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Atomistry » Chlorine » PDB 6dy1-6e74 » 6dz3 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 6dy1-6e74 » 6dz3 » |
Chlorine in PDB 6dz3: Crystal Structure of Human 5'-Deoxy-5'-Methylthioadenosine Phosphorylase in Complex with (3R,4S)-1-((4-Amino-5H-Pyrrolo[3,2- D]Pyrimidin-7-Yl)Methyl)-4-(((3-(1-Butyl-1H-1,2,3-Triazol-4-Yl) Propyl)Thio)Methyl)Pyrrolidin-3-OlEnzymatic activity of Crystal Structure of Human 5'-Deoxy-5'-Methylthioadenosine Phosphorylase in Complex with (3R,4S)-1-((4-Amino-5H-Pyrrolo[3,2- D]Pyrimidin-7-Yl)Methyl)-4-(((3-(1-Butyl-1H-1,2,3-Triazol-4-Yl) Propyl)Thio)Methyl)Pyrrolidin-3-Ol
All present enzymatic activity of Crystal Structure of Human 5'-Deoxy-5'-Methylthioadenosine Phosphorylase in Complex with (3R,4S)-1-((4-Amino-5H-Pyrrolo[3,2- D]Pyrimidin-7-Yl)Methyl)-4-(((3-(1-Butyl-1H-1,2,3-Triazol-4-Yl) Propyl)Thio)Methyl)Pyrrolidin-3-Ol:
2.4.2.28; Protein crystallography data
The structure of Crystal Structure of Human 5'-Deoxy-5'-Methylthioadenosine Phosphorylase in Complex with (3R,4S)-1-((4-Amino-5H-Pyrrolo[3,2- D]Pyrimidin-7-Yl)Methyl)-4-(((3-(1-Butyl-1H-1,2,3-Triazol-4-Yl) Propyl)Thio)Methyl)Pyrrolidin-3-Ol, PDB code: 6dz3
was solved by
R.K.Harijan,
R.G.Ducati,
J.B.Bonanno,
S.C.Almo,
V.L.Schramm,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Human 5'-Deoxy-5'-Methylthioadenosine Phosphorylase in Complex with (3R,4S)-1-((4-Amino-5H-Pyrrolo[3,2- D]Pyrimidin-7-Yl)Methyl)-4-(((3-(1-Butyl-1H-1,2,3-Triazol-4-Yl) Propyl)Thio)Methyl)Pyrrolidin-3-Ol
(pdb code 6dz3). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 5 binding sites of Chlorine where determined in the Crystal Structure of Human 5'-Deoxy-5'-Methylthioadenosine Phosphorylase in Complex with (3R,4S)-1-((4-Amino-5H-Pyrrolo[3,2- D]Pyrimidin-7-Yl)Methyl)-4-(((3-(1-Butyl-1H-1,2,3-Triazol-4-Yl) Propyl)Thio)Methyl)Pyrrolidin-3-Ol, PDB code: 6dz3: Jump to Chlorine binding site number: 1; 2; 3; 4; 5; Chlorine binding site 1 out of 5 in 6dz3Go back to Chlorine Binding Sites List in 6dz3
Chlorine binding site 1 out
of 5 in the Crystal Structure of Human 5'-Deoxy-5'-Methylthioadenosine Phosphorylase in Complex with (3R,4S)-1-((4-Amino-5H-Pyrrolo[3,2- D]Pyrimidin-7-Yl)Methyl)-4-(((3-(1-Butyl-1H-1,2,3-Triazol-4-Yl) Propyl)Thio)Methyl)Pyrrolidin-3-Ol
Mono view Stereo pair view
Chlorine binding site 2 out of 5 in 6dz3Go back to Chlorine Binding Sites List in 6dz3
Chlorine binding site 2 out
of 5 in the Crystal Structure of Human 5'-Deoxy-5'-Methylthioadenosine Phosphorylase in Complex with (3R,4S)-1-((4-Amino-5H-Pyrrolo[3,2- D]Pyrimidin-7-Yl)Methyl)-4-(((3-(1-Butyl-1H-1,2,3-Triazol-4-Yl) Propyl)Thio)Methyl)Pyrrolidin-3-Ol
Mono view Stereo pair view
Chlorine binding site 3 out of 5 in 6dz3Go back to Chlorine Binding Sites List in 6dz3
Chlorine binding site 3 out
of 5 in the Crystal Structure of Human 5'-Deoxy-5'-Methylthioadenosine Phosphorylase in Complex with (3R,4S)-1-((4-Amino-5H-Pyrrolo[3,2- D]Pyrimidin-7-Yl)Methyl)-4-(((3-(1-Butyl-1H-1,2,3-Triazol-4-Yl) Propyl)Thio)Methyl)Pyrrolidin-3-Ol
Mono view Stereo pair view
Chlorine binding site 4 out of 5 in 6dz3Go back to Chlorine Binding Sites List in 6dz3
Chlorine binding site 4 out
of 5 in the Crystal Structure of Human 5'-Deoxy-5'-Methylthioadenosine Phosphorylase in Complex with (3R,4S)-1-((4-Amino-5H-Pyrrolo[3,2- D]Pyrimidin-7-Yl)Methyl)-4-(((3-(1-Butyl-1H-1,2,3-Triazol-4-Yl) Propyl)Thio)Methyl)Pyrrolidin-3-Ol
Mono view Stereo pair view
Chlorine binding site 5 out of 5 in 6dz3Go back to Chlorine Binding Sites List in 6dz3
Chlorine binding site 5 out
of 5 in the Crystal Structure of Human 5'-Deoxy-5'-Methylthioadenosine Phosphorylase in Complex with (3R,4S)-1-((4-Amino-5H-Pyrrolo[3,2- D]Pyrimidin-7-Yl)Methyl)-4-(((3-(1-Butyl-1H-1,2,3-Triazol-4-Yl) Propyl)Thio)Methyl)Pyrrolidin-3-Ol
Mono view Stereo pair view
Reference:
R.K.Harijan,
O.Hoff,
R.G.Ducati,
R.S.Firestone,
B.M.Hirsch,
G.B.Evans,
V.L.Schramm,
P.C.Tyler.
Selective Inhibitors of Helicobacter Pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase. J. Med. Chem. V. 62 3286 2019.
Page generated: Sat Jul 27 21:59:19 2024
ISSN: ISSN 1520-4804 PubMed: 30860833 DOI: 10.1021/ACS.JMEDCHEM.8B01642 |
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