Chlorine in PDB 6dxy: Murine N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa)
Enzymatic activity of Murine N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa)
All present enzymatic activity of Murine N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa):
3.5.1.60;
Protein crystallography data
The structure of Murine N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa), PDB code: 6dxy
was solved by
A.Gorelik,
A.Gebai,
K.Illes,
D.Piomelli,
B.Nagar,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
|
Resolution Low / High (Å)
|
40.44 /
1.85
|
|
Space group
|
H 3
|
|
Cell size a, b, c (Å), α, β, γ (°)
|
202.205,
202.205,
45.596,
90.00,
90.00,
120.00
|
|
R / Rfree (%)
|
16.7 /
19.2
|
Chlorine Binding Sites:
Pages:
>>> Page 1 <<<
Page 2, Binding sites: 11 -
11;
Binding sites:
The binding sites of Chlorine atom in the Murine N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa)
(pdb code 6dxy). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 11 binding sites of Chlorine where determined in the
Murine N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa), PDB code: 6dxy:
Jump to Chlorine binding site number:
1;
2;
3;
4;
5;
6;
7;
8;
9;
10;
Chlorine binding site 1 out
of 11 in 6dxy
Go back to
Chlorine Binding Sites List in 6dxy
Chlorine binding site 1 out
of 11 in the Murine N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa)
 Mono view
 Stereo pair view
|
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Murine N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Cl202
b:50.0
occ:1.00
|
H
|
A:ASP61
|
2.2
|
35.6
|
1.0
|
|
HA
|
A:TYR60
|
2.9
|
30.6
|
1.0
|
|
N
|
A:ASP61
|
3.0
|
29.7
|
1.0
|
|
HB3
|
A:ASP61
|
3.3
|
45.0
|
1.0
|
|
HD1
|
A:TYR60
|
3.4
|
27.9
|
1.0
|
|
HB2
|
A:ASP61
|
3.4
|
45.0
|
1.0
|
|
CA
|
A:TYR60
|
3.6
|
25.5
|
1.0
|
|
HB3
|
A:TYR60
|
3.7
|
29.0
|
1.0
|
|
HD2
|
A:PHE64
|
3.7
|
42.7
|
1.0
|
|
CB
|
A:ASP61
|
3.7
|
37.5
|
1.0
|
|
O
|
A:HOH319
|
3.8
|
33.9
|
1.0
|
|
C
|
A:TYR60
|
3.8
|
27.8
|
1.0
|
|
CA
|
A:ASP61
|
3.9
|
32.4
|
1.0
|
|
HB3
|
A:PHE64
|
3.9
|
41.1
|
1.0
|
|
O
|
B:HOH647
|
4.0
|
47.4
|
1.0
|
|
CB
|
A:TYR60
|
4.1
|
24.1
|
1.0
|
|
CD1
|
A:TYR60
|
4.1
|
23.3
|
1.0
|
|
CD2
|
A:PHE64
|
4.1
|
35.6
|
1.0
|
|
HB2
|
A:PHE64
|
4.4
|
41.1
|
1.0
|
|
O
|
A:HIS59
|
4.5
|
25.1
|
1.0
|
|
CB
|
A:PHE64
|
4.5
|
34.3
|
1.0
|
|
CG
|
A:TYR60
|
4.5
|
22.6
|
1.0
|
|
CG
|
A:PHE64
|
4.6
|
34.0
|
1.0
|
|
HA
|
A:ASP61
|
4.6
|
38.9
|
1.0
|
|
O
|
A:ASP61
|
4.7
|
31.6
|
1.0
|
|
CE2
|
A:PHE64
|
4.8
|
39.2
|
1.0
|
|
N
|
A:TYR60
|
4.9
|
24.5
|
1.0
|
|
O
|
B:HOH638
|
4.9
|
64.6
|
1.0
|
|
C
|
A:ASP61
|
4.9
|
32.2
|
1.0
|
|
HE2
|
A:PHE64
|
4.9
|
47.0
|
1.0
|
|
HB2
|
A:TYR60
|
5.0
|
29.0
|
1.0
|
|
Chlorine binding site 2 out
of 11 in 6dxy
Go back to
Chlorine Binding Sites List in 6dxy
Chlorine binding site 2 out
of 11 in the Murine N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa)
 Mono view
 Stereo pair view
|
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Murine N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Cl402
b:15.1
occ:1.00
|
HG1
|
B:THR291
|
2.2
|
17.2
|
1.0
|
|
HE
|
B:ARG306
|
2.4
|
20.7
|
1.0
|
|
H
|
B:THR291
|
2.4
|
14.3
|
1.0
|
|
HH21
|
B:ARG306
|
2.5
|
22.2
|
1.0
|
|
H
|
B:TYR293
|
3.0
|
19.4
|
1.0
|
|
OG1
|
B:THR291
|
3.0
|
14.3
|
1.0
|
|
O
|
B:HOH523
|
3.1
|
31.3
|
1.0
|
|
HB2
|
B:TYR293
|
3.2
|
22.5
|
1.0
|
|
NE
|
B:ARG306
|
3.2
|
17.2
|
1.0
|
|
N
|
B:THR291
|
3.3
|
11.9
|
1.0
|
|
O
|
B:TYR293
|
3.3
|
16.1
|
1.0
|
|
HB2
|
B:ARG306
|
3.3
|
19.3
|
1.0
|
|
NH2
|
B:ARG306
|
3.3
|
18.5
|
1.0
|
|
OE2
|
B:GLU290
|
3.5
|
13.4
|
1.0
|
|
HA
|
B:GLU290
|
3.5
|
13.6
|
1.0
|
|
HG23
|
B:THR291
|
3.6
|
15.4
|
1.0
|
|
HD2
|
B:TYR293
|
3.6
|
21.8
|
1.0
|
|
H
|
B:ASN292
|
3.7
|
16.6
|
1.0
|
|
CZ
|
B:ARG306
|
3.7
|
18.5
|
1.0
|
|
N
|
B:TYR293
|
3.7
|
16.1
|
1.0
|
|
HG3
|
B:ARG306
|
3.9
|
19.3
|
1.0
|
|
CB
|
B:THR291
|
3.9
|
13.0
|
1.0
|
|
C
|
B:TYR293
|
4.0
|
17.4
|
1.0
|
|
CA
|
B:THR291
|
4.0
|
12.1
|
1.0
|
|
CB
|
B:TYR293
|
4.0
|
18.7
|
1.0
|
|
HH22
|
B:ARG306
|
4.0
|
22.2
|
1.0
|
|
N
|
B:ASN292
|
4.1
|
13.9
|
1.0
|
|
CA
|
B:TYR293
|
4.1
|
17.7
|
1.0
|
|
CD
|
B:GLU290
|
4.1
|
12.7
|
1.0
|
|
CB
|
B:ARG306
|
4.1
|
16.1
|
1.0
|
|
CG2
|
B:THR291
|
4.2
|
12.8
|
1.0
|
|
C
|
B:GLU290
|
4.2
|
11.1
|
1.0
|
|
CA
|
B:GLU290
|
4.3
|
11.3
|
1.0
|
|
CG
|
B:ARG306
|
4.3
|
16.1
|
1.0
|
|
HA
|
B:HIS295
|
4.3
|
21.4
|
1.0
|
|
C
|
B:THR291
|
4.3
|
12.6
|
1.0
|
|
CD
|
B:ARG306
|
4.3
|
17.4
|
1.0
|
|
CD2
|
B:TYR293
|
4.4
|
18.2
|
1.0
|
|
HB2
|
B:ALA299
|
4.5
|
31.5
|
1.0
|
|
OE1
|
B:GLU290
|
4.5
|
13.2
|
1.0
|
|
HG21
|
B:THR291
|
4.5
|
15.4
|
1.0
|
|
HB3
|
B:ARG306
|
4.5
|
19.3
|
1.0
|
|
HB3
|
B:TYR293
|
4.7
|
22.5
|
1.0
|
|
CG
|
B:TYR293
|
4.7
|
19.1
|
1.0
|
|
O
|
B:HOH545
|
4.8
|
16.1
|
1.0
|
|
HB
|
B:THR291
|
4.8
|
15.7
|
1.0
|
|
O
|
B:VAL289
|
4.8
|
12.7
|
1.0
|
|
HD3
|
B:ARG306
|
4.8
|
20.9
|
1.0
|
|
C
|
B:ASN292
|
4.8
|
16.1
|
1.0
|
|
HA
|
B:THR291
|
4.9
|
14.5
|
1.0
|
|
HG12
|
B:VAL289
|
4.9
|
14.6
|
1.0
|
|
HD2
|
B:ARG306
|
4.9
|
20.9
|
1.0
|
|
Chlorine binding site 3 out
of 11 in 6dxy
Go back to
Chlorine Binding Sites List in 6dxy
Chlorine binding site 3 out
of 11 in the Murine N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa)
 Mono view
 Stereo pair view
|
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 3 of Murine N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Cl403
b:45.0
occ:1.00
|
HE
|
B:ARG226
|
2.4
|
27.4
|
1.0
|
|
HH21
|
B:ARG226
|
2.8
|
31.8
|
1.0
|
|
O
|
B:HOH552
|
3.0
|
41.8
|
1.0
|
|
O
|
A:HOH349
|
3.0
|
52.6
|
1.0
|
|
NE
|
B:ARG226
|
3.2
|
22.9
|
1.0
|
|
HG2
|
B:ARG226
|
3.2
|
23.7
|
1.0
|
|
HB2
|
B:SER230
|
3.5
|
28.6
|
1.0
|
|
HD13
|
A:LEU45
|
3.5
|
26.2
|
1.0
|
|
NH2
|
B:ARG226
|
3.5
|
26.5
|
1.0
|
|
O
|
B:HOH641
|
3.6
|
38.5
|
1.0
|
|
HD22
|
A:LEU45
|
3.7
|
24.4
|
1.0
|
|
CZ
|
B:ARG226
|
3.8
|
24.4
|
1.0
|
|
HZ
|
B:PHE174
|
3.8
|
21.1
|
1.0
|
|
HD11
|
A:LEU45
|
3.8
|
26.2
|
1.0
|
|
HB3
|
B:SER230
|
3.9
|
28.6
|
1.0
|
|
OG
|
B:SER230
|
4.0
|
26.0
|
1.0
|
|
CB
|
B:SER230
|
4.0
|
23.9
|
1.0
|
|
HD21
|
A:LEU45
|
4.0
|
24.4
|
1.0
|
|
CG
|
B:ARG226
|
4.0
|
19.7
|
1.0
|
|
HA
|
B:LYS227
|
4.0
|
25.9
|
1.0
|
|
CD1
|
A:LEU45
|
4.1
|
21.8
|
1.0
|
|
CD
|
B:ARG226
|
4.2
|
20.7
|
1.0
|
|
HH22
|
B:ARG226
|
4.2
|
31.8
|
1.0
|
|
CD2
|
A:LEU45
|
4.3
|
20.3
|
1.0
|
|
HG
|
B:SER230
|
4.3
|
31.2
|
1.0
|
|
HG3
|
B:ARG226
|
4.3
|
23.7
|
1.0
|
|
O
|
B:ARG226
|
4.6
|
19.4
|
1.0
|
|
CZ
|
B:PHE174
|
4.6
|
17.6
|
1.0
|
|
HE2
|
B:PHE174
|
4.7
|
22.2
|
1.0
|
|
HD3
|
B:ARG226
|
4.7
|
24.9
|
1.0
|
|
CG
|
A:LEU45
|
4.8
|
21.0
|
1.0
|
|
HD2
|
B:ARG226
|
4.9
|
24.9
|
1.0
|
|
HD12
|
A:LEU45
|
4.9
|
26.2
|
1.0
|
|
CA
|
B:LYS227
|
4.9
|
21.6
|
1.0
|
|
C
|
B:ARG226
|
4.9
|
18.9
|
1.0
|
|
Chlorine binding site 4 out
of 11 in 6dxy
Go back to
Chlorine Binding Sites List in 6dxy
Chlorine binding site 4 out
of 11 in the Murine N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa)
 Mono view
 Stereo pair view
|
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 4 of Murine N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Cl404
b:60.2
occ:1.00
|
H
|
B:ASP294
|
2.1
|
22.6
|
1.0
|
|
HZ1
|
B:LYS203
|
2.7
|
79.9
|
1.0
|
|
HZ2
|
B:LYS203
|
2.8
|
79.9
|
1.0
|
|
HZ3
|
B:LYS203
|
2.9
|
79.9
|
1.0
|
|
N
|
B:ASP294
|
2.9
|
18.8
|
1.0
|
|
NZ
|
B:LYS203
|
3.0
|
66.6
|
1.0
|
|
HA
|
B:TYR293
|
3.0
|
21.2
|
1.0
|
|
HB3
|
B:TYR293
|
3.0
|
22.5
|
1.0
|
|
HD2
|
B:LYS297
|
3.1
|
50.5
|
1.0
|
|
HB2
|
B:ASP294
|
3.2
|
24.9
|
1.0
|
|
HD1
|
B:TYR293
|
3.4
|
24.8
|
1.0
|
|
CA
|
B:TYR293
|
3.6
|
17.7
|
1.0
|
|
O
|
B:HOH560
|
3.6
|
44.4
|
1.0
|
|
CG
|
B:ASP294
|
3.7
|
21.1
|
1.0
|
|
CB
|
B:ASP294
|
3.7
|
20.8
|
1.0
|
|
CB
|
B:TYR293
|
3.7
|
18.7
|
1.0
|
|
C
|
B:TYR293
|
3.7
|
17.4
|
1.0
|
|
O
|
B:HOH577
|
3.8
|
49.4
|
1.0
|
|
HZ2
|
B:LYS297
|
3.8
|
53.7
|
1.0
|
|
CA
|
B:ASP294
|
3.9
|
18.9
|
1.0
|
|
OD2
|
B:ASP294
|
3.9
|
22.9
|
1.0
|
|
HH
|
B:TYR252
|
4.0
|
20.9
|
1.0
|
|
CD
|
B:LYS297
|
4.0
|
42.1
|
1.0
|
|
HB2
|
B:LYS297
|
4.0
|
31.9
|
1.0
|
|
OD1
|
B:ASP294
|
4.1
|
19.7
|
1.0
|
|
CD1
|
B:TYR293
|
4.2
|
20.7
|
1.0
|
|
HD3
|
B:LYS297
|
4.2
|
50.5
|
1.0
|
|
OH
|
B:TYR252
|
4.3
|
17.4
|
1.0
|
|
CG
|
B:TYR293
|
4.5
|
19.1
|
1.0
|
|
CE
|
B:LYS203
|
4.5
|
67.8
|
1.0
|
|
HB2
|
B:TYR293
|
4.5
|
22.5
|
1.0
|
|
NZ
|
B:LYS297
|
4.5
|
44.8
|
1.0
|
|
HZ3
|
B:LYS297
|
4.5
|
53.7
|
1.0
|
|
HA
|
B:ASP294
|
4.6
|
22.7
|
1.0
|
|
O
|
B:ASP294
|
4.6
|
19.9
|
1.0
|
|
HB3
|
B:ASP294
|
4.6
|
24.9
|
1.0
|
|
C
|
B:ASP294
|
4.8
|
18.9
|
1.0
|
|
CE
|
B:LYS297
|
4.8
|
45.0
|
1.0
|
|
CB
|
B:LYS297
|
4.8
|
26.6
|
1.0
|
|
HE3
|
B:LYS203
|
4.8
|
81.3
|
1.0
|
|
HE2
|
B:LYS203
|
4.8
|
81.3
|
1.0
|
|
CG
|
B:LYS297
|
4.9
|
40.5
|
1.0
|
|
O
|
B:TYR293
|
4.9
|
16.1
|
1.0
|
|
N
|
B:TYR293
|
5.0
|
16.1
|
1.0
|
|
O
|
B:ASN292
|
5.0
|
17.3
|
1.0
|
|
HD3
|
B:LYS203
|
5.0
|
83.7
|
1.0
|
|
Chlorine binding site 5 out
of 11 in 6dxy
Go back to
Chlorine Binding Sites List in 6dxy
Chlorine binding site 5 out
of 11 in the Murine N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa)
 Mono view
 Stereo pair view
|
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 5 of Murine N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Cl405
b:57.4
occ:1.00
|
H
|
B:LEU323
|
2.4
|
20.4
|
1.0
|
|
HB2
|
B:ASN322
|
2.6
|
25.0
|
1.0
|
|
HB2
|
B:LEU323
|
2.9
|
19.1
|
1.0
|
|
HG
|
B:LEU323
|
3.1
|
18.8
|
1.0
|
|
HZ3
|
B:LYS353
|
3.2
|
33.1
|
1.0
|
|
N
|
B:LEU323
|
3.2
|
17.0
|
1.0
|
|
HE1
|
B:TYR144
|
3.4
|
25.3
|
1.0
|
|
HD12
|
B:LEU323
|
3.5
|
19.5
|
1.0
|
|
CB
|
B:ASN322
|
3.6
|
20.8
|
1.0
|
|
CB
|
B:LEU323
|
3.6
|
15.9
|
1.0
|
|
CG
|
B:LEU323
|
3.7
|
15.7
|
1.0
|
|
HD3
|
B:LYS353
|
3.9
|
29.8
|
1.0
|
|
H
|
B:GLU324
|
4.0
|
21.0
|
1.0
|
|
CA
|
B:LEU323
|
4.0
|
15.7
|
1.0
|
|
HB3
|
B:ASN322
|
4.0
|
25.0
|
1.0
|
|
CE1
|
B:TYR144
|
4.0
|
21.1
|
1.0
|
|
NZ
|
B:LYS353
|
4.1
|
27.6
|
1.0
|
|
CD1
|
B:LEU323
|
4.1
|
16.2
|
1.0
|
|
HA
|
B:ASN322
|
4.2
|
22.6
|
1.0
|
|
C
|
B:ASN322
|
4.2
|
17.1
|
1.0
|
|
CA
|
B:ASN322
|
4.2
|
18.8
|
1.0
|
|
HZ2
|
B:LYS353
|
4.2
|
33.1
|
1.0
|
|
CG
|
B:ASN322
|
4.3
|
21.5
|
1.0
|
|
HB3
|
B:LEU323
|
4.5
|
19.1
|
1.0
|
|
HD11
|
B:LEU323
|
4.6
|
19.5
|
1.0
|
|
OD1
|
B:ASN322
|
4.6
|
20.3
|
1.0
|
|
CD
|
B:LYS353
|
4.6
|
24.9
|
1.0
|
|
HZ1
|
B:LYS353
|
4.6
|
33.1
|
1.0
|
|
OE1
|
B:GLU350
|
4.6
|
39.3
|
1.0
|
|
OH
|
B:TYR144
|
4.6
|
28.9
|
1.0
|
|
HD2
|
B:LYS353
|
4.7
|
29.8
|
1.0
|
|
N
|
B:GLU324
|
4.7
|
17.5
|
1.0
|
|
HD1
|
B:TYR144
|
4.7
|
19.6
|
1.0
|
|
CZ
|
B:TYR144
|
4.7
|
22.8
|
1.0
|
|
HA
|
B:LEU323
|
4.8
|
18.8
|
1.0
|
|
CD1
|
B:TYR144
|
4.8
|
16.3
|
1.0
|
|
CE
|
B:LYS353
|
4.8
|
31.1
|
1.0
|
|
HD13
|
B:LEU323
|
4.9
|
19.5
|
1.0
|
|
C
|
B:LEU323
|
4.9
|
15.9
|
1.0
|
|
HE2
|
B:LYS353
|
5.0
|
37.3
|
1.0
|
|
Chlorine binding site 6 out
of 11 in 6dxy
Go back to
Chlorine Binding Sites List in 6dxy
Chlorine binding site 6 out
of 11 in the Murine N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa)
 Mono view
 Stereo pair view
|
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 6 of Murine N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:Cl201
b:46.6
occ:1.00
|
H
|
C:ASP61
|
2.2
|
37.8
|
1.0
|
|
HA
|
C:TYR60
|
2.9
|
34.4
|
1.0
|
|
N
|
C:ASP61
|
3.1
|
31.5
|
1.0
|
|
HD1
|
C:PHE64
|
3.1
|
36.7
|
1.0
|
|
HB3
|
C:ASP61
|
3.2
|
42.0
|
1.0
|
|
O
|
D:HOH671
|
3.2
|
54.2
|
1.0
|
|
HD1
|
C:TYR60
|
3.3
|
31.4
|
1.0
|
|
HB3
|
C:TYR60
|
3.6
|
32.4
|
1.0
|
|
CA
|
C:TYR60
|
3.6
|
28.6
|
1.0
|
|
HB2
|
C:ASP61
|
3.6
|
42.0
|
1.0
|
|
CD1
|
C:PHE64
|
3.7
|
30.6
|
1.0
|
|
CB
|
C:ASP61
|
3.7
|
35.0
|
1.0
|
|
O
|
C:HOH311
|
3.8
|
25.0
|
1.0
|
|
C
|
C:TYR60
|
3.8
|
30.2
|
1.0
|
|
HB3
|
C:PHE64
|
3.9
|
39.9
|
1.0
|
|
CA
|
C:ASP61
|
4.0
|
33.2
|
1.0
|
|
CB
|
C:TYR60
|
4.0
|
27.0
|
1.0
|
|
CD1
|
C:TYR60
|
4.0
|
26.2
|
1.0
|
|
HE1
|
C:PHE64
|
4.3
|
36.1
|
1.0
|
|
CE1
|
C:PHE64
|
4.3
|
30.1
|
1.0
|
|
CG
|
C:PHE64
|
4.4
|
32.4
|
1.0
|
|
CG
|
C:TYR60
|
4.4
|
25.8
|
1.0
|
|
CB
|
C:PHE64
|
4.5
|
33.3
|
1.0
|
|
O
|
C:HIS59
|
4.5
|
29.3
|
1.0
|
|
HB2
|
C:PHE64
|
4.5
|
39.9
|
1.0
|
|
HA
|
C:ASP61
|
4.7
|
39.9
|
1.0
|
|
O
|
C:ASP61
|
4.7
|
31.4
|
1.0
|
|
N
|
C:TYR60
|
4.8
|
28.4
|
1.0
|
|
C
|
C:ASP61
|
4.9
|
32.3
|
1.0
|
|
HB2
|
C:TYR60
|
4.9
|
32.4
|
1.0
|
|
Chlorine binding site 7 out
of 11 in 6dxy
Go back to
Chlorine Binding Sites List in 6dxy
Chlorine binding site 7 out
of 11 in the Murine N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa)
 Mono view
 Stereo pair view
|
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 7 of Murine N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:Cl402
b:15.0
occ:1.00
|
HG1
|
D:THR291
|
2.1
|
18.0
|
1.0
|
|
H
|
D:THR291
|
2.3
|
15.8
|
1.0
|
|
HE
|
D:ARG306
|
2.4
|
20.5
|
1.0
|
|
HH21
|
D:ARG306
|
2.5
|
21.2
|
1.0
|
|
OG1
|
D:THR291
|
2.9
|
15.0
|
1.0
|
|
H
|
D:TYR293
|
3.0
|
18.9
|
1.0
|
|
HB2
|
D:TYR293
|
3.2
|
21.2
|
1.0
|
|
N
|
D:THR291
|
3.2
|
13.2
|
1.0
|
|
O
|
D:HOH546
|
3.2
|
34.5
|
1.0
|
|
NE
|
D:ARG306
|
3.2
|
17.1
|
1.0
|
|
HB2
|
D:ARG306
|
3.3
|
19.8
|
1.0
|
|
NH2
|
D:ARG306
|
3.3
|
17.7
|
1.0
|
|
O
|
D:TYR293
|
3.4
|
15.6
|
1.0
|
|
HA
|
D:GLU290
|
3.5
|
15.3
|
1.0
|
|
HD2
|
D:TYR293
|
3.5
|
20.9
|
1.0
|
|
OE2
|
D:GLU290
|
3.5
|
13.8
|
1.0
|
|
HG23
|
D:THR291
|
3.6
|
17.0
|
1.0
|
|
H
|
D:ASN292
|
3.7
|
17.4
|
1.0
|
|
CZ
|
D:ARG306
|
3.7
|
17.9
|
1.0
|
|
N
|
D:TYR293
|
3.7
|
15.8
|
1.0
|
|
CB
|
D:THR291
|
3.8
|
14.2
|
1.0
|
|
CA
|
D:THR291
|
3.9
|
13.4
|
1.0
|
|
CB
|
D:TYR293
|
4.0
|
17.6
|
1.0
|
|
C
|
D:TYR293
|
4.0
|
16.6
|
1.0
|
|
HH22
|
D:ARG306
|
4.0
|
21.2
|
1.0
|
|
HG3
|
D:ARG306
|
4.1
|
19.9
|
1.0
|
|
N
|
D:ASN292
|
4.1
|
14.5
|
1.0
|
|
CA
|
D:TYR293
|
4.1
|
16.8
|
1.0
|
|
CG2
|
D:THR291
|
4.1
|
14.2
|
1.0
|
|
CB
|
D:ARG306
|
4.1
|
16.5
|
1.0
|
|
C
|
D:GLU290
|
4.2
|
12.6
|
1.0
|
|
CD
|
D:GLU290
|
4.2
|
13.4
|
1.0
|
|
C
|
D:THR291
|
4.3
|
13.6
|
1.0
|
|
CA
|
D:GLU290
|
4.3
|
12.7
|
1.0
|
|
CD2
|
D:TYR293
|
4.3
|
17.4
|
1.0
|
|
HB2
|
D:ALA299
|
4.3
|
26.4
|
1.0
|
|
HA
|
D:HIS295
|
4.3
|
20.8
|
1.0
|
|
CD
|
D:ARG306
|
4.4
|
17.4
|
1.0
|
|
CG
|
D:ARG306
|
4.4
|
16.6
|
1.0
|
|
HG21
|
D:THR291
|
4.5
|
17.0
|
1.0
|
|
HB3
|
D:ARG306
|
4.5
|
19.8
|
1.0
|
|
OE1
|
D:GLU290
|
4.6
|
13.8
|
1.0
|
|
CG
|
D:TYR293
|
4.7
|
18.0
|
1.0
|
|
HB
|
D:THR291
|
4.7
|
17.1
|
1.0
|
|
HB3
|
D:TYR293
|
4.7
|
21.2
|
1.0
|
|
O
|
D:HOH533
|
4.8
|
17.3
|
1.0
|
|
HA
|
D:THR291
|
4.8
|
16.1
|
1.0
|
|
HG12
|
D:VAL289
|
4.8
|
16.7
|
1.0
|
|
C
|
D:ASN292
|
4.9
|
15.8
|
1.0
|
|
O
|
D:VAL289
|
4.9
|
13.9
|
1.0
|
|
HD3
|
D:ARG306
|
4.9
|
20.9
|
1.0
|
|
HG22
|
D:THR291
|
5.0
|
17.0
|
1.0
|
|
HD2
|
D:ARG306
|
5.0
|
20.9
|
1.0
|
|
Chlorine binding site 8 out
of 11 in 6dxy
Go back to
Chlorine Binding Sites List in 6dxy
Chlorine binding site 8 out
of 11 in the Murine N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa)
 Mono view
 Stereo pair view
|
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 8 of Murine N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:Cl403
b:34.5
occ:1.00
|
HE
|
D:ARG226
|
2.4
|
28.2
|
1.0
|
|
HH21
|
D:ARG226
|
2.6
|
31.9
|
1.0
|
|
HZ2
|
D:LYS227
|
2.7
|
46.2
|
1.0
|
|
HG
|
D:SER230
|
2.9
|
31.4
|
1.0
|
|
NE
|
D:ARG226
|
3.2
|
23.5
|
1.0
|
|
HB2
|
D:SER230
|
3.2
|
29.2
|
1.0
|
|
NH2
|
D:ARG226
|
3.3
|
26.6
|
1.0
|
|
HD13
|
C:LEU45
|
3.3
|
37.2
|
1.0
|
|
HD11
|
C:LEU45
|
3.3
|
37.2
|
1.0
|
|
HZ
|
D:PHE174
|
3.4
|
26.0
|
1.0
|
|
HD2
|
D:LYS227
|
3.4
|
42.2
|
1.0
|
|
HD21
|
C:LEU45
|
3.4
|
35.5
|
1.0
|
|
HD22
|
C:LEU45
|
3.4
|
35.5
|
1.0
|
|
HG2
|
D:ARG226
|
3.5
|
25.0
|
1.0
|
|
NZ
|
D:LYS227
|
3.5
|
38.5
|
1.0
|
|
OG
|
D:SER230
|
3.5
|
26.2
|
1.0
|
|
HZ3
|
D:LYS227
|
3.7
|
46.2
|
1.0
|
|
CZ
|
D:ARG226
|
3.7
|
24.9
|
1.0
|
|
CB
|
D:SER230
|
3.7
|
24.3
|
1.0
|
|
CD1
|
C:LEU45
|
3.8
|
31.0
|
1.0
|
|
HB3
|
D:SER230
|
3.9
|
29.2
|
1.0
|
|
CD2
|
C:LEU45
|
3.9
|
29.6
|
1.0
|
|
O
|
D:HOH514
|
3.9
|
60.0
|
1.0
|
|
HZ1
|
D:LYS227
|
4.0
|
46.2
|
1.0
|
|
HH22
|
D:ARG226
|
4.1
|
31.9
|
1.0
|
|
CD
|
D:LYS227
|
4.1
|
35.2
|
1.0
|
|
CZ
|
D:PHE174
|
4.2
|
21.7
|
1.0
|
|
HE2
|
D:PHE174
|
4.2
|
27.1
|
1.0
|
|
HD3
|
D:LYS227
|
4.2
|
42.2
|
1.0
|
|
CG
|
D:ARG226
|
4.2
|
20.8
|
1.0
|
|
CE
|
D:LYS227
|
4.3
|
32.4
|
1.0
|
|
HA
|
D:LYS227
|
4.3
|
28.0
|
1.0
|
|
CD
|
D:ARG226
|
4.3
|
21.8
|
1.0
|
|
HE3
|
D:LYS227
|
4.4
|
38.9
|
1.0
|
|
CG
|
C:LEU45
|
4.5
|
30.2
|
1.0
|
|
HG3
|
D:ARG226
|
4.5
|
25.0
|
1.0
|
|
HD12
|
C:LEU45
|
4.6
|
37.2
|
1.0
|
|
CE2
|
D:PHE174
|
4.6
|
22.6
|
1.0
|
|
HD23
|
C:LEU45
|
4.7
|
35.5
|
1.0
|
|
HD3
|
D:ARG226
|
4.8
|
26.2
|
1.0
|
|
O
|
D:ARG226
|
4.8
|
20.6
|
1.0
|
|
HD2
|
D:ARG226
|
4.9
|
26.2
|
1.0
|
|
Chlorine binding site 9 out
of 11 in 6dxy
Go back to
Chlorine Binding Sites List in 6dxy
Chlorine binding site 9 out
of 11 in the Murine N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa)
 Mono view
 Stereo pair view
|
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 9 of Murine N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:Cl404
b:50.4
occ:1.00
|
H
|
D:ASP294
|
2.1
|
21.1
|
1.0
|
|
O
|
D:HOH643
|
2.7
|
54.9
|
1.0
|
|
HB3
|
D:TYR293
|
2.9
|
21.2
|
1.0
|
|
N
|
D:ASP294
|
3.0
|
17.6
|
1.0
|
|
HZ1
|
D:LYS203
|
3.0
|
53.4
|
1.0
|
|
HA
|
D:TYR293
|
3.0
|
20.2
|
1.0
|
|
HZ3
|
D:LYS203
|
3.1
|
53.4
|
1.0
|
|
HB2
|
D:ASP294
|
3.2
|
23.0
|
1.0
|
|
HD1
|
D:TYR293
|
3.3
|
23.0
|
1.0
|
|
HD2
|
D:LYS297
|
3.4
|
34.4
|
1.0
|
|
NZ
|
D:LYS203
|
3.5
|
44.5
|
1.0
|
|
O
|
D:HOH616
|
3.5
|
34.2
|
1.0
|
|
CA
|
D:TYR293
|
3.6
|
16.8
|
1.0
|
|
CB
|
D:TYR293
|
3.6
|
17.6
|
1.0
|
|
O
|
D:HOH646
|
3.6
|
56.8
|
1.0
|
|
CB
|
D:ASP294
|
3.8
|
19.1
|
1.0
|
|
CG
|
D:ASP294
|
3.8
|
19.3
|
1.0
|
|
C
|
D:TYR293
|
3.8
|
16.6
|
1.0
|
|
HZ2
|
D:LYS203
|
3.8
|
53.4
|
1.0
|
|
CA
|
D:ASP294
|
4.0
|
17.7
|
1.0
|
|
OD2
|
D:ASP294
|
4.0
|
20.6
|
1.0
|
|
HB2
|
D:LYS297
|
4.0
|
27.6
|
1.0
|
|
HD3
|
D:LYS297
|
4.0
|
34.4
|
1.0
|
|
CD1
|
D:TYR293
|
4.1
|
19.1
|
1.0
|
|
HH
|
D:TYR252
|
4.1
|
19.8
|
1.0
|
|
CD
|
D:LYS297
|
4.1
|
28.7
|
1.0
|
|
OD1
|
D:ASP294
|
4.2
|
18.2
|
1.0
|
|
HZ3
|
D:LYS297
|
4.3
|
39.2
|
1.0
|
|
CG
|
D:TYR293
|
4.4
|
18.0
|
1.0
|
|
HB2
|
D:TYR293
|
4.4
|
21.2
|
1.0
|
|
HZ2
|
D:LYS297
|
4.4
|
39.2
|
1.0
|
|
OH
|
D:TYR252
|
4.5
|
16.5
|
1.0
|
|
O
|
D:ASP294
|
4.6
|
18.7
|
1.0
|
|
HE2
|
D:LYS203
|
4.6
|
50.3
|
1.0
|
|
HA
|
D:ASP294
|
4.7
|
21.3
|
1.0
|
|
HB3
|
D:ASP294
|
4.7
|
23.0
|
1.0
|
|
CE
|
D:LYS203
|
4.7
|
42.0
|
1.0
|
|
NZ
|
D:LYS297
|
4.7
|
32.7
|
1.0
|
|
CB
|
D:LYS297
|
4.8
|
23.0
|
1.0
|
|
C
|
D:ASP294
|
4.8
|
17.8
|
1.0
|
|
HB3
|
D:LYS297
|
4.9
|
27.6
|
1.0
|
|
N
|
D:TYR293
|
5.0
|
15.8
|
1.0
|
|
O
|
D:TYR293
|
5.0
|
15.6
|
1.0
|
|
Chlorine binding site 10 out
of 11 in 6dxy
Go back to
Chlorine Binding Sites List in 6dxy
Chlorine binding site 10 out
of 11 in the Murine N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa)
 Mono view
 Stereo pair view
|
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 10 of Murine N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:Cl405
b:54.1
occ:1.00
|
H
|
D:LEU323
|
2.4
|
25.4
|
1.0
|
|
HB2
|
D:ASN322
|
2.7
|
30.2
|
1.0
|
|
HB2
|
D:LEU323
|
2.9
|
24.1
|
1.0
|
|
HG
|
D:LEU323
|
2.9
|
24.2
|
1.0
|
|
HE1
|
D:TYR144
|
3.0
|
26.7
|
1.0
|
|
HD12
|
D:LEU323
|
3.2
|
25.2
|
1.0
|
|
N
|
D:LEU323
|
3.3
|
21.1
|
1.0
|
|
CB
|
D:LEU323
|
3.5
|
20.1
|
1.0
|
|
CG
|
D:LEU323
|
3.5
|
20.1
|
1.0
|
|
CB
|
D:ASN322
|
3.7
|
25.2
|
1.0
|
|
CE1
|
D:TYR144
|
3.8
|
22.3
|
1.0
|
|
CD1
|
D:LEU323
|
3.8
|
21.0
|
1.0
|
|
CA
|
D:LEU323
|
4.0
|
19.6
|
1.0
|
|
OE1
|
D:GLU350
|
4.1
|
34.0
|
1.0
|
|
HA
|
D:ASN322
|
4.1
|
27.6
|
1.0
|
|
HB3
|
D:ASN322
|
4.1
|
30.2
|
1.0
|
|
C
|
D:ASN322
|
4.2
|
21.1
|
1.0
|
|
CA
|
D:ASN322
|
4.3
|
23.0
|
1.0
|
|
HD11
|
D:LEU323
|
4.3
|
25.2
|
1.0
|
|
H
|
D:GLU324
|
4.3
|
25.1
|
1.0
|
|
HD1
|
D:TYR144
|
4.4
|
20.6
|
1.0
|
|
HB3
|
D:LEU323
|
4.4
|
24.1
|
1.0
|
|
CG
|
D:ASN322
|
4.5
|
25.4
|
1.0
|
|
CD1
|
D:TYR144
|
4.5
|
17.2
|
1.0
|
|
HG3
|
D:LYS353
|
4.6
|
31.3
|
1.0
|
|
HD13
|
D:LEU323
|
4.6
|
25.2
|
1.0
|
|
HA
|
D:LEU323
|
4.7
|
23.5
|
1.0
|
|
CZ
|
D:TYR144
|
4.7
|
19.8
|
1.0
|
|
OH
|
D:TYR144
|
4.7
|
24.3
|
1.0
|
|
HE3
|
D:LYS353
|
4.8
|
50.0
|
1.0
|
|
OD1
|
D:ASN322
|
4.9
|
23.9
|
1.0
|
|
N
|
D:GLU324
|
4.9
|
20.9
|
1.0
|
|
H61
|
D:PG4407
|
4.9
|
79.5
|
1.0
|
|
CD2
|
D:LEU323
|
4.9
|
18.4
|
1.0
|
|
C
|
D:LEU323
|
5.0
|
19.4
|
1.0
|
|
Reference:
A.Gorelik,
A.Gebai,
K.Illes,
D.Piomelli,
B.Nagar.
Molecular Mechanism of Activation of the Immunoregulatory Amidase Naaa. Proc. Natl. Acad. Sci. V. 115 10032 2018U.S.A..
ISSN: ESSN 1091-6490
PubMed: 30301806
DOI: 10.1073/PNAS.1811759115
Page generated: Sat Dec 12 12:54:07 2020
|
