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Chlorine in PDB 6dz0: Crystal Structure of Human 5'-Deoxy-5'-Methylthioadenosine Phosphorylase in Complex with (3R,4S)-1-((4-Amino-5H-Pyrrolo[3,2- D]Pyrimidin-7-Yl)Methyl)-4-((Pent-4-Yn-1-Ylthio)Methyl)Pyrrolidin-3- Ol
Enzymatic activity of Crystal Structure of Human 5'-Deoxy-5'-Methylthioadenosine Phosphorylase in Complex with (3R,4S)-1-((4-Amino-5H-Pyrrolo[3,2- D]Pyrimidin-7-Yl)Methyl)-4-((Pent-4-Yn-1-Ylthio)Methyl)Pyrrolidin-3- Ol
All present enzymatic activity of Crystal Structure of Human 5'-Deoxy-5'-Methylthioadenosine Phosphorylase in Complex with (3R,4S)-1-((4-Amino-5H-Pyrrolo[3,2- D]Pyrimidin-7-Yl)Methyl)-4-((Pent-4-Yn-1-Ylthio)Methyl)Pyrrolidin-3- Ol:
2.4.2.28;
2.4.2.28;
Protein crystallography data
The structure of Crystal Structure of Human 5'-Deoxy-5'-Methylthioadenosine Phosphorylase in Complex with (3R,4S)-1-((4-Amino-5H-Pyrrolo[3,2- D]Pyrimidin-7-Yl)Methyl)-4-((Pent-4-Yn-1-Ylthio)Methyl)Pyrrolidin-3- Ol, PDB code: 6dz0
was solved by
R.K.Harijan,
R.G.Ducati,
J.B.Bonanno,
S.C.Almo,
V.L.Schramm,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 105.49 / 1.62 |
| Space group | P 3 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 121.812, 121.812, 44.372, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 15.5 / 17.6 |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Human 5'-Deoxy-5'-Methylthioadenosine Phosphorylase in Complex with (3R,4S)-1-((4-Amino-5H-Pyrrolo[3,2- D]Pyrimidin-7-Yl)Methyl)-4-((Pent-4-Yn-1-Ylthio)Methyl)Pyrrolidin-3- Ol
(pdb code 6dz0). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Human 5'-Deoxy-5'-Methylthioadenosine Phosphorylase in Complex with (3R,4S)-1-((4-Amino-5H-Pyrrolo[3,2- D]Pyrimidin-7-Yl)Methyl)-4-((Pent-4-Yn-1-Ylthio)Methyl)Pyrrolidin-3- Ol, PDB code: 6dz0:
In total only one binding site of Chlorine was determined in the Crystal Structure of Human 5'-Deoxy-5'-Methylthioadenosine Phosphorylase in Complex with (3R,4S)-1-((4-Amino-5H-Pyrrolo[3,2- D]Pyrimidin-7-Yl)Methyl)-4-((Pent-4-Yn-1-Ylthio)Methyl)Pyrrolidin-3- Ol, PDB code: 6dz0:
Chlorine binding site 1 out of 1 in 6dz0
Go back to
Chlorine Binding Sites List in 6dz0
Chlorine binding site 1 out
of 1 in the Crystal Structure of Human 5'-Deoxy-5'-Methylthioadenosine Phosphorylase in Complex with (3R,4S)-1-((4-Amino-5H-Pyrrolo[3,2- D]Pyrimidin-7-Yl)Methyl)-4-((Pent-4-Yn-1-Ylthio)Methyl)Pyrrolidin-3- Ol
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Crystal Structure of Human 5'-Deoxy-5'-Methylthioadenosine Phosphorylase in Complex with (3R,4S)-1-((4-Amino-5H-Pyrrolo[3,2- D]Pyrimidin-7-Yl)Methyl)-4-((Pent-4-Yn-1-Ylthio)Methyl)Pyrrolidin-3- Ol within 5.0Å range:
|
Reference:
R.K.Harijan,
O.Hoff,
R.G.Ducati,
R.S.Firestone,
B.M.Hirsch,
G.B.Evans,
V.L.Schramm,
P.C.Tyler.
Selective Inhibitors of Helicobacter Pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase. J. Med. Chem. V. 62 3286 2019.
ISSN: ISSN 1520-4804
PubMed: 30860833
DOI: 10.1021/ACS.JMEDCHEM.8B01642
Page generated: Sat Jul 27 21:59:18 2024
ISSN: ISSN 1520-4804
PubMed: 30860833
DOI: 10.1021/ACS.JMEDCHEM.8B01642
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