Assembly Via Enhanced Aromatic-Aromatic Interactions. J. Biol. Chem. V. 293 10895 2018.
ISSN: ESSN 1083-351X
PubMed: 29880646
DOI: 10.1074/JBC.RA118.003650