Chlorine in PDB 6dco: Bcl-Xl Complex with Beclin 1 BH3 Domain T108D

The structure of Bcl-Xl Complex with Beclin 1 BH3 Domain T108D, PDB code: 6dco was solved by E.F.Lee, B.J.Smith, N.A.Smith, S.Yao, W.D.Fairlie, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.92 / 2.20
Space group	P 4 21 2
Cell size a, b, c (Å), α, β, γ (°)	109.386, 109.386, 96.963, 90.00, 90.00, 90.00
R / Rfree (%)	20.3 / 23.1

The binding sites of Chlorine atom in the Bcl-Xl Complex with Beclin 1 BH3 Domain T108D (pdb code 6dco). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Bcl-Xl Complex with Beclin 1 BH3 Domain T108D, PDB code: 6dco:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in the Bcl-Xl Complex with Beclin 1 BH3 Domain T108D


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Bcl-Xl Complex with Beclin 1 BH3 Domain T108D within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl301 b:74.4 occ:1.00 NZ A:LYS87 3.3 53.2 1.0 NE1 A:TRP24 3.5 39.0 1.0 CD A:LYS87 4.0 45.0 1.0 CE A:LYS87 4.0 54.5 1.0 CZ2 A:TRP24 4.1 45.3 1.0 CE2 A:TRP24 4.1 40.8 1.0 N A:ALA84 4.1 44.7 1.0 OG A:SER25 4.2 55.4 1.0 CA A:ALA84 4.2 44.4 1.0 CG A:MET83 4.2 78.0 1.0 CB A:ALA84 4.3 40.5 1.0 CB A:MET83 4.4 59.1 1.0 C A:MET83 4.6 50.7 1.0 CD1 A:TRP24 4.6 52.2 1.0

Chlorine binding site 2 out of 3 in the Bcl-Xl Complex with Beclin 1 BH3 Domain T108D


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Bcl-Xl Complex with Beclin 1 BH3 Domain T108D within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl302 b:68.3 occ:1.00 O A:SER14 3.3 46.8 1.0 C A:SER14 3.4 44.6 1.0 OG A:SER18 3.4 61.5 1.0 N A:TYR15 3.6 43.5 1.0 CB A:SER14 3.6 39.8 1.0 NH1 A:ARG91 3.6 55.8 1.0 NH2 A:ARG91 3.6 60.6 1.0 CA A:TYR15 3.8 43.1 1.0 CZ A:ARG91 3.9 52.0 1.0 CA A:SER14 4.1 45.4 1.0 CH2 A:TRP24 4.3 43.8 1.0 CB A:SER18 4.4 52.5 1.0 CB A:TYR15 4.6 47.1 1.0 OG A:SER14 4.8 51.7 1.0 C A:TYR15 4.9 49.2 1.0 O A:ASP11 4.9 41.8 1.0 CZ2 A:TRP24 5.0 45.3 1.0

Chlorine binding site 3 out of 3 in the Bcl-Xl Complex with Beclin 1 BH3 Domain T108D


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Bcl-Xl Complex with Beclin 1 BH3 Domain T108D within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl303 b:44.1 occ:1.00 OG A:SER4 3.0 45.0 1.0 O A:MET1 3.3 93.1 1.0 N A:SER4 3.5 39.6 1.0 CA A:SER2 3.6 50.3 1.0 CB A:SER4 3.6 41.8 1.0 N A:GLN3 3.6 45.7 1.0 C A:SER2 3.8 49.8 1.0 CB A:GLU7 3.9 36.0 1.0 C A:MET1 4.2 78.2 1.0 CA A:SER4 4.2 41.9 1.0 N A:SER2 4.4 60.9 1.0 CB A:SER2 4.5 43.8 1.0 C A:GLN3 4.6 45.7 1.0 O A:SER2 4.6 59.0 1.0 CG A:GLU7 4.6 50.0 1.0 OG A:SER2 4.7 47.8 1.0 CA A:GLN3 4.7 42.6 1.0

E.F.Lee, N.A.Smith, T.P.Soares Da Costa, N.Meftahi, S.Yao, T.J.Harris, S.Tran, A.Pettikiriarachchi, M.A.Perugini, D.W.Keizer, M.Evangelista, B.J.Smith, W.D.Fairlie. Structural Insights Into BCL2 Pro-Survival Protein Interactions with the Key Autophagy Regulator BECN1 Following Phosphorylation By STK4/MST1. Autophagy V. 15 785 2019.
ISSN: ESSN 1554-8635
PubMed: 30626284
DOI: 10.1080/15548627.2018.1564557