Chlorine in PDB 6dzn: Pan-Ebolavirus Human Antibody Adi-15878 Fab

The structure of Pan-Ebolavirus Human Antibody Adi-15878 Fab, PDB code: 6dzn was solved by C.D.Murin, A.B.Ward, J.F.Bruhn, R.Stanfield, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	46.45 / 2.10
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	42.057, 96.837, 54.309, 90.00, 102.91, 90.00
R / Rfree (%)	22.4 / 26.5

The binding sites of Chlorine atom in the Pan-Ebolavirus Human Antibody Adi-15878 Fab (pdb code 6dzn). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 6 binding sites of Chlorine where determined in the Pan-Ebolavirus Human Antibody Adi-15878 Fab, PDB code: 6dzn:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6;

Chlorine binding site 1 out of 6 in the Pan-Ebolavirus Human Antibody Adi-15878 Fab


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Pan-Ebolavirus Human Antibody Adi-15878 Fab within 5.0Å range: probe atom residue distance (Å) B Occ L:Cl301 b:47.5 occ:1.00 N L:SER9 3.3 31.6 1.0 O L:HOH488 3.4 35.5 1.0 CB L:PRO8 3.9 31.7 1.0 CA L:PRO8 3.9 31.0 1.0 CB L:SER9 4.0 31.9 1.0 C L:PRO8 4.1 30.6 1.0 CA L:SER9 4.2 31.0 1.0 N L:THR10 4.3 32.0 1.0 OG L:SER9 4.4 33.2 1.0 O L:THR10 4.7 30.5 1.0 C L:SER9 4.8 30.4 1.0 CG2 L:THR10 4.9 34.0 1.0

Chlorine binding site 2 out of 6 in the Pan-Ebolavirus Human Antibody Adi-15878 Fab


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Pan-Ebolavirus Human Antibody Adi-15878 Fab within 5.0Å range: probe atom residue distance (Å) B Occ L:Cl302 b:45.1 occ:1.00 NH1 L:ARG61 3.2 31.8 1.0 CB L:ARG61 3.6 29.9 1.0 OG L:SER60 3.6 31.1 1.0 N L:ARG61 3.6 29.5 1.0 CB L:PRO59 3.8 29.9 1.0 CD L:ARG61 3.8 31.1 1.0 N L:SER60 4.1 30.2 1.0 CA L:ARG61 4.1 30.4 1.0 CG L:ARG61 4.1 29.9 1.0 CZ L:ARG61 4.3 31.7 1.0 NE L:ARG61 4.5 30.4 1.0 CA L:PRO59 4.5 30.7 1.0 C L:PRO59 4.5 29.5 1.0 C L:SER60 4.6 28.1 1.0 CA L:SER60 4.7 29.8 1.0 CB L:SER60 4.7 29.7 1.0 O L:HOH473 4.8 34.0 1.0 CG L:PRO59 5.0 30.5 1.0

Chlorine binding site 3 out of 6 in the Pan-Ebolavirus Human Antibody Adi-15878 Fab


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Pan-Ebolavirus Human Antibody Adi-15878 Fab within 5.0Å range: probe atom residue distance (Å) B Occ L:Cl303 b:47.1 occ:1.00 O L:HOH492 3.6 29.3 1.0 O H:HOH418 3.7 31.8 1.0 OE1 L:GLN38 3.8 27.1 1.0 NE2 H:GLN39 3.8 27.8 1.0 CD L:GLN38 4.0 27.1 1.0 OE1 H:GLN39 4.0 27.0 1.0 O H:HOH422 4.0 28.6 1.0 O L:HOH412 4.0 28.2 1.0 NE2 L:GLN38 4.1 27.4 1.0 CD H:GLN39 4.1 27.9 1.0 CA L:PRO40 4.2 30.6 1.0 O H:HOH479 4.2 31.4 1.0 O L:LYS39 4.3 29.7 1.0 N L:GLY41 4.4 31.0 1.0 CG L:GLN38 4.6 27.6 1.0 O L:GLU42 4.8 30.9 1.0 C L:PRO40 4.8 31.7 1.0 N L:PRO40 4.8 30.5 1.0 C L:LYS39 4.8 30.9 1.0 CB L:PRO40 5.0 32.6 1.0

Chlorine binding site 4 out of 6 in the Pan-Ebolavirus Human Antibody Adi-15878 Fab


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Pan-Ebolavirus Human Antibody Adi-15878 Fab within 5.0Å range: probe atom residue distance (Å) B Occ H:Cl301 b:33.0 occ:1.00 O H:HOH424 3.2 29.7 1.0 CA H:GLY55 3.5 31.5 1.0 N H:GLY55 3.8 29.7 1.0 CD1 H:LEU53 4.2 26.9 1.0 CB H:LEU53 4.2 27.7 1.0 O H:HOH468 4.4 32.2 1.0 O H:HOH426 4.5 30.2 1.0 C H:GLY55 4.5 31.4 1.0 CG H:LEU53 4.8 27.5 1.0

Chlorine binding site 5 out of 6 in the Pan-Ebolavirus Human Antibody Adi-15878 Fab


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Pan-Ebolavirus Human Antibody Adi-15878 Fab within 5.0Å range: probe atom residue distance (Å) B Occ H:Cl302 b:27.8 occ:1.00 O H:HOH424 3.0 29.7 1.0 O H:HOH447 3.3 28.6 1.0 N H:LEU53 3.5 27.8 1.0 N H:GLY52A 3.7 27.9 1.0 CG H:LEU53 3.8 27.5 1.0 CB H:SER52 4.0 28.2 1.0 CA H:GLY52A 4.0 28.1 1.0 CB H:LEU53 4.1 27.7 1.0 C H:GLY52A 4.2 28.0 1.0 OG H:SER52 4.3 29.1 1.0 CA H:LEU53 4.4 29.3 1.0 CD1 H:LEU53 4.4 26.9 1.0 C H:SER52 4.5 28.1 1.0 O H:HOH426 4.8 30.2 1.0 CA H:SER52 4.8 28.7 1.0 CD2 H:LEU53 4.9 26.8 1.0

Chlorine binding site 6 out of 6 in the Pan-Ebolavirus Human Antibody Adi-15878 Fab


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Pan-Ebolavirus Human Antibody Adi-15878 Fab within 5.0Å range: probe atom residue distance (Å) B Occ H:Cl303 b:31.3 occ:1.00 O L:HOH520 2.8 30.4 1.0 O H:HOH417 2.8 28.3 1.0 N H:TRP47 3.3 24.6 1.0 N L:PHE98 3.5 26.4 1.0 CA L:ILE97 3.8 26.6 1.0 CA H:GLU46 3.8 23.5 1.0 CD1 L:ILE97 3.9 34.9 1.0 C H:GLU46 4.0 24.7 1.0 CG H:GLU46 4.0 26.5 1.0 CG2 L:ILE97 4.1 28.6 1.0 C L:ILE97 4.2 26.2 1.0 CB H:TRP47 4.2 25.9 1.0 CA H:TRP47 4.3 25.1 1.0 CD2 L:PHE98 4.3 23.3 1.0 O H:LEU45 4.3 25.7 1.0 CB L:ILE97 4.3 28.1 1.0 O H:HOH425 4.4 29.4 1.0 O H:TRP47 4.4 26.0 1.0 O L:PRO96 4.4 28.7 1.0 CB H:GLU46 4.5 25.8 1.0 CB L:PHE98 4.5 23.1 1.0 CA L:PHE98 4.5 25.3 1.0 O L:PHE98 4.6 24.7 1.0 CG1 L:ILE97 4.7 31.0 1.0 N H:GLU46 4.8 24.6 1.0 N L:ILE97 4.8 26.8 1.0 C H:TRP47 4.9 25.7 1.0 O L:HOH517 4.9 29.4 1.0 CG L:PHE98 4.9 23.5 1.0 C H:LEU45 5.0 24.6 1.0

C.D.Murin, J.F.Bruhn, Z.A.Bornholdt, J.Copps, R.Stanfield, A.B.Ward. Structural Basis of Pan-Ebolavirus Neutralization By An Antibody Targeting the Glycoprotein Fusion Loop. Cell Rep V. 24 2723 2018.
ISSN: ESSN 2211-1247
PubMed: 30184505
DOI: 10.1016/J.CELREP.2018.08.009