Chlorine in PDB 6dxw: Human N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) Precursor (C126A)

All present enzymatic activity of Human N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) Precursor (C126A):
3.5.1.60;

The structure of Human N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) Precursor (C126A), PDB code: 6dxw was solved by A.Gorelik, A.Gebai, K.Illes, D.Piomelli, B.Nagar, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	38.26 / 2.30
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	87.909, 140.011, 90.123, 90.00, 115.20, 90.00
R / Rfree (%)	16.7 / 19.3

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 20; Page 3, Binding sites: 21 - 28;

Binding sites:

The binding sites of Chlorine atom in the Human N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) Precursor (C126A) (pdb code 6dxw). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 28 binding sites of Chlorine where determined in the Human N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) Precursor (C126A), PDB code: 6dxw:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Chlorine binding site 1 out of 28 in the Human N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) Precursor (C126A)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) Precursor (C126A) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl404 b:26.8 occ:1.00 HG1 A:THR286 2.1 27.9 1.0 HE A:ARG301 2.4 30.1 1.0 H A:THR286 2.4 22.8 1.0 HH21 A:ARG301 2.5 31.9 1.0 OG1 A:THR286 2.9 23.2 1.0 H A:TYR288 3.0 24.2 1.0 HB2 A:TYR288 3.1 28.7 1.0 NE A:ARG301 3.2 25.1 1.0 N A:THR286 3.3 19.0 1.0 O A:HOH560 3.3 27.2 1.0 HB2 A:ARG301 3.3 36.7 1.0 NH2 A:ARG301 3.3 26.6 1.0 O A:TYR288 3.3 19.5 1.0 HD2 A:TYR288 3.5 28.1 1.0 OE2 A:GLU285 3.5 15.9 1.0 HA A:GLU285 3.5 24.2 1.0 HG23 A:THR286 3.6 25.4 1.0 H A:ASN287 3.6 31.6 1.0 CZ A:ARG301 3.7 28.5 1.0 N A:TYR288 3.7 20.2 1.0 CB A:THR286 3.8 17.9 1.0 HG3 A:ARG301 3.9 33.9 1.0 CA A:THR286 3.9 17.7 1.0 CB A:TYR288 3.9 23.9 1.0 C A:TYR288 4.0 19.5 1.0 HH22 A:ARG301 4.0 31.9 1.0 N A:ASN287 4.0 26.4 1.0 CA A:TYR288 4.1 16.4 1.0 CD A:GLU285 4.1 17.4 1.0 CG2 A:THR286 4.1 21.2 1.0 CB A:ARG301 4.2 30.6 1.0 C A:GLU285 4.2 21.1 1.0 C A:THR286 4.3 16.1 1.0 CD2 A:TYR288 4.3 23.4 1.0 CG A:ARG301 4.3 28.2 1.0 CD A:ARG301 4.3 23.3 1.0 CA A:GLU285 4.3 20.2 1.0 HA A:HIS290 4.5 29.4 1.0 HG21 A:THR286 4.5 25.4 1.0 OE1 A:GLU285 4.5 20.8 1.0 HB2 A:ALA294 4.5 44.9 1.0 HB3 A:ARG301 4.6 36.7 1.0 CG A:TYR288 4.6 24.2 1.0 HB A:THR286 4.7 21.5 1.0 HB3 A:TYR288 4.7 28.7 1.0 C A:ASN287 4.8 20.3 1.0 O A:HOH570 4.8 31.4 1.0 HD3 A:ARG301 4.8 28.0 1.0 HA A:THR286 4.8 21.3 1.0 HD2 A:ARG301 4.9 28.0 1.0 HG22 A:THR286 5.0 25.4 1.0 HG12 A:VAL284 5.0 30.7 1.0 HG3 A:GLU285 5.0 18.6 1.0

Chlorine binding site 2 out of 28 in the Human N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) Precursor (C126A)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Human N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) Precursor (C126A) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl405 b:35.4 occ:1.00 HE A:ARG221 2.5 27.5 1.0 HH21 A:ARG221 2.6 29.9 1.0 HZ A:PHE169 3.0 27.0 1.0 NE A:ARG221 3.3 22.9 1.0 HG A:SER225 3.3 52.1 1.0 NH2 A:ARG221 3.3 25.0 1.0 HB2 A:SER225 3.3 30.8 1.0 O A:HOH721 3.4 41.8 1.0 HG2 A:ARG221 3.6 35.8 1.0 HD22 A:LEU40 3.7 35.4 1.0 CZ A:ARG221 3.7 24.5 1.0 HD13 A:LEU40 3.8 33.1 1.0 CZ A:PHE169 3.8 22.5 1.0 HD21 A:LEU40 3.9 35.4 1.0 OG A:SER225 3.9 43.4 1.0 HG3 A:PRO94 3.9 50.0 1.0 HD11 A:LEU40 3.9 33.1 1.0 CB A:SER225 4.0 25.7 1.0 HE2 A:PHE169 4.0 29.6 1.0 HH22 A:ARG221 4.0 29.9 1.0 HB3 A:SER225 4.2 30.8 1.0 HG2 A:PRO94 4.2 50.0 1.0 CD2 A:LEU40 4.2 29.5 1.0 CD1 A:LEU40 4.3 27.6 1.0 CE2 A:PHE169 4.3 24.6 1.0 CG A:ARG221 4.4 29.8 1.0 CD A:ARG221 4.4 23.3 1.0 CG A:PRO94 4.4 41.7 1.0 HH12 A:ARG47 4.5 37.1 1.0 HD2 A:PRO94 4.5 47.6 1.0 HG3 A:ARG221 4.7 35.8 1.0 HD3 A:ARG221 4.8 27.9 1.0 CD A:PRO94 4.9 39.6 1.0 HD3 A:PRO94 4.9 47.6 1.0 HA A:ALA222 4.9 29.8 1.0 CE1 A:PHE169 4.9 24.9 1.0 CG A:LEU40 4.9 34.6 1.0 NH1 A:ARG47 4.9 30.9 1.0 O A:ARG221 5.0 25.8 1.0 HH11 A:ARG47 5.0 37.1 1.0 HE1 A:PHE169 5.0 29.8 1.0 HD23 A:LEU40 5.0 35.4 1.0

Chlorine binding site 3 out of 28 in the Human N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) Precursor (C126A)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Human N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) Precursor (C126A) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl406 b:40.8 occ:1.00 H A:LEU318 2.3 32.5 1.0 HE1 A:TYR139 2.8 36.0 1.0 O A:HOH633 2.9 40.9 1.0 HB2 A:SER317 2.9 37.0 1.0 HZ2 A:LYS348 2.9 95.0 1.0 HG A:LEU318 3.0 34.8 1.0 HB2 A:LEU318 3.1 31.0 1.0 N A:LEU318 3.2 27.1 1.0 HA A:SER317 3.6 36.1 1.0 HZ3 A:LYS348 3.7 95.0 1.0 CB A:LEU318 3.7 25.8 1.0 NZ A:LYS348 3.7 79.2 1.0 CG A:LEU318 3.7 29.0 1.0 CE1 A:TYR139 3.7 30.0 1.0 HD12 A:LEU318 3.8 45.2 1.0 CB A:SER317 3.8 30.8 1.0 HD2 A:LYS348 3.8 67.1 1.0 CA A:SER317 4.0 30.1 1.0 O A:HOH652 4.0 55.2 1.0 CA A:LEU318 4.0 25.3 1.0 O A:HOH683 4.1 63.7 1.0 HD1 A:TYR139 4.1 29.7 1.0 H A:GLU319 4.1 37.1 1.0 C A:SER317 4.1 28.6 1.0 HD3 A:LYS348 4.2 67.1 1.0 HZ1 A:LYS348 4.3 95.0 1.0 CD1 A:LEU318 4.3 37.6 1.0 HB3 A:SER317 4.3 37.0 1.0 CD1 A:TYR139 4.4 24.8 1.0 CD A:LYS348 4.4 55.9 1.0 HB3 A:LEU318 4.6 31.0 1.0 CE A:LYS348 4.6 68.8 1.0 HD11 A:LEU318 4.6 45.2 1.0 HA A:LEU318 4.7 30.3 1.0 CZ A:TYR139 4.7 29.9 1.0 OG A:SER317 4.7 30.9 1.0 N A:GLU319 4.8 30.9 1.0 OH A:TYR139 4.8 38.6 1.0 HE3 A:LYS348 4.9 82.5 1.0 HG A:SER317 4.9 37.1 1.0 C A:LEU318 5.0 23.8 1.0

Chlorine binding site 4 out of 28 in the Human N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) Precursor (C126A)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Human N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) Precursor (C126A) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl407 b:46.6 occ:1.00 HE A:ARG256 2.3 39.7 1.0 HE22 A:GLN132 2.4 23.6 1.0 O B:HOH615 2.8 29.3 1.0 O A:HOH719 3.0 24.1 1.0 HH21 A:ARG256 3.1 42.4 1.0 NE2 A:GLN132 3.2 19.6 1.0 NE A:ARG256 3.2 33.1 1.0 HG3 A:ARG256 3.2 29.7 1.0 HG2 A:PRO276 3.3 34.1 1.0 HB2 A:PRO276 3.5 28.8 1.0 HE21 A:GLN132 3.5 23.6 1.0 HB3 A:PRO255 3.6 25.5 1.0 HD2 B:LYS198 3.6 35.6 1.0 HZ3 B:LYS198 3.7 48.9 1.0 HG2 A:ARG256 3.7 29.7 1.0 NH2 A:ARG256 3.7 35.4 1.0 HE2 B:LYS198 3.8 41.7 1.0 CG A:ARG256 3.8 24.8 1.0 O A:HOH716 3.9 29.6 1.0 CZ A:ARG256 3.9 36.8 1.0 HB2 A:PRO255 4.0 25.5 1.0 CB A:PRO276 4.1 24.0 1.0 CG A:PRO276 4.1 28.4 1.0 CD A:ARG256 4.1 27.7 1.0 HB3 A:PRO276 4.2 28.8 1.0 CD A:GLN132 4.2 17.9 1.0 CB A:PRO255 4.2 21.2 1.0 CE B:LYS198 4.3 34.7 1.0 OE1 A:GLN132 4.3 26.3 1.0 O A:HOH585 4.3 30.0 1.0 CD B:LYS198 4.4 29.7 1.0 NZ B:LYS198 4.4 40.7 1.0 O A:HOH664 4.5 18.8 1.0 HH22 A:ARG256 4.5 42.4 1.0 HG3 A:PRO276 4.7 34.1 1.0 HD3 B:LYS198 4.7 35.6 1.0 HD2 A:ARG256 4.7 33.2 1.0 HZ1 B:LYS198 4.7 48.9 1.0 HD3 A:ARG256 4.7 33.2 1.0 HD2 A:PRO276 4.8 26.8 1.0 O B:HOH540 4.8 21.8 1.0 HA2 A:GLY136 4.9 24.7 1.0

Chlorine binding site 5 out of 28 in the Human N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) Precursor (C126A)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Human N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) Precursor (C126A) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl408 b:57.5 occ:1.00 HZ1 A:LYS236 2.6 39.2 1.0 O A:HOH516 2.8 38.5 1.0 O A:HOH733 2.9 44.5 1.0 HD13 A:ILE214 3.0 40.0 1.0 O A:HOH735 3.2 39.1 1.0 HB1 A:ALA222 3.3 28.5 1.0 NZ A:LYS236 3.3 32.6 1.0 HG21 A:THR240 3.4 24.2 1.0 HZ2 A:LYS236 3.4 39.2 1.0 HB3 A:ALA222 3.4 28.5 1.0 HE3 A:LYS236 3.5 34.6 1.0 HD11 A:ILE214 3.5 40.0 1.0 HD13 A:LEU219 3.5 25.7 1.0 HD12 A:LEU219 3.6 25.7 1.0 CD1 A:ILE214 3.6 33.3 1.0 CB A:ALA222 3.7 23.8 1.0 HB2 A:ALA222 3.8 28.5 1.0 CE A:LYS236 3.9 28.9 1.0 HD12 A:ILE214 3.9 40.0 1.0 O A:HOH527 4.0 31.1 1.0 CD1 A:LEU219 4.0 21.4 1.0 HZ3 A:LYS236 4.0 39.2 1.0 O A:HOH746 4.1 45.4 1.0 HE2 A:LYS236 4.1 34.6 1.0 CG2 A:THR240 4.3 20.1 1.0 HA A:LEU219 4.3 22.4 1.0 HD11 A:LEU219 4.3 25.7 1.0 HG23 A:THR240 4.4 24.2 1.0 HG21 A:ILE214 4.5 46.9 1.0 HG1 A:THR240 4.5 24.0 1.0 HG22 A:THR240 4.7 24.2 1.0 OE2 A:GLU226 4.8 65.1 1.0 CG1 A:ILE214 5.0 26.9 1.0

Chlorine binding site 6 out of 28 in the Human N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) Precursor (C126A)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Human N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) Precursor (C126A) within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl405 b:25.3 occ:1.00 HG1 B:THR286 2.0 27.9 1.0 HE B:ARG301 2.3 25.9 1.0 H B:THR286 2.4 19.4 1.0 HH21 B:ARG301 2.6 28.8 1.0 OG1 B:THR286 2.8 23.3 1.0 H B:TYR288 2.9 25.7 1.0 HB2 B:TYR288 3.1 29.3 1.0 O B:HOH567 3.1 24.2 1.0 NE B:ARG301 3.1 21.6 1.0 N B:THR286 3.3 16.1 1.0 HB2 B:ARG301 3.3 38.1 1.0 NH2 B:ARG301 3.3 24.0 1.0 O B:TYR288 3.4 22.6 1.0 HD2 B:TYR288 3.4 31.8 1.0 HG23 B:THR286 3.5 36.6 1.0 OE2 B:GLU285 3.5 22.6 1.0 HA B:GLU285 3.6 19.6 1.0 H B:ASN287 3.6 22.5 1.0 N B:TYR288 3.7 21.4 1.0 CZ B:ARG301 3.7 25.2 1.0 CB B:THR286 3.8 22.2 1.0 HG3 B:ARG301 3.8 35.7 1.0 CB B:TYR288 3.9 24.4 1.0 CA B:THR286 3.9 17.5 1.0 C B:TYR288 4.0 24.4 1.0 N B:ASN287 4.0 18.8 1.0 CA B:TYR288 4.0 21.7 1.0 HH22 B:ARG301 4.1 28.8 1.0 CG2 B:THR286 4.1 30.5 1.0 CB B:ARG301 4.1 31.7 1.0 CD B:GLU285 4.2 22.6 1.0 CD2 B:TYR288 4.2 26.5 1.0 HB2 B:ALA294 4.2 41.4 1.0 CD B:ARG301 4.3 27.9 1.0 CG B:ARG301 4.3 29.7 1.0 C B:THR286 4.3 16.9 1.0 C B:GLU285 4.3 18.7 1.0 CA B:GLU285 4.4 16.4 1.0 HG21 B:THR286 4.4 36.6 1.0 HB3 B:ARG301 4.5 38.1 1.0 CG B:TYR288 4.6 26.4 1.0 OE1 B:GLU285 4.6 15.8 1.0 HA B:HIS290 4.6 29.6 1.0 HB B:THR286 4.6 26.7 1.0 HB3 B:TYR288 4.6 29.3 1.0 O B:HOH556 4.7 25.6 1.0 C B:ASN287 4.8 27.5 1.0 HD3 B:ARG301 4.8 33.5 1.0 HA B:THR286 4.9 21.0 1.0 HD2 B:ARG301 4.9 33.5 1.0 HG22 B:THR286 4.9 36.6 1.0 HG12 B:VAL284 4.9 20.5 1.0

Chlorine binding site 7 out of 28 in the Human N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) Precursor (C126A)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 7 of Human N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) Precursor (C126A) within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl406 b:40.5 occ:1.00 HE B:ARG221 2.5 33.7 1.0 HH21 B:ARG221 2.6 39.1 1.0 HZ B:PHE169 3.0 31.7 1.0 HG B:SER225 3.0 48.5 1.0 HB2 B:SER225 3.2 33.1 1.0 NE B:ARG221 3.3 28.1 1.0 NH2 B:ARG221 3.3 32.6 1.0 HD22 B:LEU40 3.6 40.5 1.0 OG B:SER225 3.6 40.4 1.0 HG2 B:ARG221 3.7 30.6 1.0 HD13 B:LEU40 3.7 46.7 1.0 HG3 B:PRO94 3.8 50.4 1.0 CZ B:ARG221 3.8 30.2 1.0 O B:HOH707 3.8 47.1 1.0 CB B:SER225 3.8 27.6 1.0 CZ B:PHE169 3.8 26.4 1.0 HD21 B:LEU40 3.9 40.5 1.0 HD11 B:LEU40 3.9 46.7 1.0 HE2 B:PHE169 3.9 35.6 1.0 HH22 B:ARG221 4.0 39.1 1.0 HB3 B:SER225 4.1 33.1 1.0 CD2 B:LEU40 4.2 33.7 1.0 HG2 B:PRO94 4.2 50.4 1.0 CD1 B:LEU40 4.2 38.9 1.0 CE2 B:PHE169 4.3 29.7 1.0 CG B:PRO94 4.4 42.0 1.0 CG B:ARG221 4.4 25.5 1.0 CD B:ARG221 4.4 28.1 1.0 HD2 B:PRO94 4.6 49.1 1.0 HH12 B:ARG47 4.7 43.5 1.0 HG3 B:ARG221 4.7 30.6 1.0 CG B:LEU40 4.9 39.6 1.0 HD3 B:ARG221 4.9 33.7 1.0 CD B:PRO94 4.9 40.9 1.0 CE1 B:PHE169 4.9 23.0 1.0 HD3 B:PRO94 4.9 49.1 1.0 HD23 B:LEU40 4.9 40.5 1.0 HA B:ALA222 5.0 29.3 1.0

Chlorine binding site 8 out of 28 in the Human N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) Precursor (C126A)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 8 of Human N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) Precursor (C126A) within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl407 b:47.7 occ:1.00 HZ3 B:LYS348 2.4 0.1 1.0 H B:LEU318 2.5 37.2 1.0 HE1 B:TYR139 2.9 40.3 1.0 HG B:LEU318 3.1 41.8 1.0 HB2 B:SER317 3.1 39.6 1.0 HB2 B:LEU318 3.1 39.3 1.0 NZ B:LYS348 3.2 0.1 1.0 HZ2 B:LYS348 3.2 0.1 1.0 O B:HOH616 3.4 44.1 1.0 N B:LEU318 3.4 31.0 1.0 HD3 B:LYS348 3.5 0.3 1.0 HZ1 B:LYS348 3.7 0.1 1.0 HD12 B:LEU318 3.7 45.1 1.0 CE1 B:TYR139 3.7 33.6 1.0 CB B:LEU318 3.8 32.8 1.0 CG B:LEU318 3.8 34.8 1.0 HA B:SER317 3.8 34.6 1.0 O B:HOH708 3.8 58.4 1.0 CB B:SER317 4.0 33.0 1.0 CD B:LYS348 4.2 89.4 1.0 CA B:LEU318 4.2 36.7 1.0 CE B:LYS348 4.2 0.2 1.0 CA B:SER317 4.2 28.8 1.0 CD1 B:LEU318 4.3 37.6 1.0 O B:HOH543 4.3 52.2 1.0 H B:GLU319 4.3 36.5 1.0 HD2 B:LYS348 4.3 0.3 1.0 C B:SER317 4.3 28.9 1.0 OH B:TYR139 4.3 43.3 1.0 HB3 B:SER317 4.4 39.6 1.0 HD1 B:TYR139 4.5 40.8 1.0 CZ B:TYR139 4.5 30.6 1.0 HE2 B:LYS348 4.5 0.8 1.0 CD1 B:TYR139 4.5 34.0 1.0 HD11 B:LEU318 4.6 45.1 1.0 HB3 B:LEU318 4.6 39.3 1.0 HA B:LEU318 4.9 44.0 1.0 OG B:SER317 4.9 40.4 1.0 N B:GLU319 5.0 30.4 1.0 HE3 B:LYS348 5.0 0.8 1.0

Chlorine binding site 9 out of 28 in the Human N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) Precursor (C126A)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 9 of Human N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) Precursor (C126A) within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl408 b:58.7 occ:1.00 HD23 A:LEU277 2.7 43.5 1.0 HH12 B:ARG265 2.8 37.1 1.0 O A:HOH712 3.0 41.4 1.0 O B:HOH531 3.0 34.9 1.0 O B:HOH615 3.1 29.3 1.0 HA A:LEU277 3.2 30.6 1.0 O B:HOH537 3.3 25.5 1.0 NH1 B:ARG265 3.5 30.9 1.0 O B:HOH528 3.6 32.5 1.0 HB3 B:LYS198 3.6 37.0 1.0 CD2 A:LEU277 3.6 36.3 1.0 HH11 B:ARG265 3.8 37.1 1.0 HG3 B:LYS198 3.9 32.5 1.0 HD21 A:LEU277 3.9 43.5 1.0 HB2 B:LYS198 3.9 37.0 1.0 HZ3 B:LYS198 4.0 48.9 1.0 HD22 A:LEU277 4.0 43.5 1.0 HZ2 B:LYS198 4.1 48.9 1.0 CA A:LEU277 4.1 25.5 1.0 HD22 B:ASN204 4.1 27.7 1.0 CB B:LYS198 4.2 30.9 1.0 HH22 B:ARG265 4.2 37.3 1.0 O B:HOH530 4.2 41.4 1.0 O A:PRO276 4.3 32.0 1.0 HD2 B:LYS198 4.4 35.6 1.0 HD21 B:ASN204 4.4 27.7 1.0 CG B:LYS198 4.4 27.1 1.0 NZ B:LYS198 4.5 40.7 1.0 N A:LEU277 4.5 24.0 1.0 ND2 B:ASN204 4.5 23.1 1.0 CZ B:ARG265 4.5 33.0 1.0 C A:PRO276 4.6 31.9 1.0 HG A:LEU277 4.6 42.2 1.0 HB2 A:PRO276 4.6 28.8 1.0 CG A:LEU277 4.6 35.2 1.0 NH2 B:ARG265 4.7 31.1 1.0 OD1 B:ASP245 4.7 38.4 1.0 CD B:LYS198 4.9 29.7 1.0 O B:HOH688 4.9 44.8 1.0 CB A:LEU277 4.9 33.6 1.0 HH21 A:ARG256 4.9 42.4 1.0 H A:LEU277 5.0 28.8 1.0

Chlorine binding site 10 out of 28 in the Human N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) Precursor (C126A)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 10 of Human N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) Precursor (C126A) within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl409 b:55.8 occ:1.00 HH22 B:ARG256 3.0 42.4 1.0 HG2 B:PRO255 3.1 40.0 1.0 HH12 B:ARG256 3.4 40.4 1.0 HD2 B:PRO255 3.6 37.3 1.0 NH2 B:ARG256 3.8 35.3 1.0 HB2 B:PRO255 3.9 38.2 1.0 CG B:PRO255 4.0 33.3 1.0 O B:HOH599 4.1 54.4 1.0 NH1 B:ARG256 4.1 33.6 1.0 CD B:PRO255 4.2 31.1 1.0 HH21 B:ARG256 4.3 42.4 1.0 CZ B:ARG256 4.4 32.1 1.0 CB B:PRO255 4.4 31.8 1.0 HG3 B:PRO255 4.7 40.0 1.0 HD3 B:PRO255 4.7 37.3 1.0 HH11 B:ARG256 4.8 40.4 1.0

A.Gorelik, A.Gebai, K.Illes, D.Piomelli, B.Nagar. Molecular Mechanism of Activation of the Immunoregulatory Amidase Naaa. Proc. Natl. Acad. Sci. V. 115 10032 2018U.S.A..
ISSN: ESSN 1091-6490
PubMed: 30301806
DOI: 10.1073/PNAS.1811759115